Plasma immune mediators as laboratorial biomarkers for Sickle Cell Disease patients according to the hydroxyurea therapy and disease severity

Toledo, Sílvia Letícia de Oliveira; Ladeira, Valéria Sutana; Nogueira, Leilismara Sousa; Ferreira, Letícia Gonçalves Resende; Oliveira, Marina Mendes; Renó, Cristiane de Oliveira; Santos, Herica L.; Coelho-dos-Reis, Jordana Grazziela Alves; Campi-Azevedo, Ana Carolina; Teixeira-Carvalho, Andréa; Martins‐Filho, Olindo Assis; Rios, Danyelle Romana Alves; Barros-Pinheiro, Melina

doi:10.1016/j.bcmd.2022.102703

Cited by 1 publication

(3 citation statements)

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“…This was investigated, and the results showed that methaemoglobin is an endogenous DAMP ligand for TLR2 and that neutrophils actively respond to the (metHb + LTA) induced production of ROS. Interestingly, it was also observed that this response diminishes in the presence of other white cells, indicating that cells of the immune system communicate with each other to modulate cellular responses during a haemolytic reaction [105] Vaso-occlusive crises (VOCs) occur when sickled red blood cells obstruct blood flow to the tissues [24,106,107]. This, in turn, triggers an inflammatory reaction as the body attempts to correct the condition.…”

Section: The Role Of Inflammation In the Pathogenesis Of Sickle Cell ...mentioning

confidence: 99%

“…Vaso-occlusive crises (VOCs) occur when sickled red blood cells obstruct blood flow to the tissues [ 24 , 106 , 107 ]. This, in turn, triggers an inflammatory reaction as the body attempts to correct the condition.…”

Section: The Role Of Inflammation In the Pathogenesis Of Sickle Cell ...mentioning

confidence: 99%

“…Others have supported this and have observed that patients receiving HU had lower interleukin IL-6 levels [ 134 , 135 ]. In contradiction, however, others have reported elevated levels of interleukin (IL)-6 compared to untreated patients [ 82 , 106 , 136 , 137 , 138 ].…”

Section: Other Treatment Optionsmentioning

confidence: 99%

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A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Aboderin,

Oduola,

Davison

et al. 2023

Biomedicines

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Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain haemoglobin gene resulting in the substitution of glutamic acid with valine. This mutation leads to the production of an abnormal haemoglobin molecule called haemoglobin S (HbS). When deoxygenated, haemoglobin S (HbS) polymerises and results in a sickle-shaped red blood cell which is rigid and has a significantly shortened life span. Various reports have shown a strong link between oxidative stress, inflammation, the immune response, and the pathogenesis of sickle cell disease. The consequence of these processes leads to the development of vasculopathy (disease of the blood vessels) and several other complications. The role of the immune system, particularly the innate immune system, in the pathogenesis of SCD has become increasingly clear in recent years of research; however, little is known about the roles of the adaptive immune system in this disease. This review examines the interaction between the immune system, inflammation, oxidative stress, blood transfusion, and their effects on the pathogenesis of sickle cell anaemia.

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Section: The Role Of Inflammation In the Pathogenesis Of Sickle Cell ...mentioning

confidence: 99%

Section: The Role Of Inflammation In the Pathogenesis Of Sickle Cell ...mentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

Aboderin,

Oduola,

Davison

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Plasma immune mediators as laboratorial biomarkers for Sickle Cell Disease patients according to the hydroxyurea therapy and disease severity

Cited by 1 publication

References 69 publications

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia

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