Plasma renin activity during supine exercise in offspring of hypertensive parents

Fasola, Alfred F.; Martz, B. L.; Helmer, O. M.

doi:10.1152/jappl.1968.25.4.410

Cited by 58 publications

(26 citation statements)

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“…The relationship of angiotensinogen to blood pressure was first recognized 25 yr ago when Fasola et al (2) found that the serum angiotensinogen concentration was higher in a group of hypertensive subjects and their offspring than in a group of normotensive subjects. Walker et al (3) subsequently showed in a population that included hypertensives that the diastolic blood pressure was more highly related to the angiotensinogen level (r = 0.39) than any other parameter of blood pressure regulation analyzed.…”

Section: Discussionmentioning

confidence: 99%

“…All promotes sodium retention and increases vascular resistance and is thus important for blood pressure regulation. The concentration of angiotensinogen is a rate-limiting factor in the generation of All ( 1), and its circulat-ing level has been positively related to blood pressure (2,3). The angiotensinogen gene (AGT) was linked recently to human hypertension in a study from France and the United States (4).…”

Section: Introductionmentioning

confidence: 99%

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The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

Bloem¹,

Manatunga²,

Tewksbury³

et al. 1995

J. Clin. Invest.

226

129

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The T235 allele of the angiotensinogen gene (AGT) has been associated with hypertension. Blood pressure increases faster over time in black children than in white children, and in adults hypertension is more prevalent in blacks. We sought evidence for a role for angiotensinogen to contribute to racial differences in blood pressure in a study of 148 white and 62 black normotensive children (mean age, 14.8 yr). The frequency of the T235 allele was 0.81 in blacks and 0.42 in whites (X2 = 77.3, P = 0.0001). The mean angiotensinogen level was 19% higher in blacks than in whites (P = 0.0001 for males, P = 0.004 for females). Genotype was positively related to serum angiotensinogen in white children (P = 0.0001 for males, P = 0.004 for females), but a similar relationship was absent in blacks where the frequency of M235 may have been too low to discern an association. Longitudinal blood pressure (measured twice yearly) adjusted for body mass index showed a marginally significant relationship to the angiotensinogen level (P = 0.07). An independent relationship of serum angiotensinogen with body mass index (P = 0.0001) and race (P = 0.0003) was also observed. In summary, T235 was more frequent, and the level of angiotensinogen was higher in blacks than in whites. Such a racial difference in the renin-angiotensin system may contribute to the disparity in blood pressure levels of white and black young people. (J. Clin. Invest. 1995. 95:948-953.)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

Bloem¹,

Manatunga²,

Tewksbury³

et al. 1995

J. Clin. Invest.

226

129

View full text Add to dashboard Cite

show abstract

“…4,[17][18][19][20][21][22][23][24][25][26][27][28][29] Contradictions in these findings were attributed to the ethnicity of the populations studied. Plasma AGT concentration was reported to differ between hypertensives and normotensives, 30,31 and a positive relation between plasma AGT and blood pressure was supported by physiological 32 and pharmacological 33,34 studies. In contrast, a community study from Jamaica reported a weak correlation between the circulating angiotensin levels and blood pressure.…”

Section: Introductionmentioning

confidence: 92%

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Charita

Gunda

Sushma

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Introduction:The risk conferred by the variants and haplotypes of single nucleotide polymorphisms (SNPs) at human angiotensinogen (AGT) gene to essential hypertension (EHT) have been described in several populations with variations in the results attributed to their ethnicity. We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT. Method: Two-hundred and forty-nine hypertensives and 248 controls were genotyped for the selected markers. Results: Study of demographic parameters revealed significant association of obesity, positive family history and nonvegetarian diet habit, suggesting elevated risk of the condition when associated with these parameters. Significantly high risk for males with AA genotype of -217G>A polymorphism was observed for developing EHT (p = .07). Males with -217A (p = .01) showed a two-fold higher risk for EHT. Markers -217G>A and -6G>A were in strong linkage disequilibrium in patients as compared to controls. Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT. Conclusion: Our findings suggest that -217A variant is significantly associated with the risk for EHT in males. Further studies on the functional role of the marker -217 are recommended for understanding the cause of association with EHT. KeywordsEssential hypertension (EHT), angiotensinogen (AGT), linkage disequilibrium (LD), multifactor dimensionality reduction (MDR), single nucleotide polymorphism (SNP), haplotype association, epistatic interaction, statistical package for social sciences (SPSS)

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“…25 Several reports show that the AGT genotype has a moderate but significant effect on plasma AGT concentration. Plasma AGT is elevated Ϸ20% in men and women carrying the 235T allele.…”

Section: Plasma Agtmentioning

confidence: 99%

Seven Lessons From Two Candidate Genes in Human Essential Hypertension

et al. 1999

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Abstract-The candidate gene approach to understanding the genetics of human essential hypertension is discussed by analyzing the contribution of 2 genes, angiotensinogen (AGT) and epithelial amiloride-sensitive sodium channel (ENaC). From a large series of studies conducted in humans and animals, it appears that the AGT gene plays a significant but modest role in human blood pressure variance. Mutations of the ␤-and ␥-ENaC subunits are responsible for Liddle's syndrome, but the implication of the 3 ENaC subunits in essential hypertension is still questionable. Several lessons can be learned from these studies and applied to other candidate genes in essential hypertension: (1) Many linkage or association studies have a limited statistical power; (2) The genetic findings may vary greatly according to the populations studied; (3) There is a need for better phenotyping of the hypertensive population; (4) The causal relationship between molecular variants and hypertension is and will be difficult to establish firmly; (5) The contribution of genetic studied in rodents to the molecular genetics of human hypertension must be re-examined; (6) Most molecular variants lead to a low attributable risk in the population or a low individual effect at the individual level; and (7)

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Plasma renin activity during supine exercise in offspring of hypertensive parents

Cited by 58 publications

References 0 publications

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children.

Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Seven Lessons From Two Candidate Genes in Human Essential Hypertension

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