Plasma concentration for optimal sedation and total body clearance of propofol in patients after esophagectomy

Abstract

The present study investigated plasma propofol concentration for optimal sedation and total body clearance in patients who required sedation for mechanical ventilation after esophagectomy. Seven patients after esophagectomy were enrolled in this study. Plasma propofol concentrations were measured with high performance liquid chromatography. Total body clearance was calculated from the steady-state concentration. The infusion rate of propofol for achieving the sedation score of level 3 (drowsy, responds to verbal stimulation) was 1.74 +/- 0.82 mg kg(-1) h(-1) (mean +/- SD, n = 7) when the plasma propofol concentration and the total body clearance were 0.85 +/- 0.24 microg ml(-1) and 1.83 +/- 0.54 l min(-1) (mean +/- SD, n =7), respectively.

Transdermal Iontophoretic Delivery of Propofol: A General Anaesthetic in the Form of its Phosphate Salt

“…The authors reported that the target plasma concentration of propofol required for achieving sedation score of level 3 is 0.85 ± 0.24 μg/mL. With the clearance value of propofol being 1.83 L/min, the required input rate for achieving the above‐mentioned plasma concentration was 1.74 mg/(kg h) 35. On the basis of these reports, the required target rate of input of PP (1.7 M concentration of PP is equal to 1 M of propofol) would be 2.98 mg/(kg h).…”

“…With the clearance value of propofol being 1.83 L/min, the required input rate for achieving the above-mentioned plasma concentration was 1.74 mg/(kg h). 35 On the basis of these reports, the required target rate of input of PP (1.7 M concentration of PP is equal to 1 M of propofol) would be 2.98 mg/(kg h). For the purpose of this project, if one considers pediatric patient of weight approximately 2 kg, then the average transdermal input rate (from the overall patch) to be achieved would be 5.96 mg/ h. If the proposed size of the delivery device is about 10 cm 2 , then the target flux to be achieved would be 596 :g/(h cm 2 ).…”

Propofol lipidic infusion promotes resistance to antifungals by reducing drug input into the fungal cell

“…We showed that propofol infusion also supported mould germination and growth, apart from yeasts. It is important to emphasize that the propofol concentrations used in all assays are within the plasma levels often achieved in clinical practice [ 11 , 12 ].…”

Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring

“…So far, the high performance liquid chromatography (HPLC) is the most commonly used analytical method for measuring the propofol concentrations in plasma4567891011, and it is also used as a reference to evaluate other methods1213. However, due to the complex matrix of plasma, the complicated sample pretreatment must be implemented before the HPLC separation process can be carried out.…”