Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction
Hannah Zimmerman‐Federle,
Greta Ren,
Sarah Dowling
et al.
Abstract:Drug overdoses have risen dramatically in recent years. We developed a simple nontargeted method using a disposable paper spray cartridge with an integrated solid phase extraction column. This method was used to screen for ~160 fentanyl analogs, synthetic cannabinoids, other synthetic drugs, and traditional drugs of abuse in over 300 authentic overdose samples collected at emergency departments in Indianapolis. A solid phase extraction step was implemented on the paper spray cartridge to enable subnanograms pe… Show more
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