2022
DOI: 10.1172/jci.insight.154999
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Plasma metabolomics study reveals the critical metabolic signatures for benzene-induced hematotoxicity

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Cited by 18 publications
(7 citation statements)
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“…The results showed that exposure to benzene leads to alterations in carnitine transport, fatty acid metabolism, sulfur amino acid metabolism, glycolysis, gluconeogenesis, and branched-chain amino acid metabolism. Mono- and polyunsaturated and short-chain fatty acids are also significantly associated with S-phenylmercapturic acid and leukocytes, and reported as key mediators of benzene-induced hematotoxicity in the study by Guo et al (2022) [ 91 ].…”
Section: Resultsmentioning
confidence: 99%
“…The results showed that exposure to benzene leads to alterations in carnitine transport, fatty acid metabolism, sulfur amino acid metabolism, glycolysis, gluconeogenesis, and branched-chain amino acid metabolism. Mono- and polyunsaturated and short-chain fatty acids are also significantly associated with S-phenylmercapturic acid and leukocytes, and reported as key mediators of benzene-induced hematotoxicity in the study by Guo et al (2022) [ 91 ].…”
Section: Resultsmentioning
confidence: 99%
“…The basic characteristics (Supplementary Table S3) and hematological indicators of the subjects were described in our previous study. 28 In the present study, we obtained informed consent from all subjects, and the protocol was approved by the Ethics and Human Subject Committee of Capital Medical University (2017054).…”
Section: Methodsmentioning
confidence: 99%
“…Internal standards were added to the test samples in order to monitor analytical variations during the entire sample preparation and analysis processes. 20…”
Section: Metabolomics Assaysmentioning
confidence: 99%