Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia

Viana, Adriana M.; Campos, Antônio Carlos de; Morlin, Mayra T.; Chin, Veronica Kei Len

doi:10.1016/j.tripleo.2005.01.005

Cited by 17 publications

(12 citation statements)

References 17 publications

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“…Several haemodynamic studies have been carried out in patients subjected to local anaesthetic injection with a vasoconstrictor [18][19][20]. While some have reported no significant changes in either blood pressure (systolic and diastolic) or heart rate, others did and some authors have suggested that changes are dependent upon the injected vasoconstrictor dose [21].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Akinmoladun

Okoje

Akinosun

et al. 2012

J. Maxillofac. Oral Surg.

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Introduction The systemic effects of adrenaline administered during dental local anesthesia have been the subject of many studies. The purpose of this study was to investigate the haemodynamic and metabolic effects attributable to adrenaline injected during local anesthesia in dental extraction patients. Methods Apparently medically fit patients were included and randomized into two groups. Participants had breakfast before coming in for tooth extraction. The weight, height, blood pressure and pulse rate were measured and blood sample taken before administration of local anaesthetic injections. Blood pressure, pulse and blood sample were again taken at 15 and 30 min. Results While the adrenaline group showed a modest increase between pre-and post-drug administration states, the control group showed no difference in median systolic blood pressures. Both groups showed a slight increase in diastolic blood pressure observed between pre-and postdrug administration states. Also both groups showed no significant difference in median pulse rate throughout. Although blood glucose values were widely dispersed in the pre-drug administration state in both groups, the control group showed no difference in median values throughout. However, a modest increase was observed in the adrenaline group between pre-and post-drug administration states, which persisted beyond 30 min. Conclusion The patients treated with local anesthesia with adrenaline showed a response similar to that observed in the control group.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Akinmoladun

Okoje

Akinosun

et al. 2012

J. Maxillofac. Oral Surg.

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show abstract

“…Many hemodynamic studies were carried out on patients subjected to local anesthesia with vasoconstrictor. [13,14,15,16] No significant changes were recorded in either blood pressure (systolic and diastolic) or heart rate. However, some authors suggested that such changes were dependent upon the injected vasoconstrictor dose.…”

Section: Discussionmentioning

confidence: 96%

Hemodynamic Effects of Local Anesthesia and its Possible Correlation with Chromogranin A

Al-Saffar¹,

Al–Sandook²,

Taha³

2014

AJPS

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Aim: To study the effects of local anesthesia on blood pressure in patients undergo extraction of maxillary teeth under infiltration local anesthesia and to compare the level of salivary chromogranin A before and after administration of local anesthesia and its possible correlation with hemodynamic effects of local anesthesia. Materials and Methods: A total of 26 patients (18 female, 8 male) who need tooth extraction under infiltration local anesthesia were examined in two situations (pre and post local anesthetic administration). For each patient salivary sample was collected by salivette to estimate the level of chromogranin A using ELISA Kits. For all patients, the blood pressure and pulse rate were measured before and after administration of local anesthesia using automatic blood pressure recorder. Results: the results showed significant differences between salivary chromogranin A for patients before the administration of local anesthesia (580.33 ± 130.42) ng/ml and after the administration of local anesthesia (674.51+ 130.93) ng/ml with p < 0.05. The results also showed that the mean value of blood pressure (systolic and diastolic blood pressure) lowered after administration of local anesthesia but with no significant differences (p > 0.05) with pre -local anesthetic value. The pulse rate was increase in it is value after local anesthetic administration with a significant differences (p < 0.05) than pre -anesthetic value. Conclusions: tooth extraction and administration of infiltration local anesthesia caused hypotension with no significant effect (p > 0.05) while it caused increase in pulse rate with a significant effect (p < 0.05). Administration of infiltration local anesthesia caused significant effects on salivary chromogranin A levels, also this study showed that there was significant inverse correlation between systolic blood pressure and chromogranin A levels(p < 0.05) after administration of infiltrations local anesthesia during dental treatments (tooth extraction).

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“…[1121314] Since the administration of LA with epinephrine elicited an increase in blood glucose levels even in patients with normal glucose tolerance, such administration may cause further increases in blood glucose levels in patients with diabetes. [1516] In the present study, blood glucose levels between different time periods were significantly increased in controlled type II diabetic patients treated under 2% lignocaine HCl with 1:200,000 epinephrine.…”

Section: Discussionmentioning

confidence: 99%

“…[123456789101112131415161718192021222324252627] The present study was done to comparatively evaluate the effects of 2% lignocaine and 2% lignocaine with 1:200,000 epinephrine on blood glucose level and hemodynamics in patients undergoing multiple tooth extractions.…”

Section: Introductionmentioning

confidence: 99%

Comparing hemodynamic and glycemic response to local anesthesia with epinephrine and without epinephrine in patients undergoing tooth extractions

Kaur

Bahl

Kaura

et al. 2016

Natl J Maxillofac Surg

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Introduction:Lignocaine with epinephrine as local anesthetic (LA) provides hemostasis and decreases the risk of systemic toxicity. The purpose of the present study was to investigate and compare the response of lignocaine with and without epinephrine to evaluate hemodynamic and metabolic response in normotensive and type II controlled diabetic patients.Material and Methods:A total of 50 patients (25 healthy and 25 controlled type II diabetics) undergoing multiple tooth extractions (age group of 20–80 years) were included in this prospective, randomised, clinical study. On their first visit, the patients were given 2% lignocaine HCl with 1:200,000 epinephrine, and 2% lignocaine HCl was given on the second visit, to carry out tooth extractions. Blood pressure (BP), pulse rate, oxygen saturation, and blood glucose estimations were done at definite intervals (before, immediately after, and 20 min after the administration of LA) on both the visits.Results:The increase in blood glucose concentration following the administration of 2% lignocaine HCl with 1:200,000 epinephrine was statistically significant (P < 0.05) in controlled diabetic patients. Statistically significant variability in diastolic BP (DBP) was also noted in controlled diabetic patients. Both systolic BP and DBPs were statistically significantly elevated after the administration of 2% lignocaine HCl.Conclusion:2% lignocaine HCl with 1:200,000 epinephrine in type II diabetics and 2% lignocaine HCl should be used with caution in normotensive as well as type II controlled diabetic patients.

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Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia

Cited by 17 publications

References 17 publications

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Evaluation of the Haemodynamic and Metabolic Effects of Local Anaesthetic Agent in Routine Dental Extractions

Hemodynamic Effects of Local Anesthesia and its Possible Correlation with Chromogranin A

Comparing hemodynamic and glycemic response to local anesthesia with epinephrine and without epinephrine in patients undergoing tooth extractions

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