Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction

Maeda, Keiko; Tsutamoto, Takayoshi; Wada, Atsuyuki; Hisanaga, Tomoko; Kinoshita, Masahiko

doi:10.1016/s0002-8703(98)70041-9

Cited by 704 publications

(429 citation statements)

References 29 publications

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“…[1][2][3] In several studies, plasma ANP and BNP concentrations have been found to be decreased in obese subjects. [4][5][6][7] Additionally, an increase in natriuretic peptides (NPs) has been reported to parallel an increase in blood pressure.…”

Section: Introductionmentioning

confidence: 99%

The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension

Cikim

2007

J Hum Hypertens

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Hypertension is frequently associated with obesity and natriuretic peptide levels are reported to decrease in obese subjects. Both the lower brain natriuretic peptide (BNP) concentration and insulin resistance are suggested to be associated with hypertension. However, their involvement in obesity-related hypertension has not been clearly defined. Forty-four obese women (21 normotensive and 23 hypertensive) and 25 healthy women matched for age were included in the study. Anthropometrical parameters were determined. Serum BNP, fasting insulin and glucose concentrations, and lipid parameters were evaluated. Insulin resistance was calculated using Homeostasis Model Assessment (HOMA) and Quantative Insulin Sensitivity Check Index (QUICKI) formulations. Within the obese groups, HOMA and QUICKI reflected the increased insulin resistance in hypertensive obese subjects with a significant correlation to blood pressure. The decrease in BNP in the obese groups was in favour of the hypertensive obese subjects (31.4376.43; 26.3674.29; and 17.5173.08 pg/ ml, respectively) with a fractional statistical significance between the hypertensive obese group and the controls (P ¼ 0.047). Only for the obese hypertensive group, fasting glucose, HOMA and QUICKI were significantly correlated with BNP. Moreover, fasting plasma glucose (R 2 ¼ 0.22, P ¼ 0.007) and fasting plasma insulin (R 2 ¼ 0.39, P ¼ 0.03) were independently correlated with BNP only for the obese hypertensive group. It can be concluded that the decrease in BNP concentrations in the obese hypertensive subjects seem to be well correlated with the insulin resistance.

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Section: Introductionmentioning

confidence: 99%

The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension

Cikim

2007

J Hum Hypertens

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“…Consequently it reflects the decompensated state of the ventricles. [7][8][9] Plasma levels of BNP correlate with functional class according to the NYHA and can be used to differentiate cardiac from pulmonary dyspnoea. 10,11 Plasma levels after VAD implantation are thought to give an indication of the extent of unloading of the ventricles.…”

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confidence: 99%

Left ventricular assist device: a functional comparison with heart transplantation

Pruijsten

Jonge²,

Kirkels³

et al. 2008

NHJL

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Background. A growing number of patients with end-stage heart failure undergo implantation of ventricular assist devices as a bridge to heart transplantation. Objectives. In this study we investigated whether functional and haemodynamic recovery after implantation is sufficient to warrant the use of them as long-term alternative to heart transplantation. Methods. We compared peak VO 2 of a group of patients three months after implantation of a ventricular assist device and three months after heart transplantation. Furthermore, we analysed the degree of haemodynamic recovery, by comparing plasma levels of BNP and creatinine before and after implantation of the device. Results. After implantation of a ventricular assist device, exercise capacity improved considerably; three months after implantation peak VO 2 was 20.0±4.9 ml/kg/min (52% of predicted for age and gender). After heart transplantation exercise capacity improved even further; 24.0±3.9 ml/ kg/min (62% of predicted for age and gender) (p<0.001). In the three months after implantation, BNP plasma levels decreased from 570±307 pmol/l to 31±25 pmol/l and creatinine levels decreased from 191±82 µmol/l to 82±25 µmol/l, indicating significant unloading of the ventricles and haemodynamic recovery. Conclusion. With regard to functional and haemodynamic recovery, the effect of implantation of a ventricular assist device is sufficient to justify its use as an alternative to heart transplantation. (Neth Heart J 2008;16:41-6.)

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“…9, 10 B-type natriuretic peptide was measured by the Shionoria assay method (inter-and intra-assay coefficients of variation 0.7%-1.4% and 2.8%-3.7%, respectively). 2 When new or worsening symptom(s) and/or sign(s) were identified, patients were further evaluated by optimal use of chest x-ray and/or echocardiography. Efforts were made to investigate the precipitating factors that led to HF decompensation.…”

Section: Study Protocolmentioning

confidence: 99%

“…1 Levels of BNP reflect the severity of the hemodynamic parameters 2,3 and correlate with the New York Heart Association (NYHA) classification 4 of patients with heart failure (HF). Plasma BNP and N-terminal (NT)-proBNP levels, however, are highly dynamic, likely nonlinear, and highly complex.…”

Section: Introductionmentioning

confidence: 99%

“…In patients with chronic HF, however, little is known about the relationship of body fluid status with the levels and fluctuations of BNP over the long term. [6][7][8] The main purpose of this study was to examine the longitudinal relationship between clinically determined body fluid status and BNP level in patients with chronic HF (1) to explore the intra individual fluctuations in plasma BNP levels over time and (2) to determine whether the levels reliably reflect both decompensation and improvement in the individual patient's condition.…”

Section: Introductionmentioning

confidence: 99%

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Relation of body fluid status to B‐type natriuretic peptide levels in patients with chronic heart failure during long‐term follow‐up

Kataoka

2006

Clinical Cardiology

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SummaryBackground: Little is known about the relationship of body fluid status with the levels and fluctuations of B-type natriuretic peptide (BNP) over the long term.Hypothesis: If BNP is to become useful for monitoring of patients with chronic heart failure (HF), the levels should reliably reflect both decompensation and improvement in the patient's condition.Methods: Forty-six patients with chronic HF who were stable at study entry but had previous decompensation were recruited and followed up between June 2003 and September 2005. At each visit, they were examined for BNP level and HF-related signs of body fluid retention based on physical evaluation and pleural ultrasonography.Results: During the study period, 26 patients developed decompensation and 20 maintained a stable clinical course. In the 26 decompensated patients, BNP levels fluctuated widely (110 ± 73.7 pg/ml; range 25-290 pg/ml) even during stable periods. In all but three patients in this group, the maximum BNP level during decompensation was higher than that reached during stable periods. The BNP levels also fluctuated widely (180 ± 123 pg/ml; range 16-489 pg/ml) in the 20 stable patients with HF. In all but one patient in this group, the BNP lev-

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Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction

Cited by 704 publications

References 29 publications

The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension

The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension

Left ventricular assist device: a functional comparison with heart transplantation

Relation of body fluid status to B‐type natriuretic peptide levels in patients with chronic heart failure during long‐term follow‐up

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