Plasma-Noradrenaline in Essential Hypertension

Birch, M; Tunbridge, R. D. G.; Sever, PS; Osikowska, Barbara A.

doi:10.1016/s0140-6736(77)92335-2

Cited by 53 publications

(2 citation statements)

References 15 publications

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“…Interventional RDN is based on the paradigm of an elevated sympathetic activity in people with hypertension. [2,3] The clinical relevance of this paradigm is supported by the blood pressure (BP) lowering effects of thoracolumbar sympathectomy in the first half of the 20th century. [4,5] While the role of sympathetic overactivity in elevating BP is well established, this does not necessarily mean any interventional RDN is successful in any hypertensive patient.…”

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confidence: 99%

“…Elevated sympathetic activity cannot be found in all patients with hypertension, especially elderly people. [2,3] In this group, biomechanical components such as vascular stiffening and increased wave reflections might outweigh the sympathomimetic contributors to an elevated BP. [11,12] Second, interference with antihypertensive medication, medication adherence and changes in treatment influence the effects of RDN on BP.…”

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confidence: 99%

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Lessons Learned from RADIOSOUND-HTN: Different Technologies and Techniques for Catheter-based Renal Denervation and Their Effect on Blood Pressure

Lurz

Fengler

2019

Interv Cardiol

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The interest in renal denervation (RDN) as a treatment for arterial hypertension has returned with three proof of principle trials that have shown recently RDN to be superior to sham treatment. Nevertheless, many questions about this treatment remain open, including those around the optimal interventional technique and technology. To clarify this important question, the authors designed and conducted the Randomized Trial of Different Renal Denervation Devices and Techniques in Patients with Resistant Hypertension (RADIOSOUND-HTN) trial, which compared three RDN treatment arms in a prospective randomised clinical trial. In this article, they comment on the background and results of this trial, and discuss which conclusions can be drawn from the trial, and which questions remain open for future studies in this field.

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confidence: 99%