Plasma Endocan Levels in Patients With Isolated Coronary Artery Ectasia

Turhan, Turan; Akyüz, Ali Rıza; Aykan, Ahmet Çağrı; Kul, Selim; Çırakoğlu, Ömer Faruk; Aslan, Ahmet Oguz; Gül, İlker; Ucar, Utku; Demir, Selim; Çelık, Şükrü

doi:10.1177/0003319716637789

Cited by 21 publications

(24 citation statements)

References 31 publications

(48 reference statements)

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“…Other biomarker levels were within the normal range as in the control group of our study. Endothelial dysfunction, indicated by molecules such as endocan and nitric oxide, has been linked to isolated CAE in previous studies (10,11). In our study, low levels of adropin and high levels of MPV were found to be independent risk factors for isolated CAE.…”

Section: Discussionsupporting

confidence: 66%

“…Histopathological results are similar in patients with atherosclerosis of the coronary arteries and those with isolated CAE (21). In a study by Malviya et al (18), Type 4 ectasia was the most common type, while Turan et al (10) determined that Type 2 was most common. We also observed that Type 2 was the most common type in our study.…”

Section: Discussionmentioning

confidence: 85%

“…Although the relationship between CAE and various molecules known to be associated with endothelial dysfunction has been demonstrated previously (10,11), there is no study in the literature examining the relationship between the serum adropin level and isolated CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE.…”

Section: Introductionmentioning

confidence: 99%

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Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

et al. 2019

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Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE. Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients. Results: Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011). Conclusion: Our results show that there is an association between low serum adropin level and isolated CAE.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

et al. 2019

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“…On the other hand, two recent studies found significantly lower mortality rates in CAE patients. In the first study, the cardiovascular mortality rate was 2% after a mean follow-up of 49 ± 21 months in 258 patients with CAE [14]. The second study, which included 540 patients with CAE, reported 2.22% mortality after 36 months of follow-up [15].…”

Section: Discussionmentioning

confidence: 99%

Association of serglycin levels with isolated coronary artery ectasia

et al. 2017

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A b s t r a c tBackground: Serglycin plays an important role in the inflammatory status, but the relationship between coronary artery ectasia (CAE) and serglycin is still unknown. Aim:In this study, we aimed to investigate the association of serglycin level with isolated CAE. Methods:Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. The Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured. Results:Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were independently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction of isolated CAE was 13.5, with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification. Conclusions:Serglycin levels are significantly and independently higher in patients with CAE.

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“…Our study 2 was designed as a pilot study, with some inevitable confounding factors. Therefore, further larger studies are needed to detect a causal relation between endocan and isolated CAE.…”

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confidence: 99%

Reply to “C-Reactive Protein Is the Origin for Novel Biomarkers”

Turhan

Akyüz

2017

Angiology

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We thank Kucukseymen et al 1 for their interest in our article. 2 Although the etiology of coronary artery ectasia (CAE) is not well understood, atherosclerosis can be assumed as an important component of the process. 3 Also, inflammation is a crucial stage in the atherosclerotic process. 4 Several studies have reported a relationship between CAE and systemic inflammation. 4,5 For example, Turhan et al 6 reported a link between C-reactive protein and CAE.The aim of our study 2 was to test the potential association of serum endocan level with CAE. We demonstrated that a higher endocan level reflects the presence and severity of isolated CAE. We certainly agree that inflammation may affect the endocan level independently. However, we 2 had mentioned in the Limitation section that our study population was small and its design did not allow us to discuss in detail the pathological mechanisms of increased endocan levels in this population. Furthermore, we excluded patients with inflammatory and infectious diseases, and the neutrophil-to-lymphocyte ratio, a simple index of systemic inflammatory response, 7 was similar in the 2 groups of our study.Our study 2 was designed as a pilot study, with some inevitable confounding factors. Therefore, further larger studies are needed to detect a causal relation between endocan and isolated CAE.

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Plasma Endocan Levels in Patients With Isolated Coronary Artery Ectasia

Cited by 21 publications

References 31 publications

Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Association of serglycin levels with isolated coronary artery ectasia

Reply to “C-Reactive Protein Is the Origin for Novel Biomarkers”

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