Plasma lipids and coagulation in patients with arteriosclerotic dementia

Abstract

SYNOPSIS Plasma lipids and lipoproteins, glucose, uric acid, and haemocoagulative parameters were studied in a group of 22 elderly hospitalized patients with arteriosclerotic dementia, and compared with those of a control group of a similar age. No significant differences were found in lipids. lipoproteins, glucose, or uric acid but the fibrinogen level was significantly raised in the group with arteriosclerotic dementia. A comparison of the metabolic parameters of the dementia patients with those of a group of subjects with peripheral occlusive arteriosclerosis showed, on the other hand, that this latter group had significantly raised plasma triglycerides as well as a significantly higher incidence of the Fredrickson phenotypes of hyperlipoproteinaemia. These findings indicate that the common laboratory parameters used to evaluate arteriosclerosis are not adequate to point out any pathogenic mechanism for arteriosclerotic dementia, and research should therefore be focused in other directions.

Hemostatic Abnormalities in Dementia: A Systematic Review and Meta-Analysis

“…No differences were observed in activated partial thromboplastin time, 28,30 30,31 thrombin-antithrombin complex, 30,31 PAI-1, 30-34 t-PA, 30,31,33 activated protein C activity, 30,31 and platelet counts 28,35 between VD and controls. An increase in levels of fibrinogen (►Fig.…”

“…Andreoli et al did not observe differences in prothrombin time (PT) between VD patients and controls. 28 Similarly, Alonso et al 29 did not observe differences in plasminogen activator urokinase-type (u-PA) comparing VD patients with controls. Thirteen analytes were evaluated by more than one study, and the results together are given in ►Table 2.…”

“…An increase in levels of fibrinogen (►Fig. 3), 28,30,31,34,[36][37][38] activated factor (F) VII (FVIIa), 30,31,34 FVIII, 30,31 von Willebrand factor (VWF), 30,31,33,34 D-dimer, 30,31,34,36,39 and homocysteine 39,40 was observed in VD.…”