Plasma apolipoprotein E and severity of suicidal behaviour

Asellus, Peter; Nordström, Anna-Lena; Jokinen, Jussi

doi:10.1016/j.jad.2015.09.024

Cited by 13 publications

(11 citation statements)

References 162 publications

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“…Few studies have assessed a direct connection between apoE protein levels and AD status, although plasma apoE-related disease-specific phenotypic traits have been investigated in various diseases such as Down syndrome [ 51 ], lung [ 52 ] and liver diseases [ 53 ], and in relation to suicide [ 54 ]. Importantly, the APOE ε4 genotype also increases the risk of dementia with Lewy bodies (DLB) [ 55 ] and promotes the incidence of dementia in pure synucleinopathies [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease

et al. 2022

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Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is well-established, the protein levels have received limited attention. Methods We here report the total plasma apoE and apoE isoform levels at baseline from a longitudinally (24 months) followed cohort including controls (n = 39), patients with stable amnestic mild cognitive impairment during 24 months follow up (MCI-MCI, n = 30), patients with amnestic MCI (aMCI) that during follow-up were clinically diagnosed with AD with dementia (ADD) (MCI-ADD, n = 28), and patients with AD with dementia (ADD) at baseline (ADD, n = 28). We furthermore assessed associations between plasma apoE levels with cerebrospinal fluid (CSF) AD biomarkers and α-synuclein, as well as both CSF and plasma neurofilament light chain (NfL), YKL-40 and kallikrein 6. Results Irrespective of clinical diagnosis, the highest versus the lowest apoE levels were found in APOE ε2/ε3 versus APOE ε4/ε4 subjects, with the most prominent differences exhibited in females. Total plasma apoE levels were 32% and 21% higher in the controls versus MCI-ADD and ADD patients, respectively. Interestingly, MCI-ADD patients exhibited a 30% reduction in plasma apoE compared to MCI-MCI patients. This decrease appeared to be associated with brain amyloid-β (Aβ42) pathology regardless of disease status as assessed using the Amyloid, Tau, and Neurodegeneration (A/T/N) classification. In addition to the association between low plasma apoE and low levels of CSF Aβ42, lower apoE levels were also related to higher levels of CSF total tau (t-tau) and tau phosphorylated at Threonine 181 residue (p-tau) and NfL as well as a worse performance on the mini-mental-state-examination. In MCI-ADD patients, low levels of plasma apoE were associated with higher levels of CSF α-synuclein and kallikrein 6. No significant correlations between plasma apoE and the astrocytic inflammatory marker YKL40 were observed. Conclusions Our results demonstrate important associations between low plasma apoE levels, Aβ pathology, and progression from aMCI to a clinical ADD diagnosis.

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Section: Discussionmentioning

confidence: 99%

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease

et al. 2022

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“…ELAs may produce chronic psychological stress and epigenetic modifications of multiple genes including those implicated in regulation of cholesterol levels and stress responses 36 . In this regard, some studies reported that apolipoprotein E, that it is involved in the formation of synapses and prevention of neuronal death, might be associated with decreased lipid levels, which in turn might be related to the severity of suicidal behavior 38 39 Nevertheless, some studies suggest that some cholesterol metabolites called oxysterols may cross the blood–brain barrier leading to modifications in central nervous system (CNS) cholesterol levels and lipid raft activity resulting in impairment of serotonin synaptic transmission 19 .…”

Section: Discussionmentioning

confidence: 99%

“…36 In this regard, some studies reported that apolipoprotein E, that it is involved in the formation of synapses and prevention of neuronal death, might be associated with decreased lipid levels, which in turn might be related to the severity of suicidal behavior. 38,39 Nevertheless, some studies suggest that some cholesterol metabolites called oxysterols may cross the blood-brain barrier leading to modifications in central nervous system (CNS) cholesterol levels and lipid raft activity resulting in impairment of serotonin synaptic transmission. 19 As a consequence of altered phospholipid and cholesterol contents in CNS, a study reported that violent suicide completers may display a lower gray matter lipid content in both ventral prefrontal and orbitofrontal cortex than nonviolent suicidal people.…”

Section: Main Findingsmentioning

confidence: 99%

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

et al. 2020

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Background Suicidality is one of the most common complications of mental disorders, so that the identification of potential biomarkers may be relevant in clinical practice. To date, the role of serum lipids and neutrophil/lymphocyte ratio (NLR) has been explored albeit with conflicting results. To the best of our knowledge, no study has explored lipid levels concomitantly with NLR in relation to violent suicide attempts. Therefore, we aimed to investigate whether serum lipid levels and NLR might be associated with the violent method of suicide attempts. Methods The study group consisted of 163 inpatients who attempted suicide. Blood samples were collected at the beginning of hospitalization to measure total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, very-low-density lipoprotein (VLDL), triglycerides, and NLR. Descriptive analyses of the total sample were performed. The included patients were divided into two groups according to violent/nonviolent method. Groups were compared in terms of lipid (MANCOVAs). Results Plasma levels of total cholesterol (F = 5.66; P = .02), LDL (F = 4.94; P = .03), VLDL (F = 5.66; P = .02), and NLR (F = 8.17; P < .01) resulted to be significantly lower in patients that used a violent method compared to patients who attempted suicide with a nonviolent method. Conclusions Low cholesterol, LDL, and VLDL levels as well as low NLR value were associated with a violent method of suicide attempt in patients with mental disorders. Further studies are needed to confirm these results.

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“…While the results of these studies in blood are somewhat inconsistent, most evidence now points to low plasma apoE predicting dementia and low plas a apoE as a io arker for Alzhei er s disease (Rasmussen, 2016). Increased plasma apoE has also been shown correlate with severity of suicidal behaviour (Asellus et al, 2016). The authors hypothesized this may be related to the regulation of apoE by stress and the role of stress in suicide severity.…”

Section: Discussionmentioning

confidence: 99%

ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort

Sabherwal

Föcking

English

et al. 2019

Schizophrenia Research

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Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 11 subjects who reported psychotic experiences at both age 11 and age 18 (n=38) with age-matched controls who only experienced psychotic experiences (PEs) at age 11 (n=38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a arker of Alzhei er s Disease, to be significantly up regulated (p<0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 11 children who experience PEs is associated with persistence psychotic experiences.

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Plasma apolipoprotein E and severity of suicidal behaviour

Cited by 13 publications

References 162 publications

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease

Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort

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