Plasma oxidative stress is induced by single‐sprint anaerobic exercise in young cigarette smokers

Taito, Shunsuke; Sekikawa, Kiyokazu; Oura, Keisuke; Kamikawa, Norimichi; Matsuki, Ryosuke; Kimura, Tatsuo; Takahashi, Makoto; Inamizu, Tsutomu; Hamada, Hironobu

doi:10.1111/cpf.12007

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…Exercise-induced oxidative stress is also increased by cigarette smoking. Indeed, multiple studies have found that plasma oxidative stress after strenuous exercise is higher in smokers than in nonsmokers11, 13 ) . However, these effects have not been examined following moderate-intensity exercise, which is optimal for promoting health, improvement of physical fitness, and rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

“…Smokers refrained from smoking cigarettes for 12 h before the study to avoid the acute effects of cigarette smoking on hydroperoxide concentrations in plasma and hydrogen peroxide (H 2 O 2 ) concentrations in exhaled breath condensate (EBC)3, 12, 13 ) .…”

Section: Methodsmentioning

confidence: 99%

“…Plasma hydroperoxide concentrations were determined with a Diacron derivatives of reactive oxygen metabolites (d-ROMs) test kit (Grosseto, Italy) using a spectrophotometer (Free Radical Elective Evaluator; Diacron)13 ) . H 2 O 2 concentrations were measured in EBC samples with a d-ROMs Exhalation Test Kit (Diacron) using a spectrophotometer12 ) .…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, cigarette smoking increases the levels of plasma and pulmonary oxidative stress in concert with exercise. Interestingly, strenuous exercise produces higher amounts of ROS generation in the plasma and lungs of cigarette smokers than in those of nonsmokers11,12,13 ) .…”

Section: Introductionmentioning

confidence: 99%

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Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise

et al. 2014

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[Purpose] Cigarette smoking increases oxidative stress, which is a risk factor for several diseases. Moreover, strenuous exercise has been shown to induce plasma and pulmonary oxidative stress in young cigarette smokers. However, no previous reports have demonstrated whether plasma and pulmonary oxidative stress occur after moderate-intensity exercise. Therefore, the aim of this study was to clarify whether moderate-intensity exercise induces pulmonary and plasma oxidative stress in smokers. [Subjects] Ten young male smokers and 10 young male nonsmokers participated in this study. [Methods] Plasma hydroperoxide concentrations were measured at baseline and then immediately and 15 min after moderate-intensity exercise. Hydrogen peroxide concentrations in exhaled breath condensate were measured at baseline and after exercise. [Results] No significant interactions were found between smokers and nonsmokers in terms of hydroperoxide or hydrogen peroxide concentrations following moderate-intensity exercise at any time point. [Conclusion] These findings suggested that moderate-intensity exercise did not induce plasma or pulmonary oxidative stress in young cigarette smokers.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise

et al. 2014

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“…Anaerobic exercise is followed by an increase in lipid peroxide concentration and the total antioxidative capacity of blood plasma, which indicates disruptions to the prooxidant antioxidant balance [ 19 ]. Even though research has observed the activation of the κB nuclear factor in the nuclei of peripheral blood mononuclear cells [ 20 ], enzymatic antioxidant defense has not yet been unambiguously shown to have a significant role in preventing the development of oxidative stress following anaerobic exercise.…”

Section: Introductionmentioning

confidence: 99%

Changes in Non-Enzymatic Antioxidants in the Blood Following Anaerobic Exercise in Men and Women

et al. 2015

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PurposeThe aim of this study was to compare changes in total oxidative status (TOS), total antioxidative capacity (TAC) and the concentration of VitA, VitE, VitC, uric acid (UA), reduced (GSH) and oxidized glutathione (GSSG) in blood within 24 hours following anaerobic exercise (AnEx) among men and women.Methods10 women and 10 men performed a 20-second bicycle sprint (AnEx). Concentrations of oxidative stress indicators were measured before AnEx and 3, 15 and 30 minutes and 1 hour afterwards. UA, GSH and GSSH were also measured 24 hours after AnEx. Lactate and H+ concentrations were measured before and 3 minutes after AnEx.ResultsThe increase in lactate and H+ concentrations following AnEx was similar in both sexes. Changes in the concentrations of all oxidative stress indicators were significant and did not differ between men and women. In both sexes, TOS, TAC, TOS/TAC and VitA and VitE concentrations were the highest 3 minutes, VitC concentration was the highest 30 minutes, and UA concentration was the highest 1 hour after AnEx. GSH concentration was significantly lower than the initial concentration from 15 minutes to 24 hour after AnEx. GSSG concentration was significantly higher, while the GSH/GSSG ratio was significantly lower than the initial values 1 hour and 24 hour after AnEx.ConclusionsWith similar changes in lactate and H+ concentrations, AnEx induces the same changes in TAC, TOS, TOS/TAC and non-enzymatic antioxidants of low molecular weight in men and women. Oxidative stress lasted at least 24 hours after AnEx.

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Plasma Oxidative State Induced by Exercise in Young Heat-Not-Burn Cigarette Users

Takagi,

Hamada,

Sekikawa

et al. 2024

Nicotine and Tobacco Research

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Introduction Oxidative state, a risk factor for several diseases, is increased by habitual conventional cigarette (CC) smoking. Reports have demonstrated that heat-not-burn cigarettes (HNBC), which have recently become popular among smokers, generate less oxidative state than CC in smokers with a long smoking history. However, no previous study has examined oxidative state in young HNBC users. Previously, we reported that exercise induces a greater oxidative state in young CC smokers than in never-smokers of similar age, but there was no difference in resting oxidative state. This study aimed to clarify the resting and exercise-induced oxidative states in young HNBC users, compared with those in never-smokers and CC users of similar age. Methods Healthy young never-smokers, HNBC users, and CC users were recruited, and they underwent the Wingate anaerobic test. Blood samples were collected before and after exercise, and the plasma hydroperoxide concentration, a marker of oxidative state, was measured. Results No significant differences in pre-exercise plasma hydroperoxide concentrations were detected among never-smokers, HNBC users, and CC users (n = 10 each). Plasma hydroperoxide concentration was significantly increased after exercise in all participants. The exercise induced a significant increase in plasma hydroperoxide concentration in HNBC users compared with that in never-smokers (P < .005), but it was significantly decreased compared with that in CC users (P < .01). Conclusions The use of HNBC increased exercise-induced plasma oxidative state compared with that in never-smokers, indicating that HNBC may lead to the risk of oxidative damage. Implications This study, for the first time, reports exercise-induced oxidative state in young heat-not-burn cigarette users compared with never-smokers and conventional cigarette users. The exercise-induced oxidative state in heat-not-burn cigarette users was higher than that in never-smokers and lower than that in conventional cigarette users. Our study suggests that the use of heat-not-burn cigarettes increases the risk of acute oxidative damage.

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Plasma oxidative stress is induced by single‐sprint anaerobic exercise in young cigarette smokers

Cited by 6 publications

References 21 publications

Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise

Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise

Changes in Non-Enzymatic Antioxidants in the Blood Following Anaerobic Exercise in Men and Women

Plasma Oxidative State Induced by Exercise in Young Heat-Not-Burn Cigarette Users

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