Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome

Orlik, Bartłomiej; Madej, Paweł; Owczarek, Aleksander; Skałba, Piotr; Chudek, Jerzy; Olszanecka-Glinianowicz, Magdalena

doi:10.1111/cen.12381

Cited by 39 publications

(46 citation statements)

References 31 publications

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“…Additionally, our study revealed an inverse correlation between circulating AMH and omentin‐1 levels that was strengthened by the results of multiple regression analysis showing that circulating AMH level variability is explained by omentin‐1 levels, independent of parameters describing nutritional status. The inconsistency seems to be the result of differences in adipose tissue hormonal function in PCOS and in non‐PCOS women, as was described in our previously published studies . We observed lower apelin‐36 and adiponectin levels but higher leptin and omentin‐1 levels in obese compared to normal weight PCOS women .…”

Section: Discussionsupporting

confidence: 73%

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Circulating anti‐Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome

Olszanecka-Glinianowicz

Madej

Owczarek

et al. 2015

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 73%

“…So far, there is a lack of studies that assess the relationships between circulating AMH and adipokines levels in PCOS. Our previously published studies revealed changes of circulating adiponectin, apelin, leptin and omentin‐1 levels in PCOS …”

Section: Introductionmentioning

confidence: 91%

Circulating anti‐Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome

Olszanecka-Glinianowicz

Madej

Owczarek

et al. 2015

Clinical Endocrinology

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“…Excessive visceral fat depot and its hormonal disturbances seem to play a role in hormonal and metabolic disturbances in PCOS (28,29,30,31,32). As described earlier, the novel adipokine FGF21 may play a role in the PCOS-related metabolic disturbances.…”

Section: Introductionmentioning

confidence: 72%

Circulating FGF21 levels are related to nutritional status and metabolic but not hormonal disturbances in polycystic ovary syndrome

Olszanecka-Glinianowicz¹,

Madej²,

Wdowczyk³

et al. 2015

European Journal of Endocrinology

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Objective: The aim of this study was to analyse relationships between plasma fibroblast growth factor 21 (FGF21) levels and nutritional status, and metabolic and hormonal disturbances in polycystic ovary syndrome (PCOS) women. Design and setting: A cross-sectional study involving 85 PCOS (48 obese) and 72 non-PCOS women (41 obese) was conducted to evaluate the relationship between FGF21 levels and PCOS. Methods: Anthropometric parameters and body composition were determined. In the fasting state; serum concentrations of glucose, androgens, FSH, LH, SHBG, insulin and FGF21 were measured. Results: Plasma FGF21 levels were significantly higher in obese women compared with normal-weight women in both PCOS and non-PCOS subgroups (120.3 (18.2-698) vs 62.3 (16.4-323.6) pg/ml, P!0.05 and 87.2 (12.9-748.4) vs 62.9 (18.0-378.8) pg/ml, P!0.05 respectively). Additionally, circulating FGF21 levels were significantly higher in the obese PCOS subgroup compared with the non-PCOS subgroup (120.3 (18.2-698.0) vs 87.2 (12.9-748.4) pg/ml, P!0.05). Circulating FGF21 levels were proportional to BMI (RZ0.27; P!0.001), body fat mass (RZ0.24; P!0.01) and percentage (RZ0.24; P!0.01), as well as waist circumference (RZ0.26; P!0.01). Additionally, plasma insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were related to FGF21 levels (RZ0.44; P!0.001 and RZ0.19; P!0.05 respectively). In multiple regression analysis, circulating FGF21 level variability was explained by HOMA-IR values and fat percentage, as well as waist circumference, but not correlated with oestradiol levels and free androgen index values. Conclusions: Higher circulating FGF21 levels are related to nutritional status and insulin resistance independent of PCOS. Increased FGF21 is associated with metabolic but not hormonal disturbances.

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“…Notably, the inverse relation between omentin levels on the one hand and 2-h glucose, 2-h insulin and ISI (composite), which represents an OGTT-derived measure of insulin sensitivity that is more closely related to clamp-measured insulin sensitivity than HOMA-IR (23), on the other hand remained significant after adjustment for BMI, but not after adjustment for lipids or adiponectin. Some (10,26), but not other (7,11,27,28), studies reported inverse associations between omentin and fasting glucose in univariate analyses. One study reported inverse associations with fasting glucose, 2-h glucose and HbA1c in univariate, but not in multivariate analyses (12).…”

Section: Omentin and Glucose Metabolismmentioning

confidence: 93%

“…One study reported inverse associations with fasting glucose, 2-h glucose and HbA1c in univariate, but not in multivariate analyses (12). Results were also conflicting for fasting insulin and HOMA-IR with several studies observing inverse associations for insulin (27) and HOMA-IR (8,10,11,12,14,27), whereas others reported no significant relationships for insulin (7,11,12) or HOMA-IR (7, 26). Overall, the comparison of study results is hampered by the differences in sample selection, sample size and statistical …”

Section: Omentin and Glucose Metabolismmentioning

confidence: 99%

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

Herder

Ouwens

Carstensen

et al. 2015

European Journal of Endocrinology

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Objective: Reduced circulating omentin levels have been reported in obesity and type 2 diabetes, but data were mostly derived from univariate analyses in small study samples. This study aimed to investigate the relationship between omentin, abnormal glucose tolerance and related metabolic factors in a large population-based cross-sectional study. Design and methods: Serum omentin was measured by ELISA in 1092 participants of the German KORA F4 survey (2006)(2007)(2008). Associations between omentin serum levels, glucose tolerance (assessed with an oral glucose tolerance test) and diabetesrelated factors were estimated using logistic and linear regression models respectively. Results: Serum levels of omentin were not related to categories of glucose tolerance. However, serum omentin was positively associated with whole-body insulin sensitivity index (ISI (composite)) and HDL cholesterol and showed inverse associations with 2-h post-load glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance, BMI and triglycerides (all P%0.03 after adjustment for age, sex and lifestyle factors). Further adjustment for BMI and/or serum lipids attenuated the associations with parameters of glucose metabolism, whereas adjustment for serum adiponectin virtually abolished all aforementioned associations. In contrast, adjustment for omentin had no effect on the positive association between adiponectin levels and ISI (composite). Conclusions: The data from this large population-based cohort show that circulating omentin levels are associated with insulin sensitivity. Our observations further suggest that omentin acts via upregulation of adiponectin, which in turn affects lipid metabolism and thereby also indirectly enhances insulin sensitivity, but mechanistic studies are required to corroborate this hypothesis.

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Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome

Cited by 39 publications

References 31 publications

Circulating anti‐Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome

Circulating anti‐Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome

Circulating FGF21 levels are related to nutritional status and metabolic but not hormonal disturbances in polycystic ovary syndrome

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

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