Plasma Renin and Cardiovascular Risk: What Is the Evidence for an Association?

Volpe, Massimo; Unger, Thomas

doi:10.1159/000348365

Cited by 11 publications

(9 citation statements)

References 131 publications

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“…Because modest changes in plasma renin are also observed in many patients with hypertension, 37 our observations imply that limited changes in Cx40 expression may have a relevant pathogenic role in some forms of clinical hypertension. 38,39 Genetic analyses have to date provided variable support for this hypothesis, 40 presumably because small changes of Cx40 expression, which are likely to be missed by present large-scale genetic analyses, may suffice to control human blood pressure, like we now report in the kidney of hRen-Cx40 mice.…”

Section: Discussionmentioning

confidence: 64%

Restoration of Connexin 40 (Cx40) in Renin-Producing Cells Reduces the Hypertension of Cx40 Null Mice

et al. 2014

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Abstract-Connexin 40 (Cx40) is expressed by the renin-producing cells (RSCs) of the kidneys and the endothelial cells of blood vessels. Cx40 null mice (Cx40 −/− ) feature a much increased renin synthesis and secretion, which results in chronic hypertension, and also display an altered endothelium-dependent relaxation of the aorta because of reduced eNOS levels and nitric oxide production. To discriminate the effect of Cx40 in renin secretion and vascular signaling, we targeted Cx40 to either the RSCs or the endothelial cells of Cx40 null mice. When compared with Cx40 −/− controls, the animals expressing Cx40 in RSCs were less hypertensive and featured reduced renin levels, still numerous RSCs outside the wall of the afferent arterioles. In contrast, mice expressing Cx40 in the endothelial cells were as hypertensive as Cx40 −/− mice, in spite of control levels of Cx37 and eNOS. Our data show that blood pressure is improved by restoration of Cx40 expression in RSCs but not in endothelial cells, stressing the prominent role of renin in the mouse hypertension linked to

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Section: Discussionmentioning

confidence: 64%

Restoration of Connexin 40 (Cx40) in Renin-Producing Cells Reduces the Hypertension of Cx40 Null Mice

et al. 2014

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“…It is well established that RAAS activity is affected by postural changes. 16 Secretion of plasma renin and aldosterone increases after standing, with subsequent normalization after the supine position is assumed. 16 However, in a large proportion of hypertensive patients, the physiologic suppression of renin and aldosterone may not occur.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Regulation of Renin Angiotensin Aldosterone System Is Associated With Right Ventricular Dysfunction in Hypertension

Gregori

Giammarioli

Befani

et al. 2014

Canadian Journal of Cardiology

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“…The renin activity may be a marker of CVD risk in hypertensive patients [42]. ACE can generate the vasoactive peptide Ang II by cleaving 2 amino acids from the C-terminus of the inactive precursor Ang I [43].…”

Section: Discussionmentioning

confidence: 99%

Chinese Traditional Fermented Soy Sauce Exerts Protective Effects against High-Fat and High-Salt Diet-Induced Hypertension in Sprague-Dawley Rats by Improving Adipogenesis and Renin-Angiotensin-Aldosterone System Activity

et al. 2021

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Although high-fat and high-salt diets are considered risk factors for hypertension, the intake of salty soybean-based fermented foods has beneficial effects. This study explored the potential of Chinese traditional fermented soy sauce (CTFSS) in preventing hypertension by analyzing its effects on adipogenesis and the renin-angiotensin-aldosterone system (RAAS). Male Sprague-Dawley (SD) rats were divided into four groups (n = 6): normal diet (ND), high-fat diet (HD), high-fat diet with saline (HDS, NaCl-8%), and high-fat diet with Chinese traditional soy sauce (HDCTS, NaCl-8%). Each group is administrated 12 weeks by oral gavage as 10 mL/kg dose, respectively. CTFSS supplementation resulted in significantly lower body weight, epididymal fat weight, and systolic blood pressure. Additionally, it decreased the serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), renin, angiotensin II (Ang II), angiotensin-converting enzyme (ACE), and aldosterone levels. It also increased the urinary volume and improved sodium and potassium ion balance. The gene levels showed significant enhancements in the mRNA levels of renin-angiotensin-aldosterone system-related and adipogenesis-related genes. In addition, CTFSS may prevent hypertension-associated kidney injury. Therefore, this study demonstrates that CTFSS has no harmful effects on hypertension. In contrast, the beneficial effects of CTFSS intake in ameliorating hypertension were shown.

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Plasma Renin and Cardiovascular Risk: What Is the Evidence for an Association?

Cited by 11 publications

References 131 publications

Restoration of Connexin 40 (Cx40) in Renin-Producing Cells Reduces the Hypertension of Cx40 Null Mice

Restoration of Connexin 40 (Cx40) in Renin-Producing Cells Reduces the Hypertension of Cx40 Null Mice

Abnormal Regulation of Renin Angiotensin Aldosterone System Is Associated With Right Ventricular Dysfunction in Hypertension

Chinese Traditional Fermented Soy Sauce Exerts Protective Effects against High-Fat and High-Salt Diet-Induced Hypertension in Sprague-Dawley Rats by Improving Adipogenesis and Renin-Angiotensin-Aldosterone System Activity

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