2019
DOI: 10.21688/1681-3472-2019-1-33-41
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Plasma mitochondrial DNA level as an early marker of systemic inflammatory response syndrome and organ failure in patients undergoing cardiac surgery

Abstract: <p><strong>Aim.</strong> To assess whether plasma mitochondrial DNA (mtDNA) levels in the early postoperative period can predict the development of systemic inflammatory response syndrome (SIRS) and multiple organ failure in patients undergoing cardiac surgery.</p><p><strong>Methods.</strong> This pilot, prospective, observational, cohort study included 85 patients undergoing cardiac surgery. Plasma mtDNA levels were determined immediately after the surgery, and the de… Show more

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“…Cardiopulmonary bypass, surgical trauma, and ischemia–reperfusion injury stimulate a systemic inflammatory response in cardiac surgery. Early postoperative plasma mtDNA level is a predictive marker for SIRS and multi-organ failure in patients undergoing cardiac surgery ( 93 ). The elevated plasma mtDNA level during cardiopulmonary bypass (CPB) surgery may be involved in SIRS pathogenesis and the related postoperative inflammatory events (such as postoperative atrial fibrillation and infection) ( 67 ).…”
Section: Organ-level Evaluation Of Trauma-related Sirs Induced By Mtd...mentioning
confidence: 99%
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“…Cardiopulmonary bypass, surgical trauma, and ischemia–reperfusion injury stimulate a systemic inflammatory response in cardiac surgery. Early postoperative plasma mtDNA level is a predictive marker for SIRS and multi-organ failure in patients undergoing cardiac surgery ( 93 ). The elevated plasma mtDNA level during cardiopulmonary bypass (CPB) surgery may be involved in SIRS pathogenesis and the related postoperative inflammatory events (such as postoperative atrial fibrillation and infection) ( 67 ).…”
Section: Organ-level Evaluation Of Trauma-related Sirs Induced By Mtd...mentioning
confidence: 99%
“…MtDNA/cGAS/STING signaling pathway inhibits endothelial proliferation and vascular repair by downregulating YAP signal (91). MtDAMPs influence endothelial cells and neutrophils through diverse signals, which can promote the adherence and interactions of neutrophils to endothelial cells, consequently elevating systemic endothelial permeability (92).…”
Section: Dysfunction Of Blood Vesselmentioning
confidence: 99%
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