Plasma brain-derived neurotrophic factor levels are increased in patients with tinnitus and correlated with therapeutic effects

Xiong, Hao; Yang, Haidi; Liang, Maojin; Ou, Yongkang; Huang, Xiayin; Cai, Yixi; Lai, Lan; Pang, Jiaqi; Zheng, Yiqing

doi:10.1016/j.neulet.2016.04.032

Cited by 17 publications

(11 citation statements)

References 33 publications

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“…When patients with tinnitus were classified as mild or severe according to the tinnitus handicap inventory (THI) score, those with mild tinnitus had higher plasma BNDF levels than those with severe tinnitus and the control group, and patients with lower hospital anxiety and depression scale (HADS) scores had low THI scores and high plasma BDNF levels [ 10 ]. In another study, plasma BDNF levels in patients with tinnitus were higher than those in the control group, and decreased after TRT in patients with severe tinnitus [ 84 ]. Plasma BDNF levels showed significant results in most studies, but were not related to the psychometric score [ 76 ].…”

Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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Tinnitus is associated with increased social costs and reduced quality of life through sleep disorders or psychological distress. The pathophysiology of chronic subjective tinnitus, which accounts for most tinnitus, has not been clearly elucidated. This is because chronic subjective tinnitus is difficult to evaluate objectively, and there are no objective markers that represent the diagnosis or therapeutic effect of tinnitus. Based on the results of studies on patients with chronic subjective tinnitus, objective and measurable biomarkers that help to identify the pathophysiology of tinnitus have been summarized. A total of 271 studies in PubMed, 303 in EMBASE, and 45 in Cochrane Library were found on biomarkers related to chronic subjective tinnitus published until April 2021. Duplicate articles, articles not written in English, review articles, case reports, and articles that did not match our topic were excluded. A total of 49 studies were included. Three specimens, including blood, saliva, and urine, and a total of 58 biomarkers were used as indicators for diagnosis, evaluation, prognosis, and therapeutic effectiveness of tinnitus. Biomarkers were classified into eight categories comprising metabolic, hemostatic, inflammatory, endocrine, immunological, neurologic, and oxidative parameters. Biomarkers can help in the diagnosis, measure the severity, predict prognosis, and treatment outcome of tinnitus.

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Section: Biomarkers In Chronic Subjective Tinnitusmentioning

confidence: 99%

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Kang

Kim

Park

et al. 2021

IJMS

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“…Recent publications demonstrated an increase of BDNF marker in tinnitus patients and rodents. [8,16] In this way, ELISA analysis of plasma demonstrated a significant increase of the BDNF tinnitus biomarker at 774.6 ± 26.5 pg/mL of plasma in the salicylate+TLD group, whereas the BDNF concentration in control mice was 568.1 ± 20.2 pg/mL of plasma 2 h after salicylate administration. Moreover, TLD treatment significantly reduced BDNF plasma concentration at 610.2 ± 12.1 pg/mL in the salicylate+TLD group.…”

Section: Tld Decreases the Spontaneous Activity Of The Pac And Tinnitus Biomarker In Salicylate-induced Tinnitus Modelmentioning

confidence: 83%

3,6’-Dithiothalidomide Reduces Tinnitus Phenotype in Two Different Mouse Preclinical Models of Tinnitus

González-González¹,

Cazevieille²

2020

J Community Prev Med

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Background: Tinnitus is the perception of a sound in the absence of external stimulation. Tinnitus is a common consequence of damage to the auditory periphery, affecting around 5-12% of the population and inducing intolerable discomfort. Today, no treatment exists to cure tinnitus. From an electrophysiology point of view, tinnitus leads to auditory brainstem responses (ABRs) wave modifications and spontaneous activity changes of the primary auditory cortex (PAC) in human and rodents. Moreover, plasma brain-derived neurotrophic factor (BDNF) levels vary with the severity of tinnitus, suggesting that plasma BDNF level can be used as a biomarker to objectively evaluate tinnitus in rodent and humans. Several publications suggested that tinnitus is closely related to auditory system inflammation and proinflammatory cytokine TNF-α. Results: we evaluated the efficacy of a novel thalidomide-based TNF-α lowering agent, the 3,6'-dithiothalidomide (TLD) in two different preclinical models of tinnitus. We observed that TLD treatment increased the % of startle GAP suppression, increased ABR wave I amplitude and decreased wave IV latency, decreased spontaneous activity of PAC, and significantly decrease plasma BDNF concentration in the salicylate-induced and noise-induced tinnitus mouse models. Conclusions: Our data confirm that proinflammatory cytokines are directly linked to tinnitus phenotype suggesting that inflammatory pharmacological modulators could be a promising therapy targeting tinnitus disorder.

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“…Some studies found that the BDNF concentration in the tinnitus group was higher than that in the normal control group,[ 64 ] but others have found otherwise. [ 56 ] Some studies have found that the BDNF levels were not related to the severity of tinnitus,[ 50 ] whereas some others have shown that BDNF concentration in the mild tinnitus group was higher than that in the severe tinnitus and the normal control groups. [ 73 ] As we know, BDNF prevents neuronal damage and apoptosis, improves the pathologic state of neurons, and promotes the regeneration and differentiation of neurons after injury, damage to the auditory nervous system is an important pathologic basis of tinnitus.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Studies in Tinnitus-Related Gene Research

Zhong

Zeng

et al. 2021

Noise and Health

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Objective: Summarize and analyze the current research results of tinnitus-related genes, explore the potential links between the results of each study, and provide reference for subsequent studies. Methods: Collect and sort out the research literature related to tinnitus genes included in PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang Data Knowledge Service Platform before December 31, 2019. Then the relevant contents of the literature were sorted out and summarized. Results: Fifty-one articles were finally selected for analysis: 31 articles (60.8%) were classified as researches on animal models of tinnitus, and 20 (39.2%) as researches on tinnitus patients. Existing studies have shown that genes related to oxidative stress, inflammatory response, nerve excitation/inhibition, and nerve growth are differentially expressed in tinnitus patients or animal models, and have presented the potential links between genes or proteins in the occurrence and development of tinnitus. Conclusion: The research on tinnitus-related genes is still in the exploratory stage, and further high-quality research evidence is needed.

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Plasma brain-derived neurotrophic factor levels are increased in patients with tinnitus and correlated with therapeutic effects

Cited by 17 publications

References 33 publications

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

Objective and Measurable Biomarkers in Chronic Subjective Tinnitus

3,6’-Dithiothalidomide Reduces Tinnitus Phenotype in Two Different Mouse Preclinical Models of Tinnitus

Analysis of Studies in Tinnitus-Related Gene Research

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