Plasma Copeptin, Kidney Outcomes, Ischemic Heart Disease, and All-Cause Mortality in People With Long-standing Type 1 Diabetes

Velho, Gilberto; Boustany, Ray El; Lefèvre, Guillaume; Mohammedi, Kamel; Fumeron, Frédéric; Potier, Louis; Bankir, Lise; Bouby, Nadine; Hadjadj, Samy; Marre, Michel; Roussel, Ronan

doi:10.2337/dc16-1003

Cited by 57 publications

(55 citation statements)

References 41 publications

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“…Furthermore, higher copeptin concentrations conferred greater odds of impaired GFR, independent of other important risk factors. These findings from a cohort of people with T1D across the US are consistent with our observations in CACTI (3), and from GENEDIAB and GENESIS (7). …”

Section: Discussionsupporting

confidence: 90%

Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

Bjornstad

Johnson

Snell‐Bergeon

et al. 2017

Journal of Diabetes and its Complications

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Section: Discussionsupporting

confidence: 90%

Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

Bjornstad

Johnson

Snell‐Bergeon

et al. 2017

Journal of Diabetes and its Complications

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“…Cross-sectional and prospective studies in the general population have shown associations between plasma copeptin and albuminuria or renal function decline (Meijer et al, 2010;Enhorning et al, 2013;Roussel et al, 2015). High circulating copeptin concentration was also associated with the development and progression of diabetic nephropathy in patients with type 2 diabetes (Boertien et al, 2013;Velho et al, 2013;Hu et al, 2015;Pikkemaat et al, 2015;Zhu et al, 2016), and with prevalence of ESRD in subjects with long-standing type 1 diabetes (Bjornstad et al, 2016;Velho et al, 2016). Experimental data suggests a causal role of vasopressin in renal dysfunction through activation of the V2-receptor (V2R).…”

Section: Introductionmentioning

confidence: 98%

Antagonism of vasopressin V2 receptor improves albuminuria at the early stage of diabetic nephropathy in a mouse model of type 2 diabetes

Boustany

Taveau

Chollet

et al. 2017

Journal of Diabetes and its Complications

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Methods: Male obese diabetic db/db mice were treated for 12 weeks with a selective V2R antagonist (SR121463) and compared to non-treated db/db and non-diabetic db/m mice. All animals were previously uninephrectomized.Results: The V2R antagonist did not alter glycaemia or glycosuria in db/db mice. It induced a two-fold increase in urine output and a 52% decrease in urine osmolality compared to nontreated db/db mice. After four weeks of treatment urinary albumin to creatinine ratio was 50% lower in treated mice compared to non-treated mice, and remained significantly lower until end of experiment. Glomerular filtration rate increased significantly over time in non-treated db/db mice but remained stable in treated mice.Conclusions: This study shows that vasopressin contributes to albuminuria and glomerular hyperfiltration via V2R in a mouse model of type 2 diabetes. It documents causality behind the association of vasopressin with renal disease observed in diabetic patients.

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“…We (NB, GV) observed median plasma levels of both peptides ~60% higher in men than in women in a French population‐based cohort . We have also observed higher copeptin levels in men in cohorts of patients with type 1 or with type 2 diabetes . The physiological basis of this sex‐related difference and its impact on vasopressin physiological and pathophysiological effects are unclear.…”

Section: High Vasopressin Level Is a Risk Factor For Glucose Metabolimentioning

confidence: 81%

Vasopressin and metabolic disorders: translation from experimental models to clinical use

Nakamura

Bouby

2017

J Intern Med

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Vasopressin has many physiological actions in addition to its well-defined role in the control of fluid homeostasis and urine concentration. An increasing body of evidence suggests that the vasopressin-hydration axis plays a role in glucose homeostasis. This review summarizes the knowledge accumulated over the last decades about the influence of vasopressin in the short-term regulation of glycaemia. It describes the possible role of this hormone through activation of V1a and V1b receptors on liver and pancreas functions and on the hypothalamic-pituitary-adrenal axis.Moreover, we report recent in vivo studies demonstrating the role of vasopressin in the long-term regulation of glycaemia. Indeed, V1a-or doubleV1aV1b-receptor knockout mice display significant changes in the glucose and lipid metabolism. In rats, sustained high V1aR activation increases basal glycaemia and aggravates glucose intolerance in obese rats. Finally, the translation from animal findings to human was evidenced by epidemiological and genetic studies that showed that high vasopressin level is a risk factor for hyperglycaemia, metabolic disorders and diabetes.

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Plasma Copeptin, Kidney Outcomes, Ischemic Heart Disease, and All-Cause Mortality in People With Long-standing Type 1 Diabetes

Cited by 57 publications

References 41 publications

Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

Antagonism of vasopressin V2 receptor improves albuminuria at the early stage of diabetic nephropathy in a mouse model of type 2 diabetes

Vasopressin and metabolic disorders: translation from experimental models to clinical use

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