Plasma malondialdehyde in type 1 and type 2 diabetic patients

Gallou, G; Ruelland, A.; Legras, B; Maugendre, D; Allannic, H; Cloarec, L

doi:10.1016/0009-8981(93)90114-j

Cited by 145 publications

(92 citation statements)

References 16 publications

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“…Our results are in accordance with previous studies [14][15][16][17]. Increased oxidative stress and free radical generation may be the cause of increase in MDA level which is the marker for lipid peroxidation.…”

Section: Discussionsupporting

confidence: 93%

A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients

G.K

Rahman

Patil

2016

Int J of Biomed & Adv Res

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Background: Diabetes mellitus is an endocrinal disorder. Over production of reactive oxygen and nitrogen species thought to be involved in the initiation and development of vascular complications in diabetes. Increased levels of MDA, Vitamin E and Ceruloplasmin are the markers for oxidative stress in type 2 diabetes mellitus. The aim of the present study is to study the Antioxidant status in Type 2 Diabetes patients. Materials & Methods:This, case control study was conducted on 40 subjects. Among them 20 were controls, 20 were known Type 2 Diabetes patients. Patients with T2DM with other endocrinal disorders, patients on antioxidants, minerals and multivitamins as supplement form are excluded from the study. A laboratory investigations consisting of glucose, total cholesterol, triglycerides, HDLC, LDLC Vitamin E, MDA and Ceruloplasmin were carried out on fasting blood sample of subjects selected for this study. Results: In the present study, FBS, PPBS, MDA, Ceruloplasmin, total cholesterol and LDLC were significantly increased in T2DM cases and HDLC, Vitamin E was significantly decreased in cases when compared to controls. (p value <0.05). Conclusion:The findings of this study is in accordance to earlier studies, that there is an increased oxidative stress in diabetics compared to controls; and the oxidative stress further increases as diabetes to cardiovascular diseases. This study emphasizes the importance of assessing the antioxidant status in diabetes in addition to the markers of oxidative stress and lipid profile to formulate the specific therapies for early therapeutic intervention and better treatment of diabetes mellitus.

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Section: Discussionsupporting

confidence: 93%

A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients

G.K

Rahman

Patil

2016

Int J of Biomed & Adv Res

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“…In addition to this plasma SOD and CAT activities were found lower in type 2 diabetic group than control group. Malondialdehyde is one of the lipid peroxidation products frequently used to determine the oxidant/antioxidant balance in diabetic patients (Altomare et al 1992;Gallou et al 1993). However, there are contradictory results in literature about serum MDA levels in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Resistance to Oxidation in Patients with Type 2 Diabetes Mellitus

Paşaoğlu

Sancak

Bukan

2004

Tohoku J. Exp. Med.

101

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We investigated lipid peroxidation, resistance of plasma and red blood cells to oxidation, and antioxidant defense system in erythrocytes and sera in patients with type 2 diabetes mellitus. One group included newly diagnosed 20 patients and the other included 20 patients treated with oral antidiabetic agents (OAD). Twenty healthy subjects served as controls. Serum and red blood cell malondialdehyde (MDA), glutathione (GSH), resistance to oxidation, and plasma thiol (total -SH) levels were measured. In addition, glycated hemoglobin, serum fructosamine, uric acid, total protein, total cholesterol, triglyceride and glucose levels were determined. Although newly diagnosed patients had higher serum and erythrocyte MDA levels than those of controls, the highest levels of MDA were determined in patients treated with OAD. MDA levels after exposing to oxidation increased in OAD group more than in newly diagnosed patients. Total -SH and erythrocyte GSH levels of the both diabetic groups were lower than controls. These results show that serum and erythrocyte lipid peroxidation was increased in diabetic patients. The sera of the patients showed a decreased resistance against oxidation. We therefore suggest that the effect of increased free radicals may be prevented by antioxidant systems in early stages of type 2 diabetes but in advanced stages this relationship is impaired owing to decreased antioxidant activity. Decreased red blood cell GSH and serum total -SH levels may be due to a compensation mechanism of the antioxidants. diabetes mellitus; lipid peroxidation; antioxidants

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“…Malonyldialdehyde (MDA) is frequently measured as an indicator of oxidative stress in vivo and is elevated in diabetic patients with macroangiopathy or microalbuminuria [19,20].…”

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confidence: 99%

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

et al. 2009

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Aims/hypothesis This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes. Methods The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were identified and the following variables evaluated: fasting plasma glucose, HbA 1c , malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine, estimated GFR and lipid profile. Results Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER <20 μg/min) and 62 with microalbuminuria (AER ≥20 μg/min). The following variables were significantly higher in patients with microalbuminuria than in those without microalbuminuria (mean ± SD): fasting plasma glucose 9.41±2.88 vs 8.19±1.93 mmol/l, p<0.05; HbA 1c 7.97±1.51 vs 7.39± 1.03%, p<0.05; MDA 1.18±0.35 vs 1.02±0.29 µmol/l, p< 0.05; pentosidine 98.5±24.6 vs 82.9±20.9 pmol/ml, p< 0.005; and AGE 13.2±4.8 vs 10.6±3.8 µg/mg protein, p< 0.01. However, vitamin E and TRAP did not differ between the two groups. Serum creatinine values and estimated GFR were similar in the two groups. Only in patients with microalbuminuria were significant linear correlations seen between AER and both oxidation (HbA 1c r=0.33, p<0.01; MDA r=0.59, p<0.001; pentosidine r=0.48, p<0.001; and AGE r=0.44, p<0.001) and antioxidation variables (vitamin E r=−0.55, p<0.001; TRAP r=−0.49, p<0.001). Considering all variables together, multiple regression revealed a correlation between microalbuminuria and vitamin E, TRAP, HbA 1c and MDA, but not pentosidine or AGE. Conclusions/interpretation Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.

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Plasma malondialdehyde in type 1 and type 2 diabetic patients

Cited by 145 publications

References 16 publications

A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients

A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients

Lipid Peroxidation and Resistance to Oxidation in Patients with Type 2 Diabetes Mellitus

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

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