Plasma Omentin-1 Level and its Relationship with Insulin Resistance in Obese Prediabetics

Kaushik, Nalini; Kaushik, Ravi; Dixit, Piyush; Tyagi, Mool Kumar; Gambhir, Jasvinder K.; Madhu, SV; R, Shukla

doi:10.7860/jcdr/2018/31845.11432

Cited by 3 publications

(9 citation statements)

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“…Mean age of the participants ranged between 11 and 67 years. Twenty-one studies recruited both gender, 17,19,[22][23][24]27,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] four were conducted only in men, 18,21,25,47 and three used female subjects. 20,26,48 Included studies were conducted in participants with T1DM, 17,32,40 T2DM 22,23,26,27,38,39,41,[43][44][45][46][47] , and patients with IGT.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…20,26,48 Included studies were conducted in participants with T1DM, 17,32,40 T2DM 22,23,26,27,38,39,41,[43][44][45][46][47] , and patients with IGT. 18,21,24,42 Seven studies enrolled normal weight (BMI<24.9) subjects, 23,32,33,36,44-46 13 recruited overweight participants (24.9≤BMI≤29.9) 17,18,21,22,25,27,34,38,39,41,43,47,48 and 6 were conducted on obese subjects 20,24,26,35,37,42 but 2 studies did not mention baseline BMI. 19,40 Two studies were cross sectional 35,37 and the others were casecontrol.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…19,40 Two studies were cross sectional 35,37 and the others were casecontrol. [17][18][19][20][21][22][23][24][25][26][27][32][33][34]36,[38][39][40][41][42][43][44][45][46][47][48] Based on the NOS, 10 studies ranked as high-quality 23,27,32,35,37,40,41,43,44,47 and the others as were classified as moderate in quality assessment.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…Twenty-eight studies with 2941 participants examined serum omentin level among patients with diabetes (T1DM, T2DM, and IGT) and healthy subjects. [17][18][19][20][21][22][23][24][25][26][27][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). There was evidence of heterogeneity between the effect sizes of the included studies (I 2 =96.9% p<0.001).…”

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

“…14 Based upon previous reports, plasma omentin levels inversely correlate with body mass index (BMI), fat mass, and fasting plasma insulin, and positively with insulin sensitivity, adiponectin, high-density lipoprotein cholesterol, and endothelial function. [15][16][17][18] However, increasing body of literature has shown paradoxical relationships between serum omentin and diabetes with some studies suggesting a significant association between serum omentin level and diabetes [19][20][21][22][23] while others do not support such an association. 18,[24][25][26][27] Currently, there is insufficient evidence showing whether serum omentin is related to diabetes, and determination of this relationship has rarely been conducted.…”

Section: Introductionmentioning

confidence: 99%

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Aims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population. Methods: PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of each study. Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). The result of our subgroup analysis based on participants' health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls. Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.

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Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

et al. 2019

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ObjectivePrevious studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship.MethodsStudies related to this outcome were obtained using a systematic search in the electronic databases of Cochrane Library, PubMed, Embase, SCOPUS, Google Scholar, gray literature and Web of Science in September 2019. The random effects model was used to measure the strength of the association between diabetes mellitus and concentrations of omentin-1, using standardized mean difference.ResultsForty-two eligible studies were included in the final meta-analysis. There was no significant difference in omentin-1 concentration between patients with type 1 diabetes mellitus and the controls. On the other hand, lower concentration levels of omentin-1 were observed in patients with gestational diabetes mellitus (standardized mean difference:-0.44, 95% confidence interval:-0.76; -0.12, p = 0.007), or type 2 diabetes mellitus (standardized mean difference: -1.74, 95% confidence interval: -2.31; -1.16, p< 0.001) than in the controls.ConclusionDecreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus. More studies are needed to validate this hypothesis and evaluate the role of omentin-1 concentrations in type 1 diabetes mellitus.

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Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2

Mohammad

Sallam

Fekry

et al. 2021

The Egyptian Journal of Hospital Medicine

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Introduction: Omentin-1, is an adipokine, inhibits TNF-induced inflammation of vascular smooth muscle cells, so its decreased levels in plasma of patients with coronary artery disease (CAD), indicated that omentin-1 may also be involved in the occurrence of CAD. Objective: Study the alternation of plasma levels of omentin-1 and chemerin in patients with coronary artery diseases. Patients and methods: This case-control study was carried out on 120 patients with coronary artery disease and 50 healthy volunteers, in the period from January 2018 to June 2019, divided into control group: 50 healthy volunteers, stable angina pectoris group: 60 cases, acute coronary syndrome (ACS) group: 60 cases, which were subclassified into; (a) 20 unstable angina (USA) cases; (b) 20 segment elevation myocardial infarction (STEMI) cases; (c) 20 non ST segment elevation myocardial infarction (NSTEMI) cases. Results: There was a highly significant difference between the studied groups in hsCRP, omentin-1 and chemerin levels with significant difference in SA group and ACS groups compared to control group. Regarding acute coronary syndrome (ACS) groups, there was significant difference in hsCRP between USA and infarction groups. Chemerin showed significant difference between USA and STEMI and USA and Non STE MI. While omentin-1 showed no significant difference between ACS subgroups. Regarding CAD without DM type2 and CAD with DM type2. There was high statistical significant difference between the groups as regarding FBG, HbA1c, total cholesterol (T. Chol), HDL-C, LDL-C, hsCRP, chemerin and omentin-1. Conclusion: increasing total cholesterol, triglycerides, LDL-C, high-sensitivity C-reactive protein (hsCRP) and chemerin. Decreasing HDL-C and Omentin-1 are independent predictors of CAD in type 2 diabetic patients.

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Plasma Omentin-1 Level and its Relationship with Insulin Resistance in Obese Prediabetics

Cited by 3 publications

References 0 publications

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

Omentin-1 in diabetes mellitus: A systematic review and meta-analysis

Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2

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