2020
DOI: 10.1002/mnfr.201901055
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Plasma Phospholipids with Long‐Chain Polyunsaturated Fatty Acids and Dihydroceramides at the Crossroads of Iron Stores and Insulin Resistance

Abstract: Scope Iron plays an important role in the pathogenesis of insulin resistance (IR) and type 2 diabetes. Recent studies suggest a role of specific lipids in the induction of IR, but the potential relationships between iron and lipid metabolites in relation to IR have not been explored. Therefore, the aim of the study is to evaluate the association among iron, IR, and the lipidome. Methods and results The plasma lipidome, IR, parameters of iron metabolism, and several cytokines and adipokines in 65 overweight/obe… Show more

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Cited by 3 publications
(2 citation statements)
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“…In addition to insulin resistance and dyslipidaemia, ferritin levels and levels of iron stores in the liver have also been associated with the build-up of iron in adipose tissue, which leads to insulin resistance, impaired adiponectin secretion and altered endocrine function in mouse models and in patients 55,56,60 , as well as impaired regulation of amino acid and phospholipid metabolism in patients with fatty liver 61,62 . Indeed, ferroportin is also expressed in adipocytes, where it can be targeted by hepcidin to exert its endocrine function 55 .…”
Section: Role Of Excess Iron In Tissue Damage and Insulin Resistancementioning
confidence: 99%
“…In addition to insulin resistance and dyslipidaemia, ferritin levels and levels of iron stores in the liver have also been associated with the build-up of iron in adipose tissue, which leads to insulin resistance, impaired adiponectin secretion and altered endocrine function in mouse models and in patients 55,56,60 , as well as impaired regulation of amino acid and phospholipid metabolism in patients with fatty liver 61,62 . Indeed, ferroportin is also expressed in adipocytes, where it can be targeted by hepcidin to exert its endocrine function 55 .…”
Section: Role Of Excess Iron In Tissue Damage and Insulin Resistancementioning
confidence: 99%
“…On the other hand, PC(43:4), DG (36:6)(42:7)(44:9), PG(O 28:0)(O 30:1)(44:0), and PE(52:4) levels were downregulated. Circulating levels of PC, PE, DG, and TG have been positively correlated to insulin resistance in adults [46], so we posited that the downregulation of DG, PE, and PC in the PE cohort after early lifestyle intervention may have a positive impact on insulin resistance in adulthood. Given that circulating PCs are an essential source of triglycerides in steatosis [44], downregulation of PC triggered by early lifestyle intervention in the PE cohort may also have a positive impact on hepatic steatosis.…”
Section: Discussionmentioning
confidence: 97%