Plasma bioscience for medicine, agriculture and hygiene applications

Abstract

Nonthermal biocompatible plasma (NBP) sources operating in atmospheric pressure environments and their characteristics can be used for plasma bioscience, medicine, and hygiene applications, especially for COVID-19 and citizen. This review surveyed the various NBP sources, including a plasma jet, micro-DBD (dielectric barrier discharge) and nanosecond discharged plasma. The electron temperatures and the plasma densities, which are produced using dielectric barrier discharged electrode systems, can be characterized as 0.7 ~ 1.8 eV and (3-5) × 10 14-15 cm −3 , respectively. Herein, we introduce a general schematic view of the plasma ultraviolet photolysis of water molecules for reactive oxygen and nitrogen species (RONS) generation inside biological cells or living tissues, which would be synergistically important with RONS diffusive propagation into cells or tissues. Of the RONS, the hydroxyl radical [OH] and hydrogen peroxide H 2 O 2 species would mainly result in apoptotic cell death with other RONS in plasma bioscience and medicines. The diseased biological protein, cancer, and mutated cells could be treated by using a NBP or plasma activated water (PAW) resulting in their apoptosis for a new paradigm of plasma medicine.

The role of metals in the deposition of long‐lived reactive oxygen and nitrogen species into the plasma‐activated liquids

“…In the last decade, it has been demonstrated that the RONS deposited into liquids can have antitumor/cancer, antibacterial and antimicrobial effect, and can induce oxidative stress to cells. An overview of the demonstrating studies has been given in Ref., [ 1,2 ] which indicate that the main role is played by the long‐lived RONS either directly or indirectly. The disinfecting property of PAL has been attributed to the synergistic effect of different RONS, [ 3,4 ] while in several studies, the emphasize is given to the pH of the solution or/and the peroxynitrite, peroxynitrous acid (ONOOH) and peroxynitric acid ($${{\rm{O}}}_{2}$$NOOH), which are created from the reaction of $${{\rm{H}}}_{2}{{\rm{O}}}_{2}$$ with $${\text{NO}}_{2}^{-}$$ under acidic conditions.…”

Enhancing seed germination and growth parameters of cauliflower (Brassica oleracea, variety Botrytis) using plasma-activated water

“…Additionally, OH (A 2 ∑ + → X 2 Π) radicals is prominently seen at 309 nm [27] in the spectrum of the gliding arc discharge which plays a crucial role in plasma chemical reactions such as the oxidation of gas and liquid pollutants [28]. The nitric oxide gamma band NO γ (A 2 ∑ + → X 2 Π) is observed in 200 to 280 nm [28][29][30].…”

Effect of different process conditions on the physicochemical and antimicrobial properties of plasma-activated water

“…RONS are considered to play a major role in the application of PAW in agriculture, medical, and food, and in biological sciences [31]. As shown in figure 4(a), the concentration of H 2 O 2 in PAW was decreased significantly (P < 0.05) as storage time was extended.…”

“…This may be due to the fact that the short-lived active substance in PAW is not completely dissipated in a short period of time, while prolonged treatment causes persistent damage to the bacterial cell structure and reduces the presence of sublethal bacteria. It was reported that low-temperature storage is conducive to the disinfection ability of PAW, but storage for a long time will weaken it, because more active substances are dissipated during storage [31,34].…”