Plasma D-Dimer as a Marker of Urinary Tract Infection in Children

Esteghamati, Maryam; Ghasemi, Kambiz; Javaheri, Zohreh; Zoghi, Ghazal

doi:10.5812/numonthly.117054

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…It's possible that this will aid in both the detection and treatment of urinary tract infections, as well as the avoidance of consequences that can arise from going untreated. In order to ensure prompt diagnosis, treatment, and prevention of future complications associated with UTI, the data may be useful in defining a departmental protocol for doing urine analysis in all children presenting with fever without any focus of infection [9]. Sample size: In total, 278 patients were used for the research.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Urinary Tract Infection in Febrile Children without Any Focus on Infection

Jogezai¹,

Zahra²,

Fatima³

2022

PJMHS

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Background: In newborns and young children, a urinary tract infection is a frequent hidden cause of fever. Children younger than a year old who appear with fever and symptoms of UTI are usually given treatment for something else. Objectives: The objective of this study was to assess the prevalence of UTI in children presenting to a tertiary care hospital between the ages of 1 month and 36 months with nonspecific fever. Duration and study settings: The Children's Hospital Pakistan Institute of Medical Science, SZABMU, Islamabad, was the site of this trial, which ran from Jan 2018 to June 2018. Study design: Descriptive cross sectional Methodology: After a complete medical history and physical examination, a urine sample was taken for testing and culture using a soft tube in younger children and a clean catch approach in older children or those who are cooperative. Urisys 2400 was used to analyse the urine samples. Larger children's urine samples were grown on CLED agar plates (cysteine lactose, electrolyte deficient). Clinitek Siemens, a haematology analyser, was used to determine the number of white blood cells in the blood. The Pakistan Institute of Medical Sciences in Islamabad is home to a state-of-the-art laboratory where tests including leucocyte count, urine DR, and culture were conducted. A pre-designed proforma was used to record the patient's demographic information, medical history, diagnosis, and laboratory results. Results: In this study, 6.47 percent (n=18) of 278 children aged 1 to 36 who presented to a tertiary care hospital with a fever and no other obvious signs of infection were found to have a urinary tract infection. Conclusion: Children arriving to a tertiary care hospital with a fever and no other signs of infection are not likely to have a urinary tract infection. Keywords: UTI in children with diffuse fever and no obvious source of infection.

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Section: Introductionmentioning

confidence: 99%

Frequency of Urinary Tract Infection in Febrile Children without Any Focus on Infection

Jogezai¹,

Zahra²,

Fatima³

2022

PJMHS

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Dímero D en enfermedades infecciosas no asociadas a COVID-19

Rivera Andrade

2024

Rev. Cun.

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OBJETIVO: Describir la elevación de dímero D con enfermedades infecciosas no asociadas a COVID-19. MÉTODO: Estudio descriptivo retrospectivo de 54 pacientes ingresados en el Departamento de Pediatría del Hospital Regional de Zacapa meses de marzo 2,020 a febrero del 2,024. RESULTADOS: : La enfermedad con mayor frecuencia y elevación de dímero D fue neumonías asociadas a la comunidad (30%), el grupo etario más afectado fue la edad neonatal (31%), el género con mayor frecuencia fue femenino (56%), se pudo determinar que el rango presente en los expedientes clínicos con elevación de dímero D fueron valores negativos de 0 a 500 ng/mL (35%), 2000 a 5000 ng/mL (24%) y ≥ 5000 ng/mL (17%), hubieron 8 casos de defunción en total de 54 expedientes, que representó de mortalidad de 15% y una estancia hospitalaria ≥ 10 días en el 61%. CONCLUSIÓN: Respecto al estudio se pudo observar elevación de dímero D en los pacientes con enfermedades infecciosas no asociadas a COVID-19 ya que un 65% presentaba valores elevados comparado con el 35% que se mantuvo negativo.

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Predictive Value of D-dimer in Children with Acute Pyelonephritis

Sadr Moharerpour,

Mohajerzadeh,

Nickavar

et al. 2024

Arch Pediatr Infect Dis

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Background: The diagnosis of acute febrile urinary tract infection (UTI) relies on various clinical and laboratory findings, which have shown conflicting results. Objectives: This study aimed to evaluate the utility of serum D-dimer in distinguishing acute pyelonephritis (APN) from other acute bacterial febrile infections. Methods: This cross-sectional study included 47 children with a confirmed UTI (verified by positive urine culture) and 47 children with other bacterial febrile infections. Serum D-dimer levels were measured in all patients before starting antibacterial treatment. Results: A total of 94 febrile children were evaluated, with females outnumbering males. Significant differences between the two groups were observed for microscopic hematuria (P = 0.044), bacteriuria (P ˂ 0.001), white blood cell (WBC) count (P = 0.047), and hemoglobin (Hgb) (P = 0.035), but not for serum D-dimer (P = 0.327). Binary logistic regression analysis revealed that Hgb (P = 0.019) had a significant predictive value in APN, whereas serum D-dimer did not. Serum D-dimer was found to be an unreliable biomarker for distinguishing febrile UTI from other bacterial febrile infections. Conclusions: Based on our findings, while D-dimer levels increase in various acute bacterial febrile infections, they are not effective in differentiating febrile UTI from other bacterial infections.

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Plasma D-Dimer as a Marker of Urinary Tract Infection in Children

Cited by 3 publications

References 18 publications

Frequency of Urinary Tract Infection in Febrile Children without Any Focus on Infection

Frequency of Urinary Tract Infection in Febrile Children without Any Focus on Infection

Dímero D en enfermedades infecciosas no asociadas a COVID-19

Predictive Value of D-dimer in Children with Acute Pyelonephritis

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