Plasma lipids, triglyceride/fatty acid pattern, and plasma insulin in fasted healthy volunteers during continuous ingestion of ethanol *1, *2Influence of lipolysis inhibited by Nicotinic Acid

Kaffarnik, H; Schneider, Jürgen; Schubotz, R; Hausmann, L; Mühlfellner, G; Mühlfellner, O; Zöfel, P.

doi:10.1016/0021-9150(78)90088-6

Cited by 18 publications

(13 citation statements)

References 20 publications

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“…The observed increase in the levels of FFA may be directly due to lipid breakdown and indirectly due to oxidation of ethanol to acetate and its conversion to FFAs. An increase in FFA levels can increase the synthesis of other major lipids and activate NADPH or NADH-dependent microsomal peroxidation (Kaffarnik et al 1978). On the other hand, decrease in FFA content, as in HMBA-treated ethanolfed rats, may lead to a decreased synthesis of CHO, TG, PL and extent of lipid peroxidation.…”

Section: Resultsmentioning

confidence: 99%

Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Saravanan

Nalini

2007

Journal of Pharmacy and Pharmacology

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The aim of the present study was to determine the effect of 2-hydroxy 4-methoxy benzoic acid (HMBA), the active principle of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant in India. We investigated the effect of HMBA on hyperlipidaemia induced by ethanol, exploring food intake, body weight, and hepatic and plasma lipids and lipoproteins. Male Wistar rats weighing 130-180 g were given ethanol (5 g kg(-1) p.o.) daily for 30 days. Subsequently, ethanol-fed rats were given HMBA intragastrically at a dose of 200 microg kg(-1) per day for 30 days. At the end of the total experimental period of 60 days, plasma concentrations of total cholesterol (CHO), triglycerides (TG), lipoproteins (LP), phospholipids (PL), free fatty acids (FFA) and lipoprotein lipase (LPL), and hepatic CHO, TG and PL were measured. Treatment of ethanol-fed rats with HMBA significantly decreased plasma CHO, TG, LP, PL and FFA and hepatic CHO, TG and PL, and increased plasma LPL concentrations compared with values in untreated ethanol-fed rats (all P<0.05). Food intake and average body weight at the end of the experimental period were significantly increased by HMBA administration. In conclusion, administration of HMBA decreased lipids and lipoprotein concentrations significantly in an animal model of ethanol-induced hyperlipidaemia.

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Section: Resultsmentioning

confidence: 99%

Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Saravanan

Nalini

2007

Journal of Pharmacy and Pharmacology

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“…Remla et al (1991) reported that administration of ethanol to rats caused changes in the metabolism of serum and tissue lipids. Several authors have reported that both acute and chronic ethanol consumption induced hypertriglyceridemia (Kaffarnik et al, 1978). Brodie et al (1961) showed that single oral doses of ethanol in rats induced an accumulation of liver triglycerides.…”

Section: Discussionmentioning

confidence: 99%

Adaptation of siblings of female rats given ethanol effect of N-acetyl-L-cysteine

1997

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Summary. Ethanol administration to female rats before and during pregnancy resulted in decreased number of litters and increased activities of serum GOT, GPT and ALP. The hepatotoxicity of ethanol was indicated by the histological alterations both in the mother and siblings. There was increased levels of tissue lipids in mother and litters born to alcoholic rats. The concentration of TBARS in the liver and kidney were significantly increased in alcohol treated rats and their litters. The activities of the anti-peroxidative enzymes SOD and CAT were decreased on alcohol treatment in female rats. The glutathione content in liver and kidney decreased significantly in litters born to alcoholic rats.We have observed that the treatment with N-acetylcysteine offers protection against the toxic effect of alcohol in female rats during pregnancy and litters born to them. In N-acetylcysteine treated rats the number of litters as well as the average birth weight were close to that of control animals. Nacetylcysteine decreases the activities of serum GOT, GPT and ALP in female rats. We have also observed decreased levels of tissue lipids in mother and litters born to alcoholic rats given N-acetylcysteine when compared to alcoholic rats. The levels of TBARS in liver, kidney were also decreased both in mother and litter born to alcohol + N-acetylcysteine, while the activities of SOD and CAT were increased in liver of alcoholic rats given N-acetylcysteine when compared to alcoholic rats. Histopathological studies also showed the protective effect of N-acetylcysteine in both mother and litter in liver and kidney against alcoholic induced toxicity.

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“…At the four-week observation time, the LDL cho¬ lesterol fraction was significantly increased both in the two-week and four-week groups (Fig 2, right) 55 Finally, retinoids are known to inhibit cell prolif¬ eration. This finding has led to speculation that retinoids may be useful in the prevention of athero¬ sclerosis by inhibiting intimai cell proliferation.56 Therefore, the possibility exists that this drug may decrease coronary heart disease even though it ele¬ vates plasma lipid levels.…”

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confidence: 96%

Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin. A prospective study

Zech¹

1983

Archives of Dermatology

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Twenty men with nodulocystic acne were treated with oral isotretinoin (13-cis-retinoic acid) for four months. Plasma lipids and lipoprotein determinations were obtained before and during treatment to quantitate the effects of oral isotretinoin on lipid metabolism. Maximum isotretinoin-induced elevations in plasma triglyceride and cholesterol levels were 67% and 16%, respectively. Additional maximal changes included very-low-density lipoprotein cholesterol increases of 56%, low-density lipoprotein cholesterol increases of 22%, and high-density lipoprotein decreases of 10% from pretreatment values. Chronic increases in plasma cholesterol levels, increases in low-density lipoprotein cholesterol levels, and decreases in high-density lipoprotein cholesterol levels may predispose subjects to premature atherosclerosis. Because of the potential for unmasking an occult lipid or lipoprotein disorder, the plasma lipid and lipoprotein profiles of subjects receiving isotretinoin should be carefully monitored.

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Plasma lipids, triglyceride/fatty acid pattern, and plasma insulin in fasted healthy volunteers during continuous ingestion of ethanol 1, 2Influence of lipolysis inhibited by Nicotinic Acid

Cited by 18 publications

References 20 publications

Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

Adaptation of siblings of female rats given ethanol effect of N-acetyl-L-cysteine

Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin. A prospective study

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