Plasma Concentration of Big Endothelin-1 and Its Relation With Plasma NT-proBNP and Ventricular Function in Heart Failure Patients

Rivera, Miguel; Cortés, Raquel; Portolés, Manuel; Valero, Ricardo; Sancho‐Tello, María; Martínez‐Dolz, Luis; Sevilla, Begoña; Taléns‐Visconti, Raquel; Jordán, Alejandro; Miró, Vicente; Pérez-Boscá, José Leandro; Marı́n, Francisco; Climent, Vicente; Burgos, Fernando Garcı́a de; Payá, Rafael; Sogorb, Francisco; Bertoméu, Vicente; Salvador, Antonio

doi:10.1016/s1885-5857(06)60489-1

Cited by 5 publications

(10 citation statements)

References 40 publications

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“…On the one hand, the present results are in keeping with previous reports [14,15] showing that ET-1 levels were increased in PH patients, which may contribute to the synthesis and release of these peptides in cardiac tissues [23,24]. The positive correlation between ET-1 and N-BNP has been demonstrated [25]. We confirmed this correlation in IPAH patients.…”

Section: Discussionsupporting

confidence: 93%

Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension

Yang¹,

Liu²,

Yang³

2013

Cardiology

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Objectives: To investigate ghrelin levels in patients with idiopathic pulmonary arterial hypertension (IPAH) and the association of ghrelin with N-terminal brain natriuretic peptide (N-BNP), endothelin-1 (ET-1) and nitric oxide (NO). Methods: Plasma ghrelin, N-BNP, ET-1 and NO were measured, and echocardiography was performed in 20 IPAH patients and in 20 control subjects matched for age, sex and body mass index. Results: Plasma ghrelin and NT-proBNP levels were significantly higher in IPAH patients compared with values in control subjects (p < 0.05). In IPAH patients, ghrelin levels correlated positively with N-BNP (r = 0.616, p = 0.004), NO (r = 0.464, p = 0.039), right ventricle diameter (RVD; r = 0.485, p = 0.030) and pulmonary arterial systolic pressure (PASP; r = 0.591, p = 0.006). N-BNP levels correlated positively with RVD (r = 0.551, p = 0.012) and ET-1 (r = 0.451, p = 0.046). Conclusions: Plasma ghrelin levels were elevated in IPAH. Increased ghrelin levels correlated positively with N-BNP, PASP, RVD and NO, and N-BNP levels correlated positively with RVD and ET-1. Pulmonary vascular pathology is a complex imbalance of opposing forces. Ghrelin may not only provide a novel prognostic biomarker for IPAH but also be a potential new therapeutic strategy.

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Section: Discussionsupporting

confidence: 93%

Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension

Yang¹,

Liu²,

Yang³

2013

Cardiology

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“…Increased big ET-1 concentrations are associated with increased ventricular dysfunction [48]. In patients with acute myocardial infarction, ET-1 showed a significant positive correlation with BNP (r = 0.48, P < .0001) [49].…”

Section: Discussionmentioning

confidence: 90%

“…The final effect in terms of muscular tonus of capillary vessels is the result of many different factors, which often oppose one another. Although the mechanism of their interactions is not completely clear, ET-1 is an essential regulator of muscular tonus of capillary vessels and should not be treated simply as a marker of severe sepsis [48,49].…”

Section: Discussionmentioning

confidence: 99%

Plasma Endothelin-1 Levels in Septic Patients

Piechota

Banach

Irzmański

et al. 2007

J Intensive Care Med

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Dysfunction of the vascular endothelium (ET) causes an increase in serum ET-1 concentration, as observed in septic patients. It was assumed that in this patient population the ET-1 level correlates with the degree of sepsis severity, including the level of organ dysfunction and, in particular, the level of circulatory dysfunction. The aim of the present study was to assess the relationship between levels of ET-1 and levels of N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT), and C-reactive protein (CRP), as well as the Sepsis-related Organ Failure Assessment (SOFA) score in septic patients. PCT and CRP were used to estimate the level of sepsis severity; the SOFA score was used to estimate multiorgan dysfunction; and NT-proBNP was used as a marker of cardiac dysfunction. Twenty patients with sepsis and severe sepsis were included in the study. Blood serum ET-1, NT-proBNP, PCT, and CRP concentrations were determined at specific time intervals, and the SOFA score was calculated. Mean ET-1, NT-proBNP, PCT, and CRP concentrations were 8.39 pg/ml +/- 6.39 pg/mL, 140.80 pg/mL +/- 84.65 pg/mL, 22.32 ng/mL +/- 97.41 ng/mL, and 128.51 mg/L +/- 79.05 mg/L, respectively. Correlation between ET-1 levels and levels of NT-proBNP, PCT, and CRP was .3879 (P < .001), .358 (P < .001), and .225 (P = .011), respectively. Mean SOFA score was 6.31 pts +/- 3.75 pts. Correlation between the ET-1 levels and SOFA score was .470 (P < .001). Six patients (30%) died during the observation period of 28 days. ET-1 levels correlate with levels of NT-proBNP, PCT, and CRP, as well as the SOFA score in septic patients.

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Section: Discussionmentioning

confidence: 99%

“…Big ET-1 is more stable than ET-1 as it has a longer halflife and it is cleared slowly from the circulation [36,41]. Thus, big ET-1 is considered to be a sensitive measure of endothelin system activation [41]. Given that the high circulating level of ET-1 is mainly attributed to the release of big ET-1 [36,41], we measured big ET-1 in our breast cancer patients with relative LVH and healthy control women.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling

et al. 2020

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Background: The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an increased risk of cardiovascular complications following chemotherapy. While this increased risk of later occurring structural cardiac remodeling and/or dysfunction has largely been attributed to the cardiotoxic effects of breast cancer therapies, the effect of the breast tumor itself on the heart prior to cancer treatment has been largely overlooked. Thus, the objectives of this study were to assess the cardiac phenotype in breast cancer patients prior to cancer chemotherapy and to determine the effects of human breast cancer cells on cardiomyocytes. Methods: We investigated left ventricular (LV) function and structure using cardiac magnetic resonance imaging in women with breast cancer prior to systemic therapy and a control cohort of women with comparable baseline factors. In addition, we explored how breast cancer cells communicate with the cardiomyocytes using cultured human cardiac and breast cancer cells. Results: Our results indicate that even prior to full cancer treatment, breast cancer patients already exhibit relative LV hypertrophy (LVH). We further demonstrate that breast cancer cells likely contribute to cardiomyocyte hypertrophy through the secretion of soluble factors and that at least one of these factors is endothelin-1. Conclusion: Overall, the findings of this study suggest that breast cancer cells play a greater role in inducing structural cardiac remodeling than previously appreciated and that tumor-derived endothelin-1 may play a pivotal role in this process.

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Plasma Concentration of Big Endothelin-1 and Its Relation With Plasma NT-proBNP and Ventricular Function in Heart Failure Patients

Cited by 5 publications

References 40 publications

Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension

Ghrelin and Its Relation with N-Terminal Brain Natriuretic Peptide, Endothelin-1 and Nitric Oxide in Patients with Idiopathic Pulmonary Hypertension

Plasma Endothelin-1 Levels in Septic Patients

Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling

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