Plasma insulin and the time pattern of feeding in the rat

Blood Glucose Dynamics and Control of Meal Initiation: A Pattern Detection and Recognition Theory

“…Hepatic vagotomy abolished the insulin spike. Plasma insulin reached its lowest point just before the meal in most experiments as reported originally by Strubbe et al (124). These data suggest that a spike of insulin in the plasma, probably vagally mediated, may play a role in the origin of the transient declines in blood glucose that precede meal initiation (19,29).…”

Insulin secretion by rat islet isografts of a defined endocrine volume after transplantation to three different sites

“…A second catheter was implanted into the left jugular vein for the infusion of glucose. This technique allows frequent blood sampling and continuous infusion of fluids in unanaesthetized and freely moving rats [9][10][11]. Blood loss due to the sampling procedure was replaced by transfusing blood from a normal donor rat at regular intervals.…”

“…These sites have previously proven to be highly effective in the rodents. Graft function was tested in unanaesthetized and unstressed freely moving rats [9][10][11] not only by an intravenous glucose tolerance test (IVGTT) but also by the response to a meal, which is the most physiological stimulus for insulin secretion.…”

Carbohydrates and feeding: An extension of the glucostatic theory of appetite regulation

“…However, there was a significant decrease in insulin in small transient declines in blood glucose the 5 minutes before feeding indicating that this decrease in insulin may play a role in meal initiation. This may indicate that glucose utilization attains its lowest rate directly prior to feeding despite the constancy of the actual blood glucose concentration (Strubbe, Steffens and DeRuiter, 1977). The initial low blood glucose is most likely obtained following increased glucose utilization or decreased hepatic production of glucose.…”

“…shown that both blood glucose levels and glucose utilization in single-stomached 33 species increase during and after carbohydrate-containing meals (Strubbe & Steffens, 1977;Nicolaidis, 1981;Flatt et al 1985;Surina era/. 1993).…”