Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study

Romano, Megan E.; Gallagher, Lisa G.; Price, George; Crawford, Kathryn A.; Criswell, Rachel; Baker, Emily; Botelho, Julianne Cook; Calafat, Antonia M.; Karagas, Margaret R.

doi:10.1016/j.ijheh.2024.114359

International Journal of Hygiene and Environmental Health

2024

DOI: 10.1016/j.ijheh.2024.114359

|View full text |Cite

Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study

Megan E. Romano,

Lisa G. Gallagher,

George Price

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Whole mount preparation and analysis of rabbit mammary gland

Rawtani,

Jackson,

Gao

et al. 2024

Reproductive Toxicology

View full text Add to dashboard Cite

Whole mount preparation and analysis of rabbit mammary gland

Rawtani,

Jackson,

Gao

et al. 2024

Reproductive Toxicology

View full text Add to dashboard Cite

Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort

Criswell,

Bauer,

Christensen

et al. 2024

Environmental Epidemiology

View full text Add to dashboard Cite

Background: Per- and polyfluoroalkyl substances (PFAS) are a class of persistent synthetic chemicals that are found in human milk and are associated with negative health effects. Research suggests that PFAS affect both lactation and the human metabolome. Methods: We measured perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the milk of 425 participants from the New Hampshire Birth Cohort Study using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A nontargeted metabolomics assay was performed using LC with high-resolution MS, and metabolites were identified based on in-house database matching. We observed six metabolic profiles among our milk samples using self-organizing maps, and multinomial logistic regression was used to identify sociodemographic and perinatal predictors of these profiles, including infant sex, parity, participant body mass index, participant age, education, race, smoking status, gestational weight gain, and infant age at time of milk collection. Results: Elevated PFOA was associated with profiles containing higher amounts of triglyceride fatty acids, glycerophospholipids and sphingolipids, and carnitine metabolites, as well as lower amounts of lactose and creatine phosphate. Lower concentrations of milk PFOS were associated with lower levels of fatty acids. Conclusion: Our findings suggest that elevated PFOA in human milk is related to metabolomic profiles consistent with enlarged milk fat globule membranes and altered fatty acid metabolism. Further, our study supports the theory that PFAS share mammary epithelial membrane transport mechanisms with fatty acids and associate with metabolic markers of reduced milk production.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study

Cited by 2 publications

References 38 publications

Whole mount preparation and analysis of rabbit mammary gland

Whole mount preparation and analysis of rabbit mammary gland

Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort

Contact Info

Product

Resources

About