1980
DOI: 10.1111/j.1365-2125.1980.tb01090.x
|View full text |Cite
|
Sign up to set email alerts
|

Plasma binding of disopyramide.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
13
0

Year Published

1982
1982
1989
1989

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 24 publications
(14 citation statements)
references
References 15 publications
1
13
0
Order By: Relevance
“…At therapeutic drug concentrations the drug exhibits concentration dependent plasma binding (Hinderling et al, 1974;Cunningham et al, 1977Cunningham et al, , 1978Meffin et al, 1979;David et al, 1980). Disopyramide clearance is dependent upon the drug free fraction rather than total drug concentrations (Hinderling & Garrett 1976;Cunningham et al, 1977Cunningham et al, , 1978Meffin et al, 1979;Bryson et al, 1982b).…”
Section: Introductionmentioning
confidence: 99%
“…At therapeutic drug concentrations the drug exhibits concentration dependent plasma binding (Hinderling et al, 1974;Cunningham et al, 1977Cunningham et al, , 1978Meffin et al, 1979;David et al, 1980). Disopyramide clearance is dependent upon the drug free fraction rather than total drug concentrations (Hinderling & Garrett 1976;Cunningham et al, 1977Cunningham et al, , 1978Meffin et al, 1979;Bryson et al, 1982b).…”
Section: Introductionmentioning
confidence: 99%
“…Blood samples were obtained by venepuncture and plasma was separated by centrifugation. The binding was studied at a single disopyramide concentration as the drug shows concentration-dependent binding over its therapeutic range (Cunningham etal., 1977;Karim et al, 1978;Meffin et al, 1979;David et al, 1980 Preliminary analysis showed that sex differences were in general of low importance relative to differences between age groups. In healthy adults (group 4), however, females had lower mean scores on all variables (Blain et al, 1981;Piafsky & Borga, 1977).…”
Section: Effect Of Age and Plasma Concentrations Of Albumin And A I-amentioning
confidence: 99%
“…However, both studies show that the concentration of DP cannot be used to predict that of MND in plasma, and the need for concomitant determination of both should be thoroughly considered. Concentration dependent plasma protein binding and interindividual binding variations for DP are reported by a number of authors (Chien et al, 1974, Hinderling et al, 1974Cunningham et al, 1977;Meffin et al, 1979;David et al, 1980;Aitio, 1981;Johnston & Hamer, 1982). Very little is known about the main metabolite MND which also possesses some antiarrhythmic and electrophysiological activity (for review, see Koch-Weser, 1979;Brown & Shand, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…The value of measuring total plasma concentrations of DP can be further questioned by the fact that its plasma protein binding shows a wide intersubject and concentration dependent variability already within the assumed therapeutic range (Meffin et al, 1979;David et al, 1980;Lima et al, 1981).…”
Section: Introductionmentioning
confidence: 99%