Plasma nitrite/nitrate concentrations in patients with schizophrenia

Djordjević, Vladimir; Stojanović, Ivana; Stankovic-Ferlez, D.; Ristić, Tatjana; Lazarević, D; Ćosić, Vladan; Djordjević, Vidosava

doi:10.1515/cclm.2010.014

Cited by 20 publications

(9 citation statements)

References 33 publications

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“…Furthermore, administration of NOS substrate and NO precursor, L-arginine, can overcome the antidepressant effects of NOS inhibitors. This finding supports the involvement of NO pathway in these behavioral responses (Djordjević et al, 2010).…”

Section: Discussionsupporting

confidence: 86%

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Antidepressant effects of Mentha pulegium in mice

Rabiei

Gholami

Rafieian-Kopaei

2016

Bangladesh J Pharmacol

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The aim of this study is to investigate the antidepressant effects of Mentha pulegium essential oil in BALB/c mice. Six experimental groups (7 mice each) were used. Forced swim test was performed 30 min after essential oil injection. In the groups receiving M. pulegium essential oil (50, 75 and 100 mg/kg), immobility duration significantly decreased compared to the control group. M. pulegium (50 and 75 mg/kg) resulted in significant decrease in nitrate/nitrite content in serum compared to the control group. M. pulegium essential oil antidepressant effect that may be due to the inhibition of oxidative stress. The results showed that decrease in nitrate/nitrite content in serum and high anti-oxidant effects of M. pulegium essential oil.Video clip:<a href="https://youtube.com/v/qfmjCf5FNMk">Immobility in Forced Swim Test</a>: 13 sec<a href="https://youtube.com/v/oqWS13JzQtQ">Mobility in Forced Swim Test</a>: 19 sec

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Section: Discussionsupporting

confidence: 86%

“…Although NO has some useful effects, if produced excessively, it may exert toxic effects because of producing reactive nitrogen species and nitrolyzing proteins. The products derived from NO (nitrate + nitrite) can exert both peroxidant and antioxidant effects on lipids peroxidation depending on the conditions (Djordjević et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Antidepressant effects of Mentha pulegium in mice

Rabiei

Gholami

Rafieian-Kopaei

2016

Bangladesh J Pharmacol

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“…6 For example, research has shown elevated NO and NOS expression levels in the brain and plasma samples of schizophrenic individuals. 19 , 20 , 21 Human genetic and metabolomics studies have identified schizophrenia risk genes encoding nNOS (NOS1) and several downstream effectors of nNOS, 7 , 22 , 23 , 24 and reported disturbed biosynthetic and signalling pathways linked to arginine metabolism 25 , 26 and reduced expression in genes involved in the regulation of l -ornithine and polyamine metabolism. 26 Other studies have demonstrated decreased plasma arginase activity in schizophrenic patients, 9 and a positive correlation between the serum levels of l -ornithine and the duration of illness.…”

Section: Introductionmentioning

confidence: 99%

Altered brain arginine metabolism in schizophrenia

Liu

Collie

et al. 2016

Transl Psychiatry

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Previous research implicates altered metabolism of l-arginine, a versatile amino acid with a number of bioactive metabolites, in the pathogenesis of schizophrenia. The present study, for we believe the first time, systematically compared the metabolic profile of l-arginine in the frontal cortex (Brodmann's area 8) obtained post-mortem from schizophrenic individuals and age- and gender-matched non-psychiatric controls (n=20 per group). The enzyme assays revealed no change in total nitric oxide synthase (NOS) activity, but significantly increased arginase activity in the schizophrenia group. Western blot showed reduced endothelial NOS protein expression and increased arginase II protein level in the disease group. High-performance liquid chromatography and liquid chromatography/mass spectrometric assays confirmed significantly reduced levels of γ-aminobutyric acid (GABA), but increased agmatine concentration and glutamate/GABA ratio in the schizophrenia cases. Regression analysis indicated positive correlations between arginase activity and the age of disease onset and between l-ornithine level and the duration of illness. Moreover, cluster analyses revealed that l-arginine and its main metabolites l-citrulline, l-ornithine and agmatine formed distinct groups, which were altered in the schizophrenia group. The present study provides further evidence of altered brain arginine metabolism in schizophrenia, which enhances our understanding of the pathogenesis of schizophrenia and may lead to the future development of novel preventions and/or therapeutics for the disease.

