Plasma Diamine Oxidase Activity Is a Useful Biomarker for Evaluating Gastrointestinal Tract Toxicities during Chemotherapy with Oral Fluorouracil Anti-Cancer Drugs in Patients with Gastric Cancer

Namikawa, Tsutomu; Fukudome, Ian; Kitagawa, Hiroyuki; Okabayashi, Takehiro; Kobayashi, Mariko; Hanazaki, Kazuhiro

doi:10.1159/000336799

Cited by 24 publications

(20 citation statements)

References 31 publications

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“…Reduced DAO activity in the intestine and kidney, and increased D-lactate level in serum are shown to correlate with the extent of histologic injury [41], [42]. Thus, in addition to microscopic lesions in intestine, the D-lactate concentration in serum, and DAO activity in serum and tissue were also detected to assess the effects of DON exposure on intestinal barrier function.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol

Xiao

Ren

et al. 2014

PLoS ONE

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The mycotoxin deoxynivalenol (DON), one of the most common food contaminants, primarily targets the gastrointestinal tract to affect animal and human health. This study was conducted to examine the protective function of glutamic acid on intestinal injury and oxidative stress caused by DON in piglets. Twenty-eight piglets were assigned randomly into 4 dietary treatments (7 pigs/treatment): 1) uncontaminated control diet (NC), 2) NC+DON at 4 mg/kg (DON), 3) NC+2% glutamic acid (GLU), and 4) NC+2% glutamic acid + DON at 4 mg/kg (DG). At day 15, 30 and 37, blood samples were collected to determine serum concentrations of CAT (catalase), T-AOC (total antioxidant capacity), H2O2 (hydrogen peroxide), NO (nitric oxide), MDA (maleic dialdehyde), DAO (diamine oxidase) and D-lactate. Intestinal morphology, and the activation of Akt/mTOR/4EBP1 signal pathway, as well as the concentrations of H2O2, MDA, and DAO in kidney, liver and small intestine, were analyzed at day 37. Results showed that DON significantly (P<0.05) induced oxidative stress in piglets, while this stress was remarkably reduced with glutamic acid supplementation according to the change of oxidative parameters in blood and tissues. Meanwhile, DON caused obvious intestinal injury from microscopic observations and permeability indicators, which was alleviated by glutamic acid supplementation. Moreover, the inhibition of DON on Akt/mTOR/4EBP1 signal pathway was reduced by glutamic acid supplementation. Collectively, these data suggest that glutamic acid may be a useful nutritional regulator for DON-induced damage manifested as oxidative stress, intestinal injury and signaling inhibition.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol

Xiao

Ren

et al. 2014

PLoS ONE

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“…In the present study, proline supplementation could increase D-xylose concentration indicating that proline could have a positive effect on the gastrointestinal tract digestibility. The activity of the DAO is so high in the intestinal mucosa, that plasma DAO activity may be useful for monitoring and evaluating gastrointestinal tract injury (Namikawa et al, 2012). In the present study, 0.5% proline supplementation decreased DAO concentrations, however, it could increase DAO concentrations after LPS challenge, which suggested that proline has a positive effect on maintenance of the mucosal barrier after LPS challenge.…”

Section: Discussionmentioning

confidence: 99%

Effects of L-proline on the Growth Performance, and Blood Parameters in Weaned Lipopolysaccharide (LPS)-challenged Pigs

Kang¹,

Zhang²,

Hou³

et al. 2014

Asian Australas. J. Anim. Sci

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This trail was conducted to study the effect of L-proline on the growth performance, and blood parameter in the weaned lipopolysaccharide (LPS)-challenged pigs. Thirty six pigs (9.13±0.85 kg) were assigned randomly to dietary treatments in a 2×3 factorial arrangement in a 20-d growth assay. Factors were intraperitoneal injection with saline or LPS, and three dietary L-proline supplement levels (0%, 0.5%, or 1.0%). On d 10, blood samples were collected at 3 h after LPS (100 μg LPS/kg body weight [BW]) or saline injection. On d 20 of the trial, all pigs were orally administrated D-xylose (0.1 g/kg BW) at 2 h, and blood samples were collected at 3 h after LPS or saline injection. As a result, dietary supplementation with 0.5% proline had a tendency to increase average daily gain (ADG) in piglets during d 10 to 20 (p = 0.088). Without LPS challenge, dietary supplementation with 1.0% proline had no effect on growth hormone (GH) concentrations on d 10 (p>0.05), but decreased it after LPS challenge (p<0.05). There was LPS challenge×proline interaction for GH concentrations on d 10 (p<0.05). Dietary supplementation with 1.0% proline decreased glucagon concentration on d 10 after LPS challenge (p<0.05). In addition, dietary supplementation with proline increased superoxide dismutase (SOD) activity significantly on d 10 and 20 (p<0.05), and 1.0% proline increased heat shock proteins-70 concentration on d 10 (p<0.05). Moreover, proline supplementation increased diamine oxidase (DAO) concentrations after LPS challenge (p<0.05). There was LPS challenge×proline interaction for DAO (p<0.05). Furthermore, dietary supplementation with 1.0% proline increased the D-xylose level when no LPS challenge (p<0.05). These results indicate that proline supplementation could improve growth performance, increase SOD activities, and has a positive effect on the gastrointestinal tract digestibility in early weaned pigs.

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“…The present data indicated that Trichinella spiralis infection increased intestinal permeability evidenced by the reduced DAO and increased LPS concentrations. Serum DAO activity and LPS concentration are associated with the maturation and integrity of small intestinal mucosa Namikawa et al 2012). Previous reports revealed that the increased permeability partially corresponded to downregulated tight junction (Ruan et al 2014).…”

Section: Discussionmentioning

confidence: 97%

Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways

et al. 2015

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This study aimed to investigate the protective effects of preinduction of heat shock protein 70 (HSP70) on Trichinella spiralis infection-induced post-infectious irritable bowel syndrome (PI-IBS) in mice. Trichinella spiralis infection significantly reduced HSP70 abundance, ileal villus height and crypt depth, expression of tight junctions, serum lysine and arginine concentrations, and ileal SCL7A6 and SCL7A7 mRNA levels, induced inflammatory response, and activated NF-κB signaling pathway. Meanwhile, the heat treatment upregulated HSP70 expression, and then reversed intestinal dysfunction and inflammatory response. Preinduction of HSP70 enhanced serum arginine and intestinal SCL7A7 expression and inhibited NF-κB activation compared with PI-IBS model. Treatment with pyrrolidine dithiocarbamate (PDTC, an NF-κB inhibitor) and N-nitro-L-arginine methyl ester hydrochloride (L-NAME, a nitric oxide synthase inhibitor, NOS) further demonstrated that preinduction of HSP70 might inhibit NF-κB and activated NOS/nitric oxide (NO) signaling pathways. In conclusion, preinduction of HSP70 by heat treatment may confer beneficial effects on Trichinella spiralis infection-induced PI-IBS in mice, and the protective effect of HSP70 may be associated with inhibition of NF-κB and stimulation of NOS/NO signaling pathways.

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Plasma Diamine Oxidase Activity Is a Useful Biomarker for Evaluating Gastrointestinal Tract Toxicities during Chemotherapy with Oral Fluorouracil Anti-Cancer Drugs in Patients with Gastric Cancer

Cited by 24 publications

References 31 publications

Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol

Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol

Effects of L-proline on the Growth Performance, and Blood Parameters in Weaned Lipopolysaccharide (LPS)-challenged Pigs

Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways

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