Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease

Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke

“…(14). A study by Satoh et al (16), support the idea that cyclophilin A levels increases during inflammatory processes. One study involving patients with coronary artery disease had significantly higher cyclophilin A levels in patients with stenosis than in those without (16).…”

“…A study by Satoh et al (16), support the idea that cyclophilin A levels increases during inflammatory processes. One study involving patients with coronary artery disease had significantly higher cyclophilin A levels in patients with stenosis than in those without (16). Yan et al (17) investigated the prognostic value of cyclophilin A in patients with coronary syndrome and reported significantly higher levels of cyclophilin A in patients with acute myocardial infarction and unstable angina pectoris than in patients with stable angina pectoris and healthy subjects.…”

The Expression of Cyclophilin A in Ovarian Endometrioma: Its Correlation with Recurrence and Vascularity

“…Many of the previous reports have shown that the expression and/or circulating levels of CyPA are higher in the presence of disorders related to inflammatory conditions (Billich et al 1997;Yang et al 2007;Li et al 2008;Nigro et al 2011;Stemmy et al 2011;Satoh et al 2013;Ramachandran et al 2014). For example, Satoh et al (2013) reported that CyPA expression is significantly higher in the atherosclerotic plaque of arterial walls in patients with atherosclerosis. Additionally, Stemmy et al (2011) revealed a higher concentrations of extracellular CyPA in the chronic phase of asthma using a murine model.…”

“…In light of these reports, our findings indicate that overexpression of CyPA in the endometriotic cells may reflect a response to oxidative stress. However, previous studies have shown that under inflammatory conditions, secreted CyPA acts as an autocrine and paracrine factor that exacerbates oxidative stress and inflammation (Satoh et al 2013). It is known that endometriosis causes a local inflammatory response (Yamaguchi et al 2008).…”

“…It is known as an inflammatory mediator that is secreted from various types of cells in response to inflammatory stimuli such as hypoxia, oxidative stres, and infection. Previous reports have shown that the expression and/or circulating levels of CyPA are higher in the presence of several disorders such as diabetes mellitus, asthma, rheumatoid arthritis, cardiovascular disease, and cancer, which causes inflammatory conditions in the body (Billich et al 1997;Yang et al 2007;Li et al 2008;Nigro et al 2011;Stemmy et al 2011;Satoh et al 2013;Ramachandran et al 2014). During the inflammation process, the increased secretion of CyPA stimulates the production of cytokines as well as the migration of inflammatory cells, including monocytes/macrophages and neutrophils (Yang et al 2008;Tian-tian et al 2013).…”