Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations

Gehlen, Heidrun; Sundermann, Till; Rohn, Karl; Štádler, P

doi:10.1016/j.jvc.2007.10.003

Cited by 17 publications

(28 citation statements)

References 11 publications

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“…Similarly, in our study there was no difference in Cp ANP between Group A and Group C (control group). Furthermore, Cp ANP in our control group was similar to the concentrations reported by Gehlen et al (2007) in healthy Warmblood horses and similar to those reported in healthy Finnhorse trotters (18 ± 1 pg/mL, mean ± SE) and healthy Standardbreds (15 ± 2 pg/mL, mean ± SE) (Kokkonen et al, 1995). It could therefore be inferred that horses with cardiac disease and normal chamber dimensions could not reliably be differentiated from healthy horses by use of Cp ANP .…”

Section: Discussionsupporting

confidence: 88%

“…In Group A, the Cp ANP was slightly lower than values reported by Gehlen et al (2007) in Warmblood horses with valvular regurgitation and normal chamber dimensions (20.1 ± 5.6 pg/mL, mean ± SD). In the latter study, Cp ANP in this group was not significantly different from Cp ANP in healthy Warmblood horses (21.0 ± 5.4 pg/mL) (Gehlen et al, 2007). Similarly, in our study there was no difference in Cp ANP between Group A and Group C (control group).…”

Section: Discussioncontrasting

confidence: 64%

“…Notably, Cp ANP in Group B was markedly higher than the Cp ANP reported by Gehlen et al (2007) in horses with enlarged LA but normal LV dimensions (22.9 ± 11.0 pg/mL), and in horses with both LA and LV enlargement (27.6 ± 17.4 pg/mL), neither of which was significantly different from healthy Warmblood horses (21.0 ± 5.4 pg/mL) in the aforementioned study.…”

Section: Discussioncontrasting

confidence: 61%

“…More recently, it has been shown that Cp ANP may be slightly elevated in horses with valvular regurgitation associated with left atrial (LA) enlargement or combined LA and left ventricular (LV) dilation, compared to healthy horses (Gehlen et al, 2007). However, the use of ANP as a cardiac biomarker has not yet been fully investigated in horses.…”

Section: Introductionmentioning

confidence: 99%

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Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study

Trachsel

Grenacher

Weishaupt

et al. 2012

The Veterinary Journal

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Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp(ANP)) were compared between horses with heart disease but normal chamber size and function (Group A; n=6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n=5), and horses with no clinically apparent cardiovascular disease (Group C; n=13). The median (min-max) for Cp(ANP) was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to ) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp(ANP) in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp(ANP) in horses might be useful in detecting LA enlargement and that Cp(ANP) could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results. Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp ANP ) were compared between horses with heart disease but normal chamber size and function (Group A; n = 6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n = 5), and horses with no clinically apparent cardiovascular disease (Group C; n = 13). The median (min-max) for Cp ANP was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to Group A (12.5 (6.3-19.8) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp ANP in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp ANP in horses might be useful in detecting LA enlargement and that Cp ANP could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study

Trachsel

Grenacher

Weishaupt

et al. 2012

The Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Furthermore, since ANP was not found to be diagnostic in horses with valvular disease and equine (and other) BNP and NT-proBNP are not available, this area is still ill-explored in larger animals. 113 …”

Section: Natriuretic Peptide Testing In Veterinary Medicinementioning

confidence: 99%