Plasma proteins and persistent postsurgical pelvic pain among adolescents and young adults with endometriosis

Sasamoto, Naoko; Ngo, Long; Vitonis, Allison F.; Dillon, Simon T.; Prasad, Pooja; Laufer, Marc R.; As-Sanie, Sawsan; Schrepf, Andrew; Missmer, Stacey A.; Libermann, Towia A.; Terry, Kathryn L.

doi:10.1016/j.ajog.2024.03.005

Cited by 2 publications

(1 citation statement)

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“…In addition to this, there are studies that have reported that about 30% of endometriosis patients suffer from chronic pelvic pain after the excision of the endometriotic lesions in the pelvic area [ 174 , 175 ]. Recent studies focused on adolescents and young adults with endometriosis have identified plasma proteins and biological pathways associated with persistent pelvic pain post-surgical treatment of endometriosis [ 176 ]. These new studies could provide new opportunities for improved personalized treatment and faster symptom improvement to manage the pain in young women with endometriosis.…”

Section: Management and Treatment In Current Clinical Practicementioning

confidence: 99%

The Known, the Unknown and the Future of the Pathophysiology of Endometriosis

Ochoa Bernal,

Fazleabas

2024

IJMS

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Endometriosis is one of the most common causes of chronic pelvic pain and infertility, affecting 10% of women of reproductive age. A delay of up to 9 years is estimated between the onset of symptoms and the diagnosis of endometriosis. Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites; however, advances in research on endometriosis have some authors believing that endometriosis should be re-defined as “a fibrotic condition in which endometrial stroma and epithelium can be identified”. There are several theories on the etiology of the disease, but the origin of endometriosis remains unclear. This review addresses the role of microRNAs (miRNAs), which are naturally occurring post-transcriptional regulatory molecules, in endometriotic lesion development, the inflammatory environment within the peritoneal cavity, including the role that cytokines play during the development of the disease, and how animal models have helped in our understanding of the pathology of this enigmatic disease.

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Section: Management and Treatment In Current Clinical Practicementioning

confidence: 99%