Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI

Ghaedian, Mohammad Mehdi; Jaz, Ali Nazari; Momeni, Mohsen; Ghaedian, Tahereh; Samiei, Najmeh

doi:10.1080/10641963.2018.1557684

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…Obese individuals have been reported to have significantly higher plasma leptin levels compared to eutrophic individuals 62. Most recently, plasma leptin level has been reported to be positively associated with increased blood pressure independent of gender and BMI 63. Recent findings demonstrate that 1,25(OH) 2 D 3 can counteract leptin-induced oxidative stress and inflammation in human umbilical vein endothelial cells.…”

Section: Vitamin D Regulates Circulating Lipids Blood Pressure and Imentioning

confidence: 95%

<p>Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being</p>

Moukayed¹,

Grant²

2019

DMSO

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The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased co-morbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D 3 can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D 3 can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D 3 intake to reduce cardiometabolic and metastatic disease and increase longevity.

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Section: Vitamin D Regulates Circulating Lipids Blood Pressure and Imentioning

confidence: 95%

<p>Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being</p>

Moukayed¹,

Grant²

2019

DMSO

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“…While under physiological condition, leptin supports nitric oxide release enhancing vasodilation [34]. In this manner, leptin contributes to onset of obesity associated hypertension [35,36].…”

Section: Leptin: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…Although they identified elevated level of leptin, patients did not show a significant variation as their blood pressure is measured. 132 However, mutation of leptin and its receptor may cause severe obesity in human beings, but normal or lower arterial pressure and sympathetic tone may be detected. [133][134][135] Obesity is a well-known risk factor for the development of hypertension.…”

Section: Leptin In the Pathogenesis Of Obesity-associated Hypertensionmentioning

confidence: 99%

Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication

Dessie¹,

Ayelign²,

Akalu³

et al. 2021

DMSO

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In response to obesity-associated chronic inflammatory disorders, adipose tissue releases a biologically active peptide known as leptin. Leptin activates the secretion of chemical mediators, which contribute to the pathogenesis of chronic inflammatory disorders, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and psoriasis. Conversely, adiposity and obesity are the major aggravating risk factors in the pathogenesis of metabolic syndrome (MetS), including type II diabetes mellitus and obesity-associated hypertension. Elevated level of leptin in obesity-associated hypertension causes an increase in the production of aldosterone, which also results in elevation of arterial blood pressure. Hyperleptinemia is associated with the progress of the atherosclerosis through secretion of pro-inflammatory cytokines, like interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), IL-17, and other cytokines to promote inflammation. The release of those cytokines leads to chronic inflammatory disorders and obesity-associated MetS. Thus, the aberrant leptin level in both MetS and chronic inflammatory disorders also leads to the complication of cardiovascular diseases (CVD). Therapeutic target of leptin regarding its pro-inflammatory effect and dysregulated sympathetic nervous system activity may prevent further cardiovascular complication. This review mainly assesses the mechanism of leptin on the pathogenesis and further cardiovascular risk complication of chronic inflammatory disorders.

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Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI

Cited by 12 publications

References 33 publications

<p>Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being</p>

<p>Linking the metabolic syndrome and obesity with vitamin D status: risks and opportunities for improving cardiometabolic health and well-being</p>

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication

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