Plasma Ghrelin Concentrations in Different Clinical Stages of Diabetic Complications and Glycemic Control in Japanese Diabetics

Ueno, Hiroaki; Shiiya, Tomomi; Mizuta, Masanari; Mondal, Samim; Nakazato, Masamitsu

doi:10.1507/endocrj.k07-007

Cited by 36 publications

(31 citation statements)

References 37 publications

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“…The percentage inhibition of plasma DPP-4 activity 3 days after teneligliptin administration was 68.8 ± 23.8 %. Plasma ghrelin and des-acyl ghrelin levels at 30 to 180 min after the meal fell significantly from the baseline as described previously [19] in both before and after the teneligliptin treatment. Both plasma ghrelin and des-acyl ghrelin levels, as well as the AUCs for both compounds, were unaltered by teneligliptin treatment (Fig.…”

Section: Gastrointestinal Hormonessupporting

confidence: 81%

Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients

et al. 2015

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Section: Gastrointestinal Hormonessupporting

confidence: 81%

Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients

et al. 2015

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“…Plasma ghrelin levels increase upon fasting [3,5,6] and insulin-induced hypoglycemia [6], and decrease in response to oral or intravenous administration of glucose [5,7]. Plasma ghrelin level also exhibits a diurnal pattern with preprandial increases and postprandial decreases [5].…”

mentioning

confidence: 99%

“…Plasma ghrelin level also exhibits a diurnal pattern with preprandial increases and postprandial decreases [5]. Fasting plasma ghrelin level elevates in anorexia nervosa [8] and cachexia [9], and reduces in obesity [7,10].…”

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confidence: 99%

Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men

et al. 2011

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Ghrelin, a 28-amino-acid peptide with n-octanoylation indispensable for binding to the growth hormone secretagogue receptor (GHS-R), was originally discovered in the human and rat stomach [1]. Ghrelin molecules are present as two major endogenous forms, an acylated form (ghrelin) and a des-acylated form (desacyl ghrelin). Ghrelin stimulates growth hormone (GH) Abstract. Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and growth hormone (GH) secretion via interaction with the GH secretagogue receptor. Ghrelin molecules are present in two major endogenous forms, an acylated form (ghrelin) and a des-acylated form (des-acyl ghrelin). Recent studies indicated that aerobic exercise did not change plasma total ghrelin levels, however, dynamics of circulating ghrelin and des-acyl ghrelin during aerobic exercise remains unclear. The purpose of this study is to examine the effects of moderate intensity exercise on plasma ghrelin and des-acyl ghrelin concentrations, and to investigate the relationship between ghrelin molecules and other hormonal and metabolic parameters during exercise. Nine healthy males (25.2 ± 0.5 years) exercised for 60 min at 50% of their maximal oxygen consumptions. We measured the plasma concentrations of ghrelin, des-acyl ghrelin, GH, norepinephrine (NE), epinephrine (E), dopamine (DA), insulin, and glucose. Plasma ghrelin level significantly decreased during exercise, whereas plasma des-acyl ghrelin and total ghrelin levels did not change. Plasma NE, E, DA and GH levels were significantly increased during exercise. Plasma insulin level significantly decreased during exercise, and plasma glucose levels remained steady during exercise. NE, E, DA, and GH were correlated negatively with plasma ghrelin levels. These findings suggest that acute moderate exercise may suppress ghrelin release from the stomach, decrease ghrelin O-acyltransferase activity, and/or activate ghrelin utilization in peripheral tissues and that exercise-induced ghrelin suppression may be mediated by activated adrenergic system.

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“…Therefore, the stomach may play an important role in the regulation of appetite and food intake via neurohormonal links. Lately Ueno et al showed no significant postprandial decrease in total ghrelin levels at 30 and 60 min after meal was detected in diabetic patients with autonomic neuropathy which gave a definition of CV R-R [37]. However, the active form of ghrelin could be much more useful in determining its physiological and pathophysiological role than the total form.…”

Section: Discussionmentioning

confidence: 99%

No Ghrelin Response to Oral Glucose in Diabetes Mellitus with Gastroparesis

et al. 2009

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Abstract. To investigate the role of ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, in diabetic gastroparesis, we evaluated the plasma ghrelin profile during the oral glucose tolerance test in 55 patients with diabetes (men/women: 36/19, mean ± SE of age: 55.1 ± 1.7 years) with or without gastroparesis (diagnosed by the 13 Cacetate breath test). We also further examined cardiac autonomic neuropathy by assessing 24-hour variation of the R-R interval in randomly selected 32 patients with diabetes (men/women: 23/9, mean ± SE of age: 54.2 ± 2.5 years), and evaluated the influence of autonomic neuropathy on ghrelin. The fasting plasma ghrelin level was significantly lower in diabetes mellitus with gastroparesis than in healthy controls (7.9 ± 0.7 fmol/ml versus 16.6 ± 5.3 fmol/ml, p = 0.006). Patients with diabetes with gastroparesis showed no decrease of plasma ghrelin after glucose loading, unlike patients without gastroparesis or healthy controls. Diabetes mellitus with autonomic neuropathy, but not those without it, also showed no decrease of plasma ghrelin after glucose loading. Diabetic gastroparesis may be related to ghrelin-associated neurohormonal abnormalities, but the pathophysiological meaning of this abnormal ghrelin response needs further clarification.

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Plasma Ghrelin Concentrations in Different Clinical Stages of Diabetic Complications and Glycemic Control in Japanese Diabetics

Cited by 36 publications

References 37 publications

Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients

Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients

Significant lowering of plasma ghrelin but not des-acyl ghrelin in response to acute exercise in men

No Ghrelin Response to Oral Glucose in Diabetes Mellitus with Gastroparesis

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