Plasma protein adsorption and thrombus formation on surface functionalized polypyrrole with and without electrical stimulation

Li, Yali; Neoh, K. G.; Kang, En‐Tang

doi:10.1016/j.jcis.2004.02.060

Cited by 65 publications

(50 citation statements)

References 54 publications

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“…Their results showed that cell attachment on a hyaluronic acid functionalized PPy film surface was significantly enhanced in the presence of nerve growth factor. Li et al (2004) immobilized heparin on the surface of PPy film covalently via poly(ethylene glycol) methacrylate graft copolymerization. The immobilization of heparin on the PPy surface had a significant effect on the selective adsorption of plasma proteins, albumin and fibrinogen and consequently the formation of thrombus.…”

Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

616

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Modification Of Conductive Polymers With Bioactive Moleculesmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

616

389

View full text Add to dashboard Cite

show abstract

“…Of particular interest is potential-assisted control of protein adsorption, which has been shown to either enhance or resist protein adsorption 58,59 . Potential assisted adsorption is generally described by electrostatic attractive forces of negatively charged proteins (typically isoelectric point < neutral pH) to a positively charged electrode.…”

Section: Protein Interactionsmentioning

confidence: 99%

Surface and Biomolecular Forces of Conducting Polymers

Higgins

Wallace

2013

Polymer Reviews

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In this review, we provide insight into the surface forces of conducting polymers, a class of intelligent materials that offer unique strategies for controlling biomolecular interactions in wide-ranging biomedical applications. Critical to the success of these applications is that the polymer interface is exposed to biological fluids whose interactions are controlled through the polymer surface chemistry and electrochemical switching of the surface properties. There is, however, little known about the intermolecular and surface forces that govern these interactions. Therefore, the purpose of this review is to more closely examine the forces that mediate interactions with biological entities, including forces such as van der Waals, electrostatic, hydrophobic, and hydrogen bonding. We introduce relevant surface properties such as surface energy and surface potential, and demonstrate how they manifest as forces. In particular, we highlight the emerging use of Atomic Force Microscopy for directly measuring these forces at the single molecule level; a unique capability that is enabling deconvolution of complex biomolecular interactions with conducting polymers. Finally, we provide an overview of biomolecular interactions, namely model proteins and DNA, and conclude by discussing a growing area of interest; the spatio-temporal and reversible control of biomolecular forces via electrical stimulation. AbstractIn this review, we provide insight into the surface forces of conducting polymers, a class of

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“…Conducting-polymer hollow spheres can be further created by removing the PS core ( Figure 11.2). This colloidal approach was extensively investigated not only because it allows improvement of the processability of conductingpolymer materials, but also because of the attractive properties of these materials, for example, well-defined colloidal dimensions or morphologies [23], intense coloration, biocompatibility [28], high surface area, efficient radiation absorption, wide spectrum of surface functionalization, good film-forming properties, and so forth [26,[29][30][31][32]. There has been a massive amount of work on the synthesis, characterization, and use of latex particles coated with conducting-polymer shells in solution.…”

Section: Hollow Spheresmentioning

confidence: 99%