Plasma Glucose, Creatinine and Urea Levels in Type 2 Diabetic Patients Attending A Nigerian Teaching Hospital

Idonije, Blessing O.; Festus, O.; Oluba, Olarewaju M.

doi:10.3923/rjmsci.2011.1.3

Cited by 29 publications

(21 citation statements)

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“…Diabetic patients with persistent hyperglycaemia can sustain permanent dysfunction of organs including kidneys, hearts, eyes, and nerves. Microalbumin has been positively correlated with higher glucose levels among patients with type 2 DM [24]. In accordance with this, a previous study has verified that there is a 49% morbidity rate of microalbuminuria among patients with different types of DM [25].…”

Section: Discussionsupporting

confidence: 54%

Protective Effects of the Segmental Renal Artery Clamping Technique on Ischemia-Reperfusion Injury in db/db Diabetic Mice

Liang

Zhu

Miao

et al. 2017

BioMed Research International

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Renal ischemia-reperfusion (I/R) injury is inevitable in partial nephrectomy and other kidney surgeries, with a higher incidence in patients with renal insufficiency. This study aimed to investigate the protective effects of precise segmental renal artery clamping (SRAC) against renal I/R injury in db/db diabetic mice, compared with conventional renal artery clamping (RAC). Grape seed extract, a powerful free radical scavenger, was administered to diabetic mice for 4 weeks before operation in subgroups (30 mg/kg/d). The unilateral renal pedicle was ligatured, and I/R injury to the contralateral kidney was induced (ischemia for 30 min followed by reperfusion for 24 h). Blood glucose value, creatinine, blood urea nitrogen, and urine microalbumin/urine creatinine ratio increased gradually and showed no preoperative statistical differences among six subgroups. These parameters were significantly lower in the SRAC than in the RAC group 24 h postoperatively. Moreover, the nonischemic area in the SRAC group expressed less KIM-1 and TNF-α mRNA and also revealed minor histopathological damage induced by I/R. These findings suggest that SRAC effectively reduces early renal injury induced by I/R and accelerates the recovery of renal function in diabetic mice. Thus, SRAC may be an ideal technique in partial nephrectomy, especially for patients with diabetic nephropathy and other renal insufficiencies.

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Section: Discussionsupporting

confidence: 54%

Protective Effects of the Segmental Renal Artery Clamping Technique on Ischemia-Reperfusion Injury in db/db Diabetic Mice

Liang

Zhu

Miao

et al. 2017

BioMed Research International

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“…Also, this work showed elevation in the level of serum creatinine and urea in the diabetic rats. Increased urea and creatinine indicates progressive renal damage and diabetic nephropathy [43]. Also, high production of urea may be a result of increased proteins catabolism in liver and plasma [44].…”

Section: Discussionmentioning

confidence: 99%

Effects of Grape Seed Proanthocyanidin Extract in Attenuating Diabetic Complications in Streptozotocin-Induced Diabetic Rats

Salahuddin¹,

Mohamed²

2017

J Appl Pharm

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Oxidative stress is a major cause for development and progression of diabetic mediated peripheral and central complications. The aim of this work is to evaluate the role of Grape Seed Proanthocyanidin (GSPE) extract in attenuating diabetic complications. Forty-five adult male Wistar rats were divided into three groups. Control, non-treated diabetic and diabetic rats treated with GSPE. Diabetes was induced by intraperitoneal injection of streptozotocin. After eight weeks; urine, blood and brain, heart, kidneys, liver tissue homogenate parameters were evaluated. The results showed a reduction in both renal and hepatic function in non-treated group as well as an elevated serum inflammatory markers (TNF-α, hs-CRP and IL-6). In addition, there were an elevation in both serum and different tissue homogenate oxidative stress parameters (SOD, GPx, Catalase and MDA). Treatments with GSPE improve the oxidative stress status in different tissue and improve renal and kidney functions. These finding suggested that GSPE is effective as adjuvant therapy for protection from diabetic complications as well as its potent antioxidant and anti-inflammatory activity.

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“…Increased levels of serum glucose, serum creatinine, urea, and uric acid are the markers of DN. [ 25 ] Recent studies have shown that coenzyme Q10 has a beneficial effect in decreasing the elevated HbA 1C , urea, and creatinine in alloxan-induced diabetic rats. [ 26 ] In the present study, co-administration of coenzyme Q10 and metformin has a significant reduction in elevated HbA 1C , urea, creatinine, and uric acid as compared to diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats

Maheshwari¹,

Balaraman²,

Sen³

et al. 2014

Indian J Pharmacol

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Objectives:This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with metformin on streptozotocin (STZ)-nicotinamide-induced diabetic nephropathy (DN).Materials and Methods:Type 2 diabetes in rats was induced with STZ-nicotinamide. The diabetic rats were treated with coenzyme Q10 (10 mg/kg, p.o.) alone or coenzyme Q10 + metformin. Various parameters of renal function tests such as serum creatinine, urea, uric acid, and markers of oxidative stress such as renal malondialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity, transforming growth factor-β (TGF-β), and nitrite content were estimated in renal tissues. All treated animal were subjected to histopathological changes of kidney.Result:Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum urea, serum creatinine, uric acid. In addition, STZ-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and glutathione (GSH) level. Moreover, TNF-α, MPO activity, TGF-β, and nitrite content were significantly increased in diabetic rats, while treatment with coenzyme Q10 or metformin or their combination ameliorate STZ-nicotinamide induced renal damage due to improvement in renal function, oxidative stress, suppression of TNF-α, MPO activity, TGF-β and nitrite content along with histopathological changes.Conclusions:This finding suggests that the treatment with coenzyme Q10 or metformin showed significant renoprotective effect against STZ-nicotinamide-induced DN. However, concomitant administration of both showed a better renoprotective effect than coenzyme Q10 or metformin alone treatment.

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Plasma Glucose, Creatinine and Urea Levels in Type 2 Diabetic Patients Attending A Nigerian Teaching Hospital

Cited by 29 publications

References 1 publication

Protective Effects of the Segmental Renal Artery Clamping Technique on Ischemia-Reperfusion Injury in db/db Diabetic Mice

Protective Effects of the Segmental Renal Artery Clamping Technique on Ischemia-Reperfusion Injury in db/db Diabetic Mice

Effects of Grape Seed Proanthocyanidin Extract in Attenuating Diabetic Complications in Streptozotocin-Induced Diabetic Rats

Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats

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