Plasma Cell Neoplasms

McKenna, Robert W.; Kroft, Steven H.

doi:10.1016/b978-0-7216-0040-6.00025-3

Cited by 58 publications

(114 citation statements)

References 182 publications

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“…49,50 This distribution of genetic abnormalities is similar to the reported literature and does not indicate a unique subtype of plasma cell myeloma. 46,49,50 Aside from large numbers of IgG4 þ plasma cells, the histological features of bone marrows and soft tissue debridement specimens did not show any characteristics of IgG4-related disease, such as lymphoplasmacytic inflammation, lymphoid follicles with expanded germinal centers, obliterative phlebitis, or prominent cellular fibrosis, composed of activated fibroblasts, lymphocytes, and plasma cells. 10,20,[51][52][53][54][55][56][57][58] Despite sustained high serum levels of IgG4, none of the patients fulfilled diagnostic criteria for IgG4-related systemic disease.…”

Section: Discussionmentioning

confidence: 96%

“…46 All cases of CD56-positive myeloma had a complex karyotype. Lack of CD56 expression in plasma cell myeloma has previously been associated with worse outcome; however, recent studies of patients treated with high-dose chemotherapy did not find a significant difference in patient survival.…”

Section: Discussionmentioning

confidence: 99%

“…47,48 Cytogenetic analysis detected chromosomal abnormalities in 5/6 cases (83%), similar to 90% of all cases of newly diagnosed myeloma. 46 Two patients had a complex karyotype at presentation, including one with three high-risk abnormalities (translocation t(4;14), gain of the 1q21 region and deletion 17p) -findings that are associated with unfavorable outcome and shorter median survival -whereas two patients had evidence of trisomies of odd-numbered chromosomes (hyperdiploidy) that are typically associated with better survival. 49,50 This distribution of genetic abnormalities is similar to the reported literature and does not indicate a unique subtype of plasma cell myeloma.…”

Section: Discussionmentioning

confidence: 99%

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IgG4 plasma cell myeloma: new insights into the pathogenesis of IgG4-related disease

et al. 2014

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IgG4-related disease is a newly described systemic fibroinflammatory process, characterized by increase in IgG4-positive plasma cells. Its pathogenesis, including the role of IgG4, remains poorly understood. Plasma cell myeloma is typically associated with a large monoclonal serum spike, which is frequently of IgG isotype. We sought to identify and characterize a subset of IgG4-secreting myeloma, as it may provide a biological model of disease with high serum levels of IgG4. Six out of 158 bone marrow biopsies (4%) from patients with IgG myeloma expressed IgG4. Four patients were men and two were women, with a mean age of 64 (range 53-87) years. Imaging showed fullness of pancreatic head (1), small non-metabolic lymphadenopathy (1), and bone lytic lesions (6). Two patients developed necrotizing fasciitis. All had elevated serum M-protein (mean 2.4, range 0.5-4.2 g/dl), and none had definite signs or symptoms of IgG4-related disease. Four myelomas had plasmablastic morphology. Four had kappa and two had lambda light chain expression. Three cases expressed CD56. Two patients had a complex karyotype. In conclusion, the frequency of IgG4 myeloma correlates with the normal distribution of IgG4 isoform. The patients with IgG4 myeloma appear to have a high rate of plasmablastic morphology and could be predisposed to necrotizing fasciitis. Despite high serum levels of IgG4, none had evidence of IgG4-related disease. These findings suggest that the increased number of IgG4-positive plasma cells is not the primary etiologic agent in IgG4-related disease. Elevated serum levels of IgG4 is not sufficient to produce the typical disease presentation and should not be considered diagnostic of IgG4-related disease.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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IgG4 plasma cell myeloma: new insights into the pathogenesis of IgG4-related disease

et al. 2014

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“…The bone marrow is usually infiltrated heavily with plasma cells showing the same morphological features as those in the peripheral blood [19,20]. The cases of PCL [21].…”

Section: Discussionmentioning

confidence: 99%

Plasma Cell Leukemia: Case Series From a Tertiary Center with Review of Literature

Naseem

Kaur

Gupta

et al. 2011

Indian J Hematol Blood Transfus

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Plasma cell leukemia is an unusual manifestation of multiple myeloma, reported to occur in 2% of newly diagnosed patients. It may either present at the time of diagnosis (primary) or evolve as a late feature in the course of multiple myeloma (secondary). Most clinical signs of myeloma are observed in plasma cell leukemia, although osteolytic lesions and bone pain are less frequent and lymphadenopathy, organomegaly and renal failure are more often present. The immunophenotype of plasma cell leukemia differs typically from that of myeloma by lack of aberrant CD56 expression. An abnormal karyotype is more frequently found in plasma cell leukemia and there is higher incidence of unfavourable cytogenetics. Plasma cell leukemia is an aggressive disease, characterized by a fulminant course and a short survival. We are reporting cases of this rare condition which presented at our center over 3 years along with review of literature.

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“…[13][14][15][16][17] For immunohistochemical staining, 4-mm-thick paraffin-embedded tissue sections were subsequently dewaxed, rehydrated and subjected to antigen retrieval using EnVision FLEX target retrieval solution at pH 6 and heated at 95 1C. Slides were cooled and treated with EnVision FLEX/HRP Technique (Dako), counterstained with hematoxylin and mounted.…”

Section: Pathological Findingsmentioning

confidence: 99%

Hepatitis C virus-related lymphoproliferative disorders encompass a broader clinical and morphological spectrum than previously recognized: a clinicopathological study

et al. 2014

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We describe a retrospective series of B-cell lymphoproliferative disorders associated with hepatitis C virus infection. In addition to splenic marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma, all of which showed some specific features, we found two poorly described groups of cases. The first featured disseminated marginal zone lymphoma without splenic marginal zone lymphoma features, defying the current marginal zone lymphoma classification; the other consisted of monoclonal B lymphocytes in the peripheral blood, bone marrow or other tissues, with no clinical or histological evidence of lymphoma, and exhibiting a pattern that requires proper identification in order to avoid the misdiagnosis of the lymphoma. Diagnosis of hepatitis C virus infection-associated lymphoproliferative disorders requires the integration of clinical, pathological and molecular findings to establish an adequate diagnosis and decide the appropriate therapy to be applied.

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Plasma Cell Neoplasms

Cited by 58 publications

References 182 publications

IgG4 plasma cell myeloma: new insights into the pathogenesis of IgG4-related disease

IgG4 plasma cell myeloma: new insights into the pathogenesis of IgG4-related disease

Plasma Cell Leukemia: Case Series From a Tertiary Center with Review of Literature

Hepatitis C virus-related lymphoproliferative disorders encompass a broader clinical and morphological spectrum than previously recognized: a clinicopathological study

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