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“…Similar results have been published in relation to NO. The baseline plasma NO levels were found significantly lower (24) or significantly higher (25, 26) in schizophrenics than in controls. Antipsychotic treatment did not induce any significant difference in NO levels, neither in patients who had significantly higher NO levels (27) nor in those with significantly lower concentrations (28).…”

Section: Introductionmentioning

confidence: 74%

Diagnostic Accuracy of Brain-derived Neurotrophic Factor and Nitric oxide in Patients with Schizophrenia. A pilot study/ Dijagnostička tačnost moždanog neurotrofičkog faktora i azot-monoksida kod obolelih od shizofrenije.Pilot studija

Djordjević¹,

Lazarević

Ćosić³

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundBrain-derived neurotrophic factor (BDNF) and nitric oxide (NO) play multiple roles in the developing and adult CNS. Since BDNF and NO metabolisms are dysregulated in schizophrenia, we measured these markers simultaneously in the blood of schizophrenics and assessed their diagnostic accuracy.MethodsThirty-eight patients with schizophrenia classified according to demographic characteristics, symptomatologyand therapy and 39 age- and gender-matched healthy controls were enrolled. BDNF was determined by the ELISA technique while the concentration of nitrite/nitrate (MJX-TeXAtom-ORDNO2−MJX-TeXAtom-ORD/MJX-TeXAtom-ORDNO3−) was measured by the colorimetric method.ResultsSerum BDNF levels were significantly lower (20.38±3.73 ng/mL, P = 1.339E-05), whilst plasma MJX-TeXAtom-ORDNO2−MJX-TeXAtom-ORD/MJX-TeXAtom-ORDNO3− concentrations were significantly higher (84.3 (72–121) μmol/L, P=4.357E-08) in patients with schizophrenia than in healthy controls (25.65±4.32 ng/mL; 60.9 (50–76) μmol/L, respectively). The lowest value of BDNF (18.14±3.26 ng/mL) and the highest MJX-TeXAtom-ORDNO2−MJX-TeXAtom-ORD/MJX-TeXAtom-ORDNO3− concentration (115.3 (80–138) μmol/L) were found in patients treated with second-generation antipsychotics (SGA). The patients diseased before the age of 24 and the patients suffering for up to one year had significantly lower serum BDNF levels than those diseased after the age of 24 and the patients who were ill longer than one year. Both BDNF and MJX-TeXAtom-ORDNO2−MJX-TeXAtom-ORD/MJX-TeXAtom-ORDNO3− showed good diagnostic accuracy, but BDNF had better ROC curve characteristics, especially in patients with negative symptomatology.ConclusionsBDNF and nitrite/nitrate showed inverse changes in schizophrenic patients. The most pronounced changes were found in patients treated with second-generation antipsychotics. Although BDNF is not specific of schizophrenia, it may be a clinically useful biomarker for the diagnosis of patients expressing predominantly negative symptoms.

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Plasma nitrite/nitrate concentrations in patients with schizophrenia

Cited by 20 publications

References 33 publications

Antidepressant effects of <i>Mentha pulegium</i> in mice

Antidepressant effects of <i>Mentha pulegium</i> in mice

Altered brain arginine metabolism in schizophrenia

Diagnostic Accuracy of Brain-derived Neurotrophic Factor and Nitric oxide in Patients with Schizophrenia. A pilot study/ Dijagnostička tačnost moždanog neurotrofičkog faktora i azot-monoksida kod obolelih od shizofrenije.Pilot studija

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