2017
DOI: 10.1155/2017/6270195
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Plasma Metabolomics Analysis Based on GC‐MS in Infertile Males with Kidney‐Yang Deficiency Syndrome

Abstract: Introduction Chinese medicine syndrome diagnosis is the key requisite in the treatment of male infertility with traditional Chinese medicine (TCM). Kidney-Yang deficiency syndrome (KYDS) is the critical Chinese medicine syndrome of male infertility. To explore the modernized mechanisms of KYDS in male infertility, this study aims to investigate the metabolomics of males with KYDS. Methods The gas chromatography-mass spectrometry method was applied to analyze the plasma samples of 67 infertile males with KYDS c… Show more

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Cited by 16 publications
(5 citation statements)
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“…In the plasma of MI patients with Kidney De ciency, metabolic pathways such as alanine, aspartate, and glutamate metabolism, as well as D-glutamine and D-glutamate metabolism, exhibit manifest anomalies [43] , in accordance with the data presented in Table 1. Among the 23 critical metabolites, amino acids constituted the majority, accounting for approximately 47.83% of the total.…”
Section: Urinary Metabolic Of MI and Identi Cation Of Highly Associat...supporting
confidence: 87%
“…In the plasma of MI patients with Kidney De ciency, metabolic pathways such as alanine, aspartate, and glutamate metabolism, as well as D-glutamine and D-glutamate metabolism, exhibit manifest anomalies [43] , in accordance with the data presented in Table 1. Among the 23 critical metabolites, amino acids constituted the majority, accounting for approximately 47.83% of the total.…”
Section: Urinary Metabolic Of MI and Identi Cation Of Highly Associat...supporting
confidence: 87%
“…KYDS is a vital traditional Chinese medicine syndrome of male infertility. Zheng et al () established a GC‐MS metabolomics method to explore the modernization mechanism of KYDS in male infertility. In this study, 67 infertile males with KYDS and 55 healthy controls were enrolled, and 37 potential biomarkers and 6 metabolic pathways were identified, of which, 10 biomarkers could distinguish infertile males with KYDS from healthy people to highlight the machanism.…”
Section: Mass Spectrometry Techniques Employed In Metabolomicsmentioning
confidence: 99%
“…In the plasma of MI patients with Kidney Deficiency, metabolic pathways such as alanine, aspartate, and glutamate metabolism, as well as D-glutamine and D-glutamate metabolism, exhibit manifest anomalies [ 74 ], according to the data presented in Table 1 . Among the 23 critical metabolites, amino acids constituted the majority, accounting for approximately 47.83% of the total.…”
Section: Discussionmentioning
confidence: 99%