Plasma gelsolin levels in patients with psoriatic arthritis: a possible novel marker

Esawy, Marwa M.; Makram, Wafaa K.; Albalat, Waleed; Shabana, Marwa A.

doi:10.1007/s10067-020-04959-y

Cited by 14 publications

(13 citation statements)

References 44 publications

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“…CRP is a well-known, widely used inflammatory marker. We found strong evidence that the CRP level in PsA patients was higher than in patients with Pso only [ 27 , 43 , 44 , 47 , 49 , 53 , 54 , 56 , 64 , 66 , 70 – 75 , 124 , 130 ]. We argue that the co-appearance of joint inflammation is responsible for this observation.…”

Section: Discussionmentioning

confidence: 88%

“…Four markers showed a strong level of evidence for a positive association with the presence of PsA in Pso: a higher level of matrix metalloproteinase 3 (MMP3) [ 49 , 51 , 52 , 54 ], a higher level of osteoprotegerin (OPG) [ 49 – 53 , 55 ], a higher level of interleukin 6 (IL-6) [ 61 – 64 ], and a higher level of C-reactive protein (CRP) [ 27 , 43 , 44 , 47 , 49 , 53 , 54 , 56 , 62 , 64 , 66 , 70 – 75 , 124 , 130 ].…”

Section: Resultsmentioning

confidence: 99%

“…Conflicting evidence was available for 14 of 137 laboratory markers: markers of bone metabolism (Dickkopf (DKK1) [ 52 , 53 ]; RANK-L [ 49 – 51 , 53 , 56 , 57 ]), markers of lipid metabolism (serum leptin [ 64 , 71 ]; total serum cholesterol [ 42 , 62 , 71 , 76 , 77 ]; total cholesterol: HDL ratio [ 42 , 76 ]; serum triglycerides [ 42 , 71 , 72 , 76 , 77 , 130 ]), inflammation markers (erythrocyte sedimentation rate (ESR) [ 43 , 44 , 47 , 56 , 62 , 66 , 70 , 74 , 75 ], cell numbers (platelet count [ 68 , 70 ]; white blood cell count [ 70 , 130 ]), cell phenotype (IL-17 secretion [ 58 , 59 ]), cytokine levels (IL-12/23 p40 [ 49 , 56 ]; macrophage colony-stimulating factor (M-CSF) [ 52 , 53 ]), uric acid [ 77 , 86 – 88 ], and antibodies against LL-37 [ 82 , 95 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding laboratory markers, there was strong evidence for the predictive value of (a change in) CXCL10 serum titers [ 27 , 60 ]. There was also strong evidence for the association with (but not prediction of) PsA of several markers related to bone metabolism [ 49 – 55 ] and inflammation [ 27 , 43 , 44 , 47 , 49 , 53 , 54 , 56 , 58 , 61 – 64 , 66 , 70 – 75 , 130 ]. With respect to genetic markers, we found no markers which reached a strong level of evidence for the association with PsA.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

et al. 2021

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Twenty to thirty percent of psoriasis (Pso) patients will develop psoriatic arthritis (PsA). Detection of Pso patients that are (at risk for) developing PsA is essential to prevent structural damage. We conducted a systematic search of five bibliographic databases, up to May 2020. We searched for studies assessing markers (clinical, laboratory, genetic) associated with the development or presence of PsA in Pso patients. Study selection and quality assessment of the included studies was performed, followed by a qualitative best evidence synthesis to determine the level of evidence for a marker and its association with concomitant/developing PsA in Pso. Overall, 259 possible markers were identified in 119 studies that met the inclusion criteria. Laboratory markers related to inflammation and bone metabolism reached a strong level of evidence for the association (not prediction) of PsA in Pso. Only CXCL10 showed strong evidence for a positive predictive value for PsA in Pso. The importance of timely detecting PsA in a Pso population, and finding more (bio)markers contributing to early detection, remains high.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

et al. 2021

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“…What is more, gelsolin regulates the actin assembly and disassembly in psoriatic arthritis (PsA). Thus, the expression of gelsolin reduces significantly in this kind of chronic inflammation [ 70 ]. Thymosin beta 4 (T β 4) is an actin-sequestering protein.…”

Section: Abps In Chronic Inflammatory Diseasesmentioning

confidence: 99%

Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

Zhang

et al. 2021

Analytical Cellular Pathology

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Actin-binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross-linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions. Consequently, these functions of ABPs help regulate cancer cell invasion and metastasis when cancer occurs. In recent years, a variety of ABPs have been found to be abnormally expressed in various cancers, indicating that the detection and interventions of unusual ABP expression to alter this are available for the treatment of cancer. The early stages of most cancer development involve long-term chronic inflammation or repeated stimulation. This is the case for breast cancer, gastric cancer, lung cancer, prostate cancer, liver cancer, esophageal cancer, pancreatic cancer, melanoma, and colorectal cancer. This article discusses the relationship between chronic inflammation and the above-mentioned cancers, emphatically introduces relevant research on the abnormal expression of ABPs in chronic inflammatory diseases, and reviews research on the expression of different ABPs in the above-mentioned cancers. Furthermore, there is a close relationship between ABP-induced inflammation and cancer. In simple terms, abnormal expression of ABPs contributes to the chronic inflammation developing into cancer. Finally, we provide our viewpoint regarding these unusual ABPs serving as potential biomarkers for chronic inflammation-induced cancer diagnosis and therapy, and interventions to reverse the abnormal expression of ABPs represent a potential approach to preventing or treating the corresponding cancers.

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DIA mass spectrometry characterizes urinary proteomics in neonatal and adult donkeys

Feng

Chen

Liu

et al. 2022

Sci Rep

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Health monitoring is critical for newborn animals due to their vulnerability to diseases. Urine can be not only a useful and non-invasive tool (free-catch samples) to reflect the physiological status of animals but also to help monitor the progression of diseases. Proteomics involves the study of the whole complement of proteins and peptides, including structure, quantities, functions, variations and interactions. In this study, urinary proteomics of neonatal donkeys were characterized and compared to the profiles of adult donkeys to provide a reference database for healthy neonatal donkeys. The urine samples were collected from male neonatal donkeys on their sixth to tenth days of life (group N) and male adult donkeys aging 4–6 years old (group A). Library-free data-independent acquisition (direct DIA) mass spectrometry-based proteomics were applied to analyze the urinary protein profiles. Total 2179 urinary proteins were identified, and 411 proteins were differentially expressed (P < 0.05) between the two groups. 104 proteins were exclusively expressed in group N including alpha fetoprotein (AFP), peptidase-mitochondrial processing data unit (PMPCB), and upper zone of growth plate and cartilage matrix associated (UCMA), which might be used to monitor the health status of neonatal donkeys. In functional analysis, some differentially expressed proteins were identified related to immune system pathways, which might provide more insight in the immature immunity of neonatal donkeys. To the best of our knowledge, this is the first time to report donkey urinary proteome and our results might provide reference for urinary biomarker discovery used to monitor and evaluate health status of neonatal donkeys.

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Plasma gelsolin levels in patients with psoriatic arthritis: a possible novel marker

Cited by 14 publications

References 44 publications

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review

Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

DIA mass spectrometry characterizes urinary proteomics in neonatal and adult donkeys

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