Plasma atrial natriuretic peptide concentrations in horses with heart disease: A pilot study

Abstract

Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp(ANP)) were compared between horses with heart disease but normal chamber size and function (Group A; n=6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n=5), and horses with no clinically apparent cardiovascular disease (Group C; n=13). The median (min-max) for Cp(ANP) was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to ) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp(ANP) in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp(ANP) in horses might be useful in detecting LA enlargement and that Cp(ANP) could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results. Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp ANP ) were compared between horses with heart disease but normal chamber size and function (Group A; n = 6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n = 5), and horses with no clinically apparent cardiovascular disease (Group C; n = 13). The median (min-max) for Cp ANP was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to Group A (12.5 (6.3-19.8) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp ANP in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp ANP in horses might be useful in detecting LA enlargement and that Cp ANP could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results.

Echocardiographic Assessment of Left Atrial Size and Function in Warmblood Horses: Reference Intervals, Allometric Scaling, and Agreement of Different Echocardiographic Variables

“…However, some of the approaches are not very practical for daily clinical use. Therefore, we chose an allometric scaling approach that corrects echocardiographic variables to a standard body weight of 500 kg and allows intuitive interpretation of weight‐corrected variables . The results of this study show that allometric scaling of echocardiographic measurements of LA size in Warmblood horses is effective and eliminates the significant relationship of LA dimensions to body weight.…”

Biomarcadores cardiacos como ayuda diagnóstica en las cardiopatías

“…Debido a que la secuencia de aminoácidos del anp está altamente conservada entre especies, se pueden usar los ensayos desarrollados para humanos en la medición de estas sustancias en perros [38], al igual que se están validando para otras especies como los equinos [39].…”

Biomarkers for differentiation of causes of respiratory distress in dogs and cats: Part 1 – Cardiac diseases and pulmonary hypertension

“…Concentrations of C‐ANP have been shown to be increased in cows and horses with cardiac stresses from various causes . Concentrations of ANP decreased significantly after fluid resuscitation in hypovolemic adult horses, which was thought to be due to secondary catecholamine induced ANP production …”