“…AGER, S100A9, CD14, IL1RAP, SPP1, and SerpinA1 mediate macrophage or neutrophil recruitment and activation, whether derived from inflammatory or parenchymal cells (28)(29)(30)(31)(32). Serum proteins that activate macrophages were present in the BALF, including albumin, AGT, SerpinF1, GSN, GC, HRG, and KNG1 (27,(33)(34)(35). RNA analysis of isolated alveolar epithelial cells from the Abca3-deleted mice indicated increased expression of RNAs associated with cell injury and induced inflammatory response, including IL-33.…”