Plasma Renin Activity in Hyper- and Hypothyroidism: Effect of Adrenergic Blocking Agents

Hauger-Klevene, Julia H.; Brown, Harold; Zavaleta, J. Abad

doi:10.1210/jcem-34-4-625

Cited by 51 publications

(48 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRA levels in hyperthyroid patients were significantly greater than those in normal subjects, which in turn were greater than those in hypothyroid patients. The adminis tration of propranolol or dibenzylene caused PRA levels to decrease in hyperthyroid patients (5). Thyroidectomy decreases PRA and PRC in rats (4,10,11 ).…”

Section: Discussionmentioning

confidence: 97%

“…Isoproterenol in creases PRA and PRC in control animals, but has no effect on thyroidectomized rats (11). These changes are related to either sympa thetic or beta-adrenergic activity (5,11). How ever, Dzau and Herrmann (2) reported that hyperthyroid rats show increased PAC with out significant changes in PAR or PRC, and hypothyroid rats show a decreased PAC as sociated with unchanged PRA and PRC.…”

Section: Discussionmentioning

confidence: 98%

“…Thyroid hormone affects the production and secretion of angiotensinogen from liver slices (2, 3) and perfused liver (4). Plasma renin activity (PRA) increases during hyperthyroidism and decreases during hypothyroidism in both patients and rats (3,5). Hence, thyroid hor mone may affect both the production and release of renin and angiotensinogen.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

et al. 1990

View full text Add to dashboard Cite

Abstract-We studied the expression of angiotensinogen and renin genes in rats treated with 3,3',5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight. Liver angiotensinogen mRNA increased by 2 to 3 times 8 to 12 hours after T3-treatment. This increase was dose-related. Plasma angiotensinogen concen tration (PAC) increased 12 hours after T3-treatment. Brain and renal angiotensi nogen mRNA levels and the renal renin mRNA level remained the same throughout the experimental periods. These results suggest that the thyroid hormone initially increases angiotensinogen mRNA and leads to an increase in the production of angiotensinogen in the liver followed by an elevation of PAC.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

et al. 1990

View full text Add to dashboard Cite

show abstract

“…Renin is an aspartyl protease that cleaves AI decapeptide from the angiotensinogen molecule, and numerous in vivo studies have demonstrated the influence of thyroid hormones on circulating renin. Experimental hyperthyroidism produces an increase in plasma renin activity (PRA) and plasma renin concentration (PRC), while the induction of hypothyroidism in adult rats reduces PRA and PRC (Hauger-Klevene & Levin 1976, Jiménez et al 1982. However, different results were obtained when hypothyroidism was induced by surgical thyroidectomy in rats in the first day of life, when an increase in renal renin content (Bouhnik et al 1981) and PRC (Jiménez et al 1984) was observed, suggesting the operation of distinct mechanisms according to the age at which the thyroid hormone deficit is produced.…”

Section: Reninmentioning

confidence: 99%

“…These actions of thyroid hormones on renin secretion and renin mRNA are direct and not mediated by changes in sympathetic nervous system activity (Kobori et al 1997a,b). However, the above studies do not rule out the possibility that RAS activity modifications in thyroid Hauger-Klevene & Levin 1976, Jiménez et al 1982, Santos & Ferreira 2007 [ (Jiménez et al 1984);Y (Hauger-Klevene & Levin 1976, Jiménez et al 1982) Angiotensin-converting enzyme [ (Phillips et al 1993) Y , Jiménez et al 1990) Angiotensin II [ (Marchant et al 1993, Garcia del Río et al 1997, Kobori et al 1997a Y (Marchant et al 1993, Kobori et al 1997a New RAS components --Heart Renin Kobori et al 1997a,b, 1999 Marchant et al 1993 [ (Marchant et al 1993) Kidney Renin [ (Bouhnik et al 1981, Kobori et al 1997a,b, Klein & Ojamaa 2001)…”

Section: Reninmentioning

confidence: 99%

The renin–angiotensin system in thyroid disorders and its role in cardiovascular and renal manifestations

Vargas¹,

Rodríguez-Gómez²,

Vargas-Tendero³

et al. 2011

Journal of Endocrinology

View full text Add to dashboard Cite

Thyroid disorders are among the most common endocrine diseases and affect virtually all physiological systems, with an especially marked impact on cardiovascular and renal systems. This review summarizes the effects of thyroid hormones on the renin-angiotensin system (RAS) and the participation of the RAS in the cardiovascular and renal manifestations of thyroid disorders. Thyroid hormones are important regulators of cardiac and renal mass, vascular function, renal sodium handling, and consequently blood pressure (BP). The RAS acts globally to control cardiovascular and renal functions, while RAS components act systemically and locally in individual organs. Various authors have implicated the systemic and local RAS in the mediation of functional and structural changes in cardiovascular and renal tissues due to abnormal thyroid hormone levels. This review analyzes the influence of thyroid hormones on RAS components and discusses the role of the RAS in BP, cardiac mass, vascular function, and renal abnormalities in thyroid disorders.

show abstract

Serum angiotensin-converting enzyme. Alterations in hyperthyroidism, hypothyroidism, and subacute thyroiditis

Smallridge

Rogers

Verma

1983

JAMA: The Journal of the American Medical Association

View full text Add to dashboard Cite

Angiotensin-converting enzyme (ACE) activity was measured in the serum samples of 247 patients with varying thyroid states. In 60 hyperthyroid patients, the mean (+/- SD) ACE level of 29.5 +/- 9.7 units/mL was higher than in all other groups. The serum ACE level was 17.0 +/- 5.1 units/mL in 129 euthyroid subjects and differed from the level of 13.9 +/- 5.1 units/mL observed in 34 hypothyroid patients. Twenty-four patients receiving exogenous thyroid hormone had elevated serum thyroxine values. Their mean serum triiodothyronine level was in the normal range, and the mean ACE level did not differ from the euthyroid mean. The mean serum ACE level fell from 30.8 to 17.4 units/mL in 35 hyperthyroid patients studied before and after therapy. In 12 hypothyroid subjects, the mean serum ACE level rose from 11.6 to 15.8 units/mL after thyroid hormone replacement. In eight of ten patients with transient hyperthyroidism (subacute thyroiditis or painless thyrotoxic thyroiditis), their highest ACE levels were observed in the hyperthyroid or transition phase and fell progressively with the lowest values being recorded during the hypothyroid or early recovery phases. Thus, ACE activity may respond to thyroid hormone, and interpretation of serum ACE levels may require knowledge of the patient's thyroid status. Serum ACE may be useful as a probe for exploring peripheral thyroid hormone action.

show abstract

Plasma Renin Activity in Hyper- and Hypothyroidism: Effect of Adrenergic Blocking Agents

Cited by 51 publications

References 0 publications

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

The renin–angiotensin system in thyroid disorders and its role in cardiovascular and renal manifestations

Serum angiotensin-converting enzyme. Alterations in hyperthyroidism, hypothyroidism, and subacute thyroiditis

Contact Info

Product

Resources

About