Plasma Adiponectin Levels in Acute Liver Failure Patients Treated with Plasma Filtration with Dialysis and Plasma Exchange

Abstract

Plasma filtration with dialysis (PDF) is a blood purification therapy in which simple plasma exchange (PE) is performed using a selective membrane plasma separator while the dialysate flows outside of the hollow fibers. Improvement of hypoadiponectinemia is considered to be a useful therapeutic approach for ameliorating fatal conditions including cardio-metabolic and infectious disease. We investigated the effects of PDF in comparison to PE in terms of plasma adiponectin (APN) changes in patients with acute liver failure. Seventeen patients with liver failure were studied; PDF was performed 55 times and PE 14 times. Plasma APN levels increased significantly after PDF, while decreasing significantly after PE. PDF appears to be among the most useful blood purification therapies in acute liver failure cases in terms of increasing APN levels.

Plasma filtration with dialysis for the treatment of capillary leak syndrome occurring secondary to surgery for colon cancer‐related perforating peritonitis

“…In addition, previous reports have shown that PDF increases adiponectin levels in patients with liver failure; thus, it may be useful as a treatment for patients with liver failure. 12 In this case, PDF showed a remarkable effect, due to which we can surmise that substances within the treatment target of PDF may be the cause of CLS. PDF may ameliorate capillary leaks.…”

“…Reducing the use of FFP can lower the cost of treatment and reduce the risk of blood transfusion complications. In addition, previous reports have shown that PDF increases adiponectin levels in patients with liver failure; thus, it may be useful as a treatment for patients with liver failure 12 …”

Selective Plasma Exchange for Critically Ill Patients Accompanied With Thrombocytopenia

“…Plasma filtration with dialysis (PDF) is a blood purification therapy in which sPE is performed while the dialysate flows outside of the hollow fibers. We have previously reported that plasma adiponectin levels increased significantly after PDF, but decreased after conventional PE . Adiponectin exerts potent anti‐inflammatory effects, as documented by a reduction in inflammatory mediators .…”

Continuous Plasma Exchange With Dialysis for Severe Sepsis: Case Series of a Novel Blood Purification Method

“…cPED is a new blood purification method that simplifies plasma diafiltration (PDF), which utilizes a selective membrane plasma separator to perform PE while the dialysate is pumped outside the hollow fiber [8]. PDF has already been used for acute liver failure [11][12][13]. Continuous PDF, in which PDF is performed at a slower place in hemodynamically unstable patients, is used clinically [14].…”