Plasma adropin level in patients with pseudoexfoliation

Abstract

The aim of this study was to evaluate plasma adropin levels in patients with pseudoexfoliation (PEX). This retrospective case-control study included 35 patients with PEX and 35 individuals without PEX who served as controls. Plasma adropin levels with triglycerides, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and haemoglobin A1c (HGBA1C) concentrations were measured in both groups. The mean serum adropin levels were 3.24 ± 0.95 ng/mL (range, 1.90-7.88 ng/mL) in patients with PEX syndrome and 5.78 ± 2.85 ng/mL (range, 2.08-5.41 ng/mL) in PEX glaucoma patients. There was no statistically significant difference in mean adropin levels between PEX syndrome and PEX glaucoma patients. However, similar adropin levels were found in the PEX glaucoma patients and the control group (P > 0.05). The mean serum adropin levels were 3.34 ± 0.89 ng/mL (range, 1.90-5.39 ng/mL) in the PEX group and 5.78 ± 2.85 ng/mL (range, 3.08-11.06 ng/mL) in the control group. The mean serum adropin level of the PEX group was significantly lower than that of the control group (P < 0.001). There were no significant differences between the two groups in terms of serum glucose, total cholesterol, LDL, HDL, HGBA1C, triglycerides levels, or body mass index (all P > 0.05). Adropin level is lower in patients with PEX.

Genetics, Diagnosis, and Monitoring of Pseudoexfoliation Glaucoma

“…The authors posited that these ratios may eventually be useful in predicting the progression to glaucoma in pseudoexfoliation patients, but a favorable sensitivity and specificity profile of such screening compared to current ophthalmic examination methods are yet to be demonstrated. It has also been recently reported that pseudoexfoliation patients have lower serum levels of adropin, a metabolic regulator that modulates glucose-mediated insulin release (30, 31). The implications and reproducibility of this association are unclear.…”

Potential Roles of Adropin in Central Nervous System: Review of Current Literature

“…Plasma adropin level has a positive association with severity of heart failure and negative correlation with left ventricular ejection fraction (Lian et al, 2011 ). Low level of plasma adropin is predictive of pseudoexfoliation (Oğurel et al, 2016 ), coronary slow flow phenomenon (Demircelik and Kurtul, 2015 ), saphenous vein graft occlusion following coronary artery bypass grafting (Demircelik, 2014 ), as well as pediatric obstructive sleep apnea in the presence of endothelial dysfunction (Gozal et al, 2013 ). While Gu et al ( 2015 ) described plasma adropin level as an independent indicator of hypertension, other studies failed to show this association (Altincik and Sayin, 2015 ).…”