Plasma brain natriuretic peptide, platelet parameters, and cardiopulmonary function in chronic obstructive pulmonary disease

Abstract

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with worldwide occurrence and high disability and mortality rate. It occurs mostly in the elderly population with pulmonary heart disease, type II respiratory failure, and other serious complications. AIM To investigate the correlation of plasma brain natriuretic peptide (BNP) and platelet parameters with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease. METHODS From June 2016 to June 2019, 52 patients with COPD-pulmonary heart disease (pulmonary heart disease group), 30 patients with COPD (COPD group), and 30 healthy individuals (control group) in our hospital were enrolled in the study. The pulmonary heart disease group was further divided into subgroups according to cardiac function classification and pulmonary artery pressure. Plasma BNP and platelet parameters were estimated and compared among each group and subgroup. The correlation of plasma BNP and platelet parameters with cardiac function classification and pulmonary artery pressure was then analyzed. RESULTS In the pulmonary heart disease group, the COPD group, and the control group, the levels of plasma BNP, platelet distribution width (PDW), and mean platelet volume (MPV) showed a decreasing trend ( P < 0.05), while an increasing trend was found in platelet count (PLT) and plateletcrit (PCT) levels among the three groups ( P < 0.05). In the pulmonary hypertension mild, moderate, and severe subgroups, the levels of plasma BNP, PDW, and MPV showed an increasing trend ( P < 0.05), while a decreasing trend was observed in PLT levels ( P < 0.05); however, PCT levels showed no significant difference among the three subgroups ( P > 0.05). In the cardiac function grade I, II, III, and IV subgroups, the levels of plasma BNP, PDW, and MPV showed an increasing trend ( P < 0.05), while a decreasing trend was noted in PLT and PCT levels among the four subgroups ( P < 0.05). Correlation analysis showed that the levels of plasma BNP, PDW, and MPV in patients with pulmonary heart disease were positively correlated with their pulmonary artery pressure ( P < 0.05), while PLT was negatively correlated with their pulmonary artery pressure ( P < 0.05). Moreover, plasma BNP, PDW, and MPV levels were positively correlated with cardiac function grade ( P < 0.05) of these patients, while PLT and PCT levels were negatively correlated with their cardiac function grade ( P < 0.05). CONCLUSION Plasma BNP and PLT parameters are significantly correlated with the cardiac function and pulmonary hypertension in patients with COPD a...

Association of complete blood count parameters with the risk of incident pulmonary heart disease in pneumoconiosis: a retrospective cohort study

“…Guo et al found that plasma PDW and MPV levels were positively correlated with pulmonary artery pressure and cardiac function grade. 25 A study conducted on children has come to a similar conclusion that MPV, PDW and PCT are positively correlated with right ventricular diameter and may be good predictors of prognosis in pulmonary hypertension. 26 A single-centre retrospective cohort study found that higher baseline PLT and PCT, but not MPV, were associated with increased cardiovascular mortality 27 which is similar to our finding.…”

Diagnostic values of serum BNP, PTX3, and VEGF in acute pulmonary embolism complicated by pulmonary artery hypertension and their correlations with severity of pulmonary artery hypertension

“…Besides, Pearson correlation analysis signified that serum BNP levels were positively correlated with PAP grading in APE‐PAH patients, and serum BNP levels had a diagnostic power in patients. As reported, plasma BNP parameters are bound up with pulmonary hypertension and cardiac function in patients with chronic obstructive pulmonary disease (COPD) and pulmonary heart disease, implying that BNP could reflect the health condition of patients and guide their treatment 21 . A study including 157 patients with portal hypertension or decompensated cirrhosis has disclosed that BNP levels are elevated in patients with high right ventricular systolic pressures, thus predicting portopulmonary hypertension (PoPH) 22 .…”

“…As reported, plasma BNP parameters are bound up with pulmonary hypertension and cardiac function in patients with chronic obstructive pulmonary disease (COPD) and pulmonary heart disease, implying that BNP could reflect the health condition of patients and guide their treatment. 21 A study including 157 patients with portal hypertension or decompensated cirrhosis has disclosed that BNP levels are elevated in patients with high right ventricular systolic pressures, thus predicting portopulmonary hypertension (PoPH). 22 Moreover, BNP measurement has been demonstrated to have utility in the early diagnosis of PoPH, with a cut‐off value of 29.1 pg/mL for BNP in the prediction of the disease.…”