Plasma Progesterone in Normal Subjects and Patients with Benign Essential Hypertension on Normal, Low, and High Sodium Intake1

Sasaki, C.; Nowaczynski, W.; Küchel, Otto; Chavez, Carlos M.; Ledoux, F.; Gauthier, Sylvie F.; Genest, Jacques

doi:10.1210/jcem-34-4-650

Cited by 10 publications

(6 citation statements)

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“…In the present findings, some patients with EH had above the normal plasma progesterone levels as Sasaki et al (1972) had previously reported, although plasma progesterone levels in baseline samples and the responses to ACTH infusion were not significantly different between normal and hypertensive patients. ACTH was signiVcantly higher in patients with EH than in control subjects.…”

Section: Discussionsupporting

confidence: 70%

“…The data of baseline DOC levels in EH are in agreement with previous studies (Brown et al, 1972). In the study of the secretion rate of 18-OH DOC, a steroid thought to be derived from progesterone and DOC (Peron, 1962) the baseline levels in patients with EH were higher than those in control subjects as Nowaczynski et al (1972 a) had previously reported. However, the difference was not significant, probably because in this experiment, the secretion rates of 18-OH DOC in hypertensive patients showed a wide scatter of values.…”

Section: Discussionmentioning

confidence: 89%

“…This could be due, at least to some extent, to the lower plasma cortisol concentrations in EH than normal ones (Sasaki et al, 1972).…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, several reports from other laboratories (Melby et al, 1971;Melby et al, 1972;Nowaczynski et al, 1972 a) have shown that the secretion rates of 18-hydroxy-11-deoxycorticosterone (18 -OH DOC) and the urinary excretion of 18-hydroxy-tetrahydro-deoxycorticosterone were significantly higher in patients with EH and suppressed PRA. On the other hand, previous studies have indicated that many of these patients, especially those with low PRA, have signiwhile cortisol and corticosterone concentrations were below the normal mean (Mendelsohn et al, 1972;Nowaczynski et al, 1972b ;Sasaki et al, 1972 was found that the increased responses of plasma aldosterone to ACTH infusion were found in EH with normal PRA as well as low PRA, while the patients with low PRA showed, moreover, significantly higher responses of plasma DOC to ACTH infusion (Honda et al, in press). …”

Section: Synopsismentioning

confidence: 99%

“…Japon. June 1976 There have been numerons reports on various abnormalities in steroid metabolism in essential hypertension (EH) (Cooper et al, 1958;Genest et al, 1960;Vermeulen and Van der Straeten, 1963;Shao et al, 1970;Melby et al,1971;Brown et al, 1972;Melby et al, 1972;Mendelsohn et al, 1972;Nowaczynski et al, 1972 a and b;Sasaki et al, 1972;Sekihara et al, 1973;Grim et al, 1974;Nowaczynski et al, 1975). However, in many of these studies, steroids have not been investigated systematically and also, steroids other than aldosterone have not commanded much attention.…”

Section: Synopsismentioning

confidence: 99%

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Effects of ACTH on Plasma Levels of Adrenal Steroids in Essential Hypertension

Honda

1976

Endocrinol Japon

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SynopsisPlasma concentrations of progesterone (P), deoxycorticosterone (DOC), 17-hydroxyprogesterone (17-OH P), corticosterone (B), deoxycortisol (S), cortisol (F) and aldosterone (A) in 8 control subjects (mean age: 40.5 years) and 10 patients with essential hypertension (EH) (mean age: 48.5 years) were determined before, 4 and 8 hours after an infusion of ACTH at a rate of 25 units per 8 hours.Secretion rates (SR) of 18-hydroxy-11-deoxycorticosterone (18-OH DOC) were measured 24 hours before and again on the day of ACTH infusion.All subjects were studied on the fourth day of a diet containing 135 mEq of sodium and 90 mEq of potassium.There was no statistically significant difference between 8 control subjects and 10 patients with FH in the 7 plasma steroid levels and the SR of 18-OH DOC before ACTH infusion.The mean plasma presponse to ACTH was slightly lower in controls than in patients with EH, while that of 17-OH p(in male subjects) was slightly higher. The mean plasma B response was significantly lower atter 4 nours or At., in infusion (p<0.01), while that of DOC was significantly higher after 8 hours of ACTH infusion (p<0.05) in patients with EH. The mean plasma S rose significantly more in patients with EH (p<0.025) at 4 and 8 hours after ACTH infusion.The mean plasma F response to ACTH infusion was slightly lower in patients with EH than in controls.The mean response of 18-OH DOC SR to ACTH infusion was slightly higher in patients with EH than in controls.The mean plasma A response was significantly higher in patients with EH than in controls 4 (p<0.05) and 8 hours (p<0.001) after an ACTH infusion.These results could be explained in part by abnormalities in the 17-and 11-hydroxylase systems, and that the abnormality in 11-hydroxylation was more pronounced than that in the 17-position.Furthermore, we suspect that the sensitivity of adrenal aldosterone to ACTH might be increased or another accelerated pathway to aldosterone biosynthesis might exist in patients with EH.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 89%

“…This could be due, at least to some extent, to the lower plasma cortisol concentrations in EH than normal ones (Sasaki et al, 1972).…”

Section: Discussionmentioning

confidence: 97%