Plasma Apparatuses for Biomedical Applications

Kim, Hee‐Tak; Jin, Sewhan; Han, Gook-Hee; Kwon, Gi Chung; Choi, Jin Joo; Choi, Eun Ha; Uhm, Han S.; Cho, Guangsup

doi:10.1109/tps.2015.2388775

Cited by 36 publications

(19 citation statements)

References 32 publications

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“…Presently, plasma jets have been mostly applied in dermatology for treatment of skin cancer and for tissue regeneration and healing. Several atmospheric plasma devices especially designed and certified for clinical applications are now commercially available . However, for a specific medical application (wound healing or inactivation of specific tumor cells) normally a different kind of plasma source is required.…”

Section: Introductionmentioning

confidence: 99%

Study of Cold Atmospheric Plasma Jet at the End of Flexible Plastic Tube for Microbial Decontamination

Kostov

Nishime

Machida

et al. 2015

Plasma Processes & Polymers

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Recently, cold atmospheric plasmas have demonstrated very promising antimicrobial activity in vitro and in vivo including selective destruction of tumor cells. However, the size and the rigidity of most plasma systems limit the clinical application for treatments in internal organs or regions with difficult access (e.g., mouth). Here, we report a device that allows ignition of cold He plasma jet at the tip of 1 m long, 3.5 mm diameter, flexible plastic tube. It is connected to a dielectric enclosure where dielectric barrier discharge (DBD) is generated by a low‐frequency AC power supply. A thin wire at floating potential put inside the plastic tube assists the formation of plasma jet at the downstream tube end. The flexible tube can be kept and manipulated by hand without electric shock and thus the plasma jet can be easily directed to a target. Variation of duty cycle of the applied voltage signal allows precise adjustment of the discharge power. The anti‐microbial efficiency of plasma jet system with flexible tube was tested against fungus Candida albicans seeded on agar.

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Section: Introductionmentioning

confidence: 99%

Study of Cold Atmospheric Plasma Jet at the End of Flexible Plastic Tube for Microbial Decontamination

Kostov

Nishime

Machida

et al. 2015

Plasma Processes & Polymers

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“…Direct plasma sources-primarily dielectric barrier discharge (DBD) technology-use the human body as a counter electrode [6,15]. Indirect plasma sources generate plasma between two electrodes within a delivery device and the active components created by the plasma are transported to the target area [16][17][18][19][20][21]. These indirect delivery devices can vary from thin plasma needles to plasma jets and large torches, with different arrangements of electrodes.…”

Section: Introductionmentioning

confidence: 99%

“…Our laboratory developed two types of FE-DBD devices [18]. One uses a 1-mm-thick quartz plate and the other uses a copper wire coated with 1-mm-thick foam rubber for insulation against high voltage.…”

Section: Introductionmentioning

confidence: 99%

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Wearable Plasma Pads for Biomedical Applications

et al. 2017

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A plasma pad that can be attached to human skin was developed for aesthetic and dermatological treatment. A polyimide film was used for the dielectric layer of the flexible pad, and high-voltage and ground electrodes were placed on the film surface. Medical gauze covered the ground electrodes and was placed facing the skin to act as a spacer; thus, the plasma floated between the gauze and ground electrodes. In vitro and in vivo biocompatibility tests of the pad showed no cytotoxicity to normal cells and no irritation of mouse skin. Antibacterial activity was shown against Staphylococcus aureus and clinical isolates of methicillin-resistant S. aureus. Furthermore, skin wound healing with increased hair growth resulting from increased exogenous nitric oxide and capillary tube formation induced by the plasma pad was also confirmed in vivo. The present study suggests that this flexible and wearable plasma pad can be used for biomedical applications such as treatment of wounds and bacterial infections.

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“…The majority of such applications are related to food [4,5,6] and medicine [7,8,9] but are by no means restricted solely to these. Over this period of time, a variety of plasma-generating devices has been described in the scientific literature [10,11,12] and numerous tests to inactivate a wide range of micro-organisms have been conducted. This has led to the generation of a large data resource which could in principle serve in the design of gas plasma-based disinfection processes.…”

Section: Introductionmentioning

confidence: 99%