Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data

Kloudova-Spalenkova, Alzbeta; Ueng, Yune-Fang; Wei, Shouzou; Kopečková, Kateřina; Guengerich, F. Peter; Souček, Pavel

doi:10.1016/j.jsbmb.2019.105566

Cited by 28 publications

(17 citation statements)

References 27 publications

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“…In line with this notion, in gastric cancer models 25-HC promoted cell invasion associated with the upregulation of matrix metalloproteinases-expression in vitro and in vivo [104,108]. Higher serum levels of 25-HC associated with hormone receptor-positive metastatic disease have been reported [104], however, this phenomenon was not replicated by other authors in a larger population [103].…”

Section: The Broad Role Of 27-hydroxycholesterol (27-hc)mentioning

confidence: 91%

“…Evidence suggests the heterogeneity in 27-HC content in the cancer tissues, authors propose a possible association due to differential invasion of macrophages, fibroblast and/or adipocytes, capable of synthesizing oxysterols [102]. In a recent report, serum oxysterols were determined in 58 patients with primary breast carcinoma in different tumor stages before treatment, reporting lower 27-HC levels in small tumors, in contrast with higher tumor burden [103]. In a prospective study, evaluation of oxysterols-profile in 29 patients before and after treatment with Tamoxifen (Tam) and aromatase inhibitors (AI) showed increased concentrations of 27-HC under AI response and not significant changes in Tam-treatment [104].…”

Section: The Broad Role Of 27-hydroxycholesterol (27-hc)mentioning

confidence: 99%

“…In this sense, in a 58 patient study with primary breast carcinoma, the low levels of CT were related with early stages of the disease, and a positive association was reported as dependent on the patients age. Authors have proposed a correlation among higher CT levels and a shorter disease-free survival compared with patients with lower levels [103]. However, further exploration of the implications and the metabolic fate of CT during oncogenesis are necessary.…”

Section: Epoxide-cholesterol Pathwaymentioning

confidence: 99%

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Impact of cholesterol-pathways on breast cancer development, a metabolic landscape

González-Ortiz¹,

Galindo-Hernández²,

Hernández-Acevedo³

et al. 2021

J. Cancer

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ApoB-lipoproteins and their components modulate intracellular metabolism and have been associated with the development of neoplastic phenomena, such as proliferation, anchorage-independent growth, epithelial-mesenchymal transition, and cancer invasion. In cancer cells, the modulation of targets that regulate cholesterol metabolism, such as synthesis de novo, endocytosis, and oxidation, are contributing factors to cancer development. While mechanisms associated with sterol regulatory element-binding protein 2 (SREBP-2)/mevalonate, the low-density lipoprotein receptor (LDL-R) and liver X receptor (LXR) have been linked with tumor growth; metabolites derived from cholesterol-oxidation, such as oxysterols and epoxy-cholesterols, also have been described as tumor processes-inducers. From this notion, we perform an analysis of the role of lipoproteins, their association with intracellular cholesterol metabolism, and the impact of these conditions on breast cancer development, mechanisms that can be shared during atherogenesis promoted mainly by LDL. Pathways connecting plasma dyslipidemias in conjunction with the effect of cholesterol-derived metabolites on intracellular mechanisms and cellular plasticity phenomena could provide new approaches to elucidate the triggering factors of carcinogenesis, conditions that could be considered in the development of new therapeutic approaches.

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Section: The Broad Role Of 27-hydroxycholesterol (27-hc)mentioning

confidence: 91%

Section: The Broad Role Of 27-hydroxycholesterol (27-hc)mentioning

confidence: 99%

Section: Epoxide-cholesterol Pathwaymentioning

confidence: 99%

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Impact of cholesterol-pathways on breast cancer development, a metabolic landscape

González-Ortiz¹,

Galindo-Hernández²,

Hernández-Acevedo³

et al. 2021

J. Cancer

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“…In this study, levels of seven oxysterols were analysed in plasma from 58 patients diagnosed with ER-positive and HER2-negative breast carcinoma, and associations with clinico-pathological data were evaluated. In addition to the previously mentioned CT and survival association, 27-HC and 7α-HC were associated with tumour size, and the level of CT and 5β,6β-EC was associated with tumour stage (Kloudova-Spalenkova et al, 2020).…”

Section: Oxysterols As Biomarkersmentioning

confidence: 66%

“…Another potential cancer biomarker is CT since its plasma level was significantly associated with disease-free survival of luminal subtype breast carcinoma patients (Kloudova-Spalenkova et al, 2020), making it a candidate prognostic factor. In this study, levels of seven oxysterols were analysed in plasma from 58 patients diagnosed with ER-positive and HER2-negative breast carcinoma, and associations with clinico-pathological data were evaluated.…”

Section: Oxysterols As Biomarkersmentioning

confidence: 99%

Oxysterols in cancer management: From therapy to biomarkers

Kloudova-Spalenkova

Holý

Souček

2020

British J Pharmacology

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Oxysterols are oxidized derivatives of cholesterol, both endogenous and exogenous.They have been implicated in numerous pathologies, including cancer. In addition to their roles in carcinogenesis, proliferation, migration, apoptosis, and multiple signalling pathways, they have been shown to modulate cancer therapy. They are known to affect therapy of hormonally positive breast cancer through modulating oestrogen receptor activity. Oxysterols have also been shown in various in vitro models to influence efficacy of chemotherapeutics, such as doxorubicin, vincristine, cisplatin, 5-fluorouracil, and others. Their effects on the immune system should also be considered in immunotherapy. Selective anti-cancer cytotoxic properties of some oxysterols make them candidates for new therapeutic molecules. Finally, differences in oxysterol levels in blood of cancer patients in different stages or versus healthy controls, and in tumour versus non-tumour tissues, show potential of oxysterols as biomarkers for cancer management and patient stratification for optimization of therapy.

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Implication of Oxysterols and Phytosterols in Aging and Human Diseases

Vigne,

Pot

2023

Advances in Experimental Medicine and Biology

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Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data

Cited by 28 publications

References 27 publications

Impact of cholesterol-pathways on breast cancer development, a metabolic landscape

Impact of cholesterol-pathways on breast cancer development, a metabolic landscape

Oxysterols in cancer management: From therapy to biomarkers

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

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