Plasma nesfatin 1 level in patients with first attack psychosis

Abstract

OBJECTIVES: This study aimed to investigate the possible relationship between plasma concentrations of nesfatin 1 and fi rst attack psychosis. METHODS: Totally, 32 patients with the fi rst episode psychosis and 33 randomly selected weight-and body mass index-matched healthy volunteers admitted to Mustafa Kemal University, Faculty of Medicine, Training and Research Hospital, Psychiatry outpatient clinic were included. Healthy control subjects were matched in terms of weight and body mass index (BMI). The Positive and Negative Syndrome Scale (PANNS) was applied to the patient group. The enzyme-linked immunosorbent assay (ELISA) method was used to measure plasma nesfatin 1 levels. RESULTS: The mean nesfatin 1 level was lower in the patients with the fi rst attack psychosis (0.60 ± 1.00 ng/mL) than in the control group (0.75 ± 1.07 ng/mL).However it did not reach statistical signifi cance (t = -0.567, p = 0.573). There was no statistically signifi cant correlation between plasma nesfatin 1 levels and total PANNS scores in the patient group (r = -0.262, p = 0.148). CONCLUSION: Our study was the fi rst to investigate the nesfatin 1 levels in patients with the fi rst episode psychosis. Based on our study results, nesfatin 1 might be related to some central nervous system pathologies, including the severity of a psychiatric disorder; however, further large-scale studies are required to establish a conclusion (Tab. 1, Ref. 21). Text in PDF www.elis.sk. KEY WORDS: fi rst attack psychosis, plasma nesfatin 1, body mass index.

Nesfatin-1 and cortisol: potential novel diagnostic biomarkers in moderate and severe depressive disorder

“…Nesfatin-1, a novel satiety molecule, has been reported to be involved in a variety of affective disorders, including anxiety disorder, 24 depression, 13 and psychosis. 25 Clinical studies have shown that the average nesfatin-1 level in MDD patients is statistically higher than that in the control group. 12 Similarly, plasma nesfatin-1 levels were also increased in rat subjected to avoiding stress, an acute depression model.…”

Metabolic syndrome following a first episode of psychosis: results of a 1-year longitudinal study conducted in metropolitan Lisbon, Portugal

“… 71 These immunological changes include high concentrations of pro-inflammatory cytokines and chemokines in the circulation and cerebrospinal fluid, as well as changes in immune cell function in the central nervous system. 72 , 73 Adipose tissue directly or indirectly secretes pro-inflammatory cytokines and proteins (IL-6, TNF-α, insulin-like growth factor-1, leptin, resistin, apelin, visfatin, CCL22, and nesfatin-1), 30 , 31 , 33 , 74 and patients with schizophrenia also show activation of microglia, which contributes to the high serum concentrations of pro-inflammatory cytokines. 73 , 75 Some of these substances are present and/or have receptors in parts of the central nervous system, but their exact roles in the pathophysiology of psychosis are still being studied.…”

“… 32 Several previous studies have demonstrated that high circulating concentrations of these substances are present in patients with psychotic disorders, both during the early and later phases. 30 , 31 , 33 Several types of adipokine receptors have been identified in components of the central nervous system and have been demonstrated to affect brain function. 34 This provides an important link between obesity/MetS and psychotic disorders, namely greater monocyte/macrophage activation and inflammation.…”

Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence

“…Nesfatin-1, another new anorexigenic peptide hormone, plays an important role in the integration of food intake, energy expenditure, and glucose homeostasis (9). In the past decade, nesfatin-1 has been found to be involved in a variety of affective disorders, including anxiety disorder (10), depression (11), and psychosis (12). However, no studies on the relationship between nesfatin-1 in AD and craving have been conducted.…”