Plasma circulating miR-23~27~24 clusters correlate with the immunometabolic derangement and predict C-peptide loss in children with type 1 diabetes

Garavelli, S.; Bruzzaniti, Sara; Tagliabue, Elena; Silvestre, Dario Di; Prattichizzo, Francesco; Mozzillo, Enza; Fattorusso, Valentina; Sala, Lucia La; Ceriello, Antonio; Puca, Annibale Alessandro; Mauri, Pierluigi; Strollo, Rocky; Marigliano, Marco; Maffeis, Claudio; Petrelli, Alessandra; Bosi, Emanuele; Franzese, Adriana; Galgani, Mario; Matarese, Giuseppe; Candia, Paola de

doi:10.1007/s00125-020-05237-x

Cited by 29 publications

(45 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the high numbers of miRNAs and their involvement in virtually all biological processes, including immune regulation, multiple studies investigated their biomarker potential in the context of islet autoimmunity and T1D (42,56,66,(85)(86)(87)(88)(89)(90)(91). In contrast to the majority of disease symptoms, biomarkers enable the objectively quantifiable characterization of a disease and its progression.…”

Section: Mirnas As Biomarkers For Islet Autoimmunity and T1dmentioning

confidence: 99%

“…Similarly, levels of the miR23~27~24 cluster were increased during disease progression in children with T1D and correlated with osteoprotegerin abundance. Importantly, combining the levels of osteoprotegerin and the miR23~27~24 cluster in plasma of newly diagnosed T1D patients enabled the prediction of insulin secretion 12 months after diagnosis (86).…”

Section: Cell-free Circulating Mirnasmentioning

confidence: 99%

See 1 more Smart Citation

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

Scherm

Daniel

2020

Front. Endocrinol.

View full text Add to dashboard Cite

The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized. Consequently, aberrant miRNA expression contributes to the defective regulation of T cell development, differentiation, and function. This can result in immune activation and impaired tolerance mechanisms, which exert a cardinal function for the onset of islet autoimmunity and the progression to T1D. The specific impact of miRNAs for immune regulation and how miRNAs and their downstream targets are involved in the pathogenesis of islet autoimmunity and T1D has been investigated recently. These studies revealed that increased expression of individual miRNAs is involved in several layers of tolerance impairments, such as inefficient Treg induction and Treg instability. The targeted modulation of miRNAs using specific inhibitors, resulting in improved immune homeostasis, as well as improved methods for the targeting of miRNAs, suggest that miRNAs, especially in T cells, are a promising target for the reestablishment of immune tolerance.

show abstract

Section: Mirnas As Biomarkers For Islet Autoimmunity and T1dmentioning

confidence: 99%

Section: Cell-free Circulating Mirnasmentioning

confidence: 99%

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

Scherm

Daniel

2020

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…In addition, distinct circulating miRNA profiles between subjects with obesity and T2D aroused considerable attention given their potential as biomarkers for these diseases. Indeed, strong correlations were found between some circulating miR-NAs and the development of metabolic syndrome [59], obesity [60,61], diabetes [32,62,63] and/or linked to CVD [37,64]. Nowadays, miRNAs are attractive candidates as innovative biomarkers and have been proposed to promote the progression to diabetes [29,33,62].…”

Section: Mirnas and Cardiovascular Risk Factors (Crfs)mentioning

confidence: 99%

“…Indeed, strong correlations were found between some circulating miR-NAs and the development of metabolic syndrome [59], obesity [60,61], diabetes [32,62,63] and/or linked to CVD [37,64]. Nowadays, miRNAs are attractive candidates as innovative biomarkers and have been proposed to promote the progression to diabetes [29,33,62]. Furthermore, in bariatric metabolic surgery (BMS), miRs might be effective for making the decision about surgery and/or predicting weight loss after BMS [65], providing targets for future treatments.…”

Section: Mirnas and Cardiovascular Risk Factors (Crfs)mentioning

confidence: 99%

Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk

Sala

Crestani

Garavelli

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Metabolic disorders such as obesity and type 2 diabetes (T2D) are considered the major risk factors for the development of cardiovascular diseases (CVD). Although the pathological mechanisms underlying the mutual development of obesity and T2D are difficult to define, a better understanding of the molecular aspects is of utmost importance to identify novel therapeutic targets. Recently, a class of non-coding RNAs, called microRNAs (miRNAs), are emerging as key modulators of metabolic abnormalities. There is increasing evidence supporting the role of intra- and extracellular miRNAs as determinants of the crosstalk between adipose tissues, liver, skeletal muscle and other organs, triggering the paracrine communication among different tissues. miRNAs may be considered as risk factors for CVD due to their correlation with cardiovascular events, and in particular, may be related to the most prominent risk factors. In this review, we describe the associations observed between miRNAs expression levels and the most common cardiovascular risk factors. Furthermore, we sought to depict the molecular aspect of the interplay between obesity and diabetes, investigating the role of microRNAs in the interorgan crosstalk. Finally, we discussed the fascinating hypothesis of the loss of protective factors, such as antioxidant defense systems regulated by such miRNAs.

show abstract

“…For example, Dong et al [8] identified miR-182 as a new negative regulator of fat formation and a potential therapeutic target for obesity. In addition, Garavelli et al [9] reported that miR-24-3p is upregulated in the progression of type 1 diabetes. Many investigations reported that obesity is associated with a series of metabolic syndrome, of which diabetes is one of the main complications [10].…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of Circulating miR-24-3p in Children with Obesity and Its Predictive Value for Metabolic Syndrome

2021

View full text Add to dashboard Cite

Introduction: Obesity is a major risk factor for metabolic disorders in children. Therefore, it is particularly important to study the abnormal regulation of circulating miR-24-3p in obese children and its predictive value for metabolic syndrome. Methods: Serum samples were obtained from children with obesity (n = 45), obese children with metabolic syndrome (n = 52), and healthy controls (n = 50). The expression levels of miR-24-3p were detected by reverse transcription quantitative PCR. The ROC curve was used to evaluate the diagnostic value of miR-24-3p. Pearson’s correlation analysis was performed to evaluate the relationship between serum miR-24-3p and different clinical parameters. Logistic regression analysis was used to evaluate the relationship between miR-24-3p and obesity with metabolic syndrome in children. Results: The expression of miR-24-3p was the highest in obese children with metabolic syndrome. ROC results showed that miR-24-3p had the ability to distinguish healthy individuals from obese children (area under the curve [AUC] = 0.951) and can predict the occurrence of metabolic syndrome for obese children (AUC = 0.890). The expression level of miR-24-3p was positively correlated with body mass index (r = 0.817, p < 0.001), fasting blood glucose (r = 0.798, p < 0.001), triglycerides (r = 0.773, p < 0.001), systolic blood pressure (r = 0.746, p < 0.001), and diastolic blood pressure (r = 0.623, p < 0.001), respectively. Logistic regression analysis showed that miR-24-3p was an independent influence factor for the occurrence of metabolic syndrome in obese children. Discussion/Conclusion: MiR-24-3p is a potential noninvasive marker for children with obesity and has predictive value for the occurrence of metabolic syndrome.

show abstract

Plasma circulating miR-23~27~24 clusters correlate with the immunometabolic derangement and predict C-peptide loss in children with type 1 diabetes

Cited by 29 publications

References 62 publications

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes

Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk

Dysregulation of Circulating miR-24-3p in Children with Obesity and Its Predictive Value for Metabolic Syndrome

Contact Info

Product

Resources

